- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01870453
Differential Effects of Various Anesthetic Agents on Cognitive Function in Patients With Alzheimer's Disease
August 14, 2018 updated by: Zhongcong Xie, Massachusetts General Hospital
The objective of the study is to determine the effects of different anesthetic agents on cognitive function in patients with Alzheimer's disease (AD).
The investigators will test the hypothesis that anesthesia with desflurane or propofol, compared to isoflurane or sevoflurane, will have less of an effect on post-operative cognitive dysfunction in patients with AD.
Study Overview
Status
Withdrawn
Conditions
Detailed Description
Patients with mild-to-moderate Alzheimer's disease who are scheduled to have elective noncardiac, nonneurologic, nonvascular surgery will be recruited at the Massachusetts General Hospital (MGH).
The study will first be introduced to patients at their preoperative surgical clinic appointment by his/her surgeon.
If patients are interested in participating, they will notify their surgeons, and subsequent recruitment will take place at the MGH Pre-Admission Testing Area (PATA), a clinic for preoperative evaluation and medical optimization.
Patient contact and recruitment, however, will only proceed with permission from (1) the patient him/herself and (2) the patient's surgeon.
Per the Partners Human Research Committees-approved criteria, if patients do not have capacity for clinical-decision making but express a willingness to participate in the study, a surrogate (i.e.
healthcare proxy and/or family member) co-signature will be required on the consent form.
On the day of the subject's surgery, the anesthesia team will be allowed to choose one of four anesthetic options (i.e.
propofol anesthesia, isoflurane anesthesia, sevoflurane anesthesia, or desflurane anesthesia) based on clinical preference and appropriateness.
The research team will be blinded to the anesthetic to which subjects are assigned.
Finally, patients will be followed for one year post-operatively with a battery of cognitive tests to determine differences in cognitive trajectory.
Study Type
Observational
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Massachusetts
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Boston, Massachusetts, United States, 02114
- Massachusetts General Hospital
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
100 study participants with mild-to-moderate AD who are scheduled to have elective noncardiac, nonneurologic, nonvascular surgery will be recruited at MGH. Surgeons will first introduce the study to patients at their preoperative surgical clinic visit.
If a patient expresses interest in the study, and with permission of the surgeon, the patient will then be contacted by study staff at his/her PATA preoperative evaluation and medical optimization clinic visit.
Recruitment, screening, and enrollment will then occur at the patient's PATA clinic visit.
Description
Inclusion Criteria:
- Patients diagnosed with Alzheimer's disease (AD) per Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria.
- Patient recruitment permission granted by his/her surgeon
- Requires general anesthesia for elective noncardiac, nonneurologic, nonvascular surgery.
Exclusion Criteria:
- History of neurologic or psychiatric disease (i.e. stroke, psychosis, etc.)
- Non-native English speaker
- Severe visual or auditory disorder
- Sensitivity to sulfites (some propofol formulations at MGH may contain sodium metasulfite).
- Asthma (sulfite sensitivity is seen more frequently in asthmatic than in non-asthmatic people).
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
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Isoflurane Anesthesia
Recruited subjects that were anesthetized with isoflurane for their surgery.
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Sevoflurane Anesthesia
Recruited subjects that were anesthetized with sevoflurane for their surgery.
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Desflurane Anesthesia
Recruited subjects that were anesthetized with desflurane for their surgery.
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Propofol Anesthesia
Recruited subjects that were anesthetized with propofol for their surgery.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Cognitive Function
Time Frame: 1 week pre-operatively to 1 year post-operatively
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Cognitive function will be assessed using a battery of neuropsychological tests in the domains of attention and executive functions (Trail Making Test, Verbal Fluency Test, Category Switching Test, Symbol Digit Modalities Test), memory (Hopkins Verbal Learning Test-R, Brief Visual Memory Test-R), visuospatial functions (Benton Judgement of Line Orientation Test), and language (Category Fluency Test).
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1 week pre-operatively to 1 year post-operatively
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Anticipated)
October 1, 2013
Primary Completion (Anticipated)
December 1, 2018
Study Completion (Anticipated)
December 1, 2018
Study Registration Dates
First Submitted
June 3, 2013
First Submitted That Met QC Criteria
June 5, 2013
First Posted (Estimate)
June 6, 2013
Study Record Updates
Last Update Posted (Actual)
August 16, 2018
Last Update Submitted That Met QC Criteria
August 14, 2018
Last Verified
August 1, 2018
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- MassGH-001
- HAT-12-237963 (Other Grant/Funding Number: Alzheimer's Association)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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