Effects of Heating Transfusion on Brain Function

Effects of Heating Transfusion on Brain Function of Surgical Patients

To inversitage whether routine warming of blood is harmful to brain fuction of sugical patients receiving massive transfusion.

Study Overview

• Status: Completed
• Conditions: Blood Transfusion

Detailed Description

Hypothermia is an effective therapeutic intervention to reduce hypoxic ischemia brain injury in animal experiments and in clinics.In a recent study, it has been shown that perioperative warming was associated with a higher incidence of cognitive dysfunction in elderly patients.Therefore, we hypothesised that perioperative heating transfusion have a side effect on brain function of surgical patients.

• Study Type: Observational
• Enrollment (Anticipated): 100

Contacts and Locations

Study Locations

• China
  • Ningxia
    • Yinchuan, Ningxia, China, 750004
      • General Hospital of Ningxia Medical University
    • Yinchuan, Ningxia, China, 750004
      • Ningxia Medical University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 80 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

adult paitents scheduled for major surgery.

Description

Inclusion Criteria:

• adult patients scheduled for major surgery under general anesthesia and they probably need a blood transfusion during the procedure.

Exclusion Criteria:•Patients with a history of stroke, central nervous system disease , metabolic disturbance, psychiatric illness, hearing impairment, drug abuse or unwilling to participate in assessment

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Study Plan

How is the study designed?

Design Details

• Observational Models: Case-Control
• Time Perspectives: Prospective

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Brain fuction during perioperative period	Brain function includes cerebral blood flow and cerebral oxygen saturation	Change from baseline at post-transfusion 15min, 30min, 1hour, 2hour, 3 hour, 6hour, 12hour, 24hour

Secondary Outcome Measures

Outcome Measure	Time Frame
the cognitive performance and the score of postoperative quality recovery scales ( PQRS)	Chang from baseline at 15min,40min,1day,3day and 7day postoperative lay

Other Outcome Measures

Outcome Measure	Time Frame
serum concentration of inflammatory cytokine	change from baseline at 3hour, 6hour, 12hour, 24hour after transfusion

Collaborators and Investigators

• Sponsor: General Hospital of Ningxia Medical University
• Investigators: Study Director: Xinli Ni, Ningxia Medical University

Study record dates

Study Major Dates

• Study Start: June 1, 2012
• Primary Completion (Actual): December 1, 2013
• Study Completion (Actual): January 1, 2014

Study Registration Dates

• First Submitted: July 17, 2013
• First Submitted That Met QC Criteria: August 23, 2013
• First Posted (Estimate): August 28, 2013

Study Record Updates

• Last Update Posted (Estimate): July 11, 2014
• Last Update Submitted That Met QC Criteria: July 10, 2014
• Last Verified: July 1, 2014

More Information

Terms related to this study

• Keywords: Heating transfusion
• Other Study ID Numbers: NXKJGG2012