The Influence of Preoperative Cardiopulmonary Capacity on the Perioperative Lactate Level

The Influence of Preoperative Cardiopulmonary Capacity Mesured in MET's (Metabolic Equivalents) on the Perioperative Lactate Level

The aim of this study is to identify if there exists a correlation between the preoperative cardiopulmonary capacity - measured in MET's - and the perioperative lactate serum level.

Study Overview

• Status: Completed
• Conditions: Sensitivity Training Groups; Complication, Cardio-respiratory

Detailed Description

The determination of the cardiopulmonary (c/p) capacity is very important for the evaluation of every patient undergoing surgery. The ability to climb at least two flight of stairs is seen to be an acceptable c/p capacity for surgery. There are several ways to evaluate the fitness of patients. A common method to estimate the cardiopulmonary capacity is defining patients through the MET's (metabolic equivalents) scale. MET's can be defined relatively easy through a simple questionnaire. Patients with a reduced c/p capacity have less than 4 MET's, patients with a relatively good c/p capacity have 4-10 MET's and patients with a excellent c/p capacity have more than 10 MET's.

The lactate level in blood serum is a common parameter to asses anaerobic metabolism in patients. A high lactate level correlates with higher mortality rates and outcome.

To yet it is not clear if there exists a correlation between the preoperative cardiopulmonary capacity measured in MET's and the perioperative lactate level. We hypothysed that patients with a reduced cardiopulmonary capacity are associated with higher perioperative lactate levels, as these group of patients compensate the stressors operation/anesthesia less than patients with a good c/p capacity.

• Study Type: Observational
• Enrollment (Actual): 1502

Contacts and Locations

Study Locations

• Germany
  • NRW
    • Wuppertal, NRW, Germany, 42283
      • Helios Klinikum Wuppertal

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

All patients undergoing elective/urgent or emergency surgery

Description

Inclusion Criteria:

• Age > 18 years

Exclusion Criteria:

• Cardiac surgery

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
lactate - venous blood gas analysis	mmol/l	venous lactate will be measured at anaesthesia induction and anesthesia termination - the average time frame is 2 hours

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
icu in hospital mortality		icu patients will be followed over their hospital stay over a maximum period of 6 months
hemoglobin - venous blood gas analysis	g/dl	hemoglobin will be measured at anaesthesia induction and anesthesia termination - the average time frame is 2 hours
icu ventilation time	hours/days	icu patients will be followed over their hospital stay over a maximum period of 6 months

Collaborators and Investigators

• Sponsor: University of Witten/Herdecke
• Investigators: Study Chair: Gerhard Schneider, Prof., Dept. Anaesthesiology

Study record dates

Study Major Dates

• Study Start: March 1, 2013
• Primary Completion (Actual): April 1, 2013
• Study Completion (Actual): August 1, 2013

Study Registration Dates

• First Submitted: February 8, 2013
• First Submitted That Met QC Criteria: March 26, 2013
• First Posted (Estimate): March 27, 2013

Study Record Updates

• Last Update Posted (Estimate): September 17, 2013
• Last Update Submitted That Met QC Criteria: September 15, 2013
• Last Verified: September 1, 2013

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Immune System Diseases; Hypersensitivity
• Other Study ID Numbers: Lactate1