- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01833429
Autonomic Dysfunction in Resistant Hypertension (RH)
Circadian Autonomic Disturbances in Resistant Hypertension With and Without White-coat Phenomenon
Study Overview
Status
Detailed Description
All patients were submitted to office blood pressure measurement, Ambulatory blood pressure monitoring and 24-hour Holter monitoring.
Baseline blood samples for the measurement of glycemia (mg/dL), total cholesterol (mg/dL), LDL cholesterol (mg/dL), triglycerides (mg/dL), creatinine (mg/dL), serum uric acid, serum sodium, serum potassium, plasma aldosterone concentration (PAC) and plasma renin activity (PRA) were collected at 08:00 after overnight fasting.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
-
-
Sao Paulo
-
Campinas, Sao Paulo, Brazil, 13083-888
- Cardiovascular Pharmacology Laboratory
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- resistant hypertensive patients
Exclusion Criteria:
- White-coat hypertension
- obstructive sleep apnea
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
---|
Resistant Hypertension
The current definition of resistant hypertension (RH) includes both patients whose blood pressure (BP) is uncontrolled on three or more medications and those whose BP is controlled when using four or more antihypertensive medications
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
evaluation of the autonomic function in resistant hypertensive patients
Time Frame: 10 months
|
The autonomic nervous system can be assessed by the heart rate variability. Variations in heart rate variability are normally observed in association with diurnal rhythms and blood pressure changes. The heart rate variability parameters are different in many studies, although the consensus is that lower values of the indices of vagal as well as high indices of sympathetic functions are associated prospectively with death and disability. In humans, the disturbances of the circadian rhythms of heart rate variability and blood pressure have been intensively studied, mainly due to the increased cardiovascular death reported during the morning hours |
10 months
|
Collaborators and Investigators
Sponsor
Publications and helpful links
General Publications
- Calhoun DA, Jones D, Textor S, Goff DC, Murphy TP, Toto RD, White A, Cushman WC, White W, Sica D, Ferdinand K, Giles TD, Falkner B, Carey RM; American Heart Association Professional Education Committee. Resistant hypertension: diagnosis, evaluation, and treatment: a scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research. Circulation. 2008 Jun 24;117(25):e510-26. doi: 10.1161/CIRCULATIONAHA.108.189141.
- Muxfeldt ES, Fiszman R, de Souza F, Viegas B, Oliveira FC, Salles GF. Appropriate time interval to repeat ambulatory blood pressure monitoring in patients with white-coat resistant hypertension. Hypertension. 2012 Feb;59(2):384-9. doi: 10.1161/HYPERTENSIONAHA.111.185405. Epub 2012 Jan 3.
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 907/2011
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Hypertension, Resistant to Conventional Therapy
-
University of FloridaNational Heart, Lung, and Blood Institute (NHLBI); Emory UniversityNot yet recruitingHypertension, Resistant to Conventional TherapyUnited States
-
Memorial Health University Medical CenterUnknownHypertension, Resistant to Conventional TherapyUnited States
-
University of CambridgeBritish Heart FoundationUnknownHypertension, Resistant to Conventional TherapyUnited Kingdom
-
Mayo ClinicWithdrawnHypertension, Resistant to Conventional TherapyUnited States
-
Tomsk National Research Medical Center of the Russian...Completed
-
University of ZurichTerminatedHypertension, Resistant to Conventional TherapySwitzerland
-
Hannover Medical SchoolMayo Clinic; Charite University, Berlin, Germany; University of Bristol; Vanderbilt...CompletedHypertension, Resistant to Conventional TherapyGermany
-
Universidade Federal de GoiasUnknownHypertension, Resistant to Conventional TherapyBrazil
-
Chinese Academy of Medical Sciences, Fuwai HospitalHuazhong University of Science and Technology; Shanghai Jiao Tong University...UnknownThe Diagnosis and Treatment of Resistant Hypertension, the Prevalence and the Prognosis (doublepres)Hypertension, Resistant to Conventional TherapyChina
-
Oslo University HospitalUnknownHypertension, Resistant to Conventional TherapyNorway