Non-surgical Periodontal Treatment on Hemogram, Lipid and Glycemic Profiles in Patients With Coronariopathies

Effects of Non-surgical Periodontal Treatment on Hemogram, Lipid and Glycemic Profiles of Patients With an Indication for Surgical Coronary Revascularization

Objective: The aim of this study was to examine the effects of non-surgical periodontal treatment on the hemogram, glycemic and lipid profiles in cardiopathic patients with an indication for surgical revascularization.

Materials and Methods: Twenty-two patients with chronic periodontitis, over 35 years of age (mean age 59.45 years) randomly assigned into 2 groups were evaluated. Test group (n=11), received periodontal treatment before the surgical procedure, and control group (n=11), did not received periodontal treatment prior to surgery.

Study Overview

• Status: Completed
• Conditions: Periodontitis; Coronariopathy
• Intervention / Treatment: Procedure: Periodontal treatment

• Study Type: Interventional
• Enrollment (Actual): 22
• Phase: Not Applicable

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 35 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Undergoing cardiovascular treatment;
• Eight viable teeth in the oral cavity;
• Four periodontal sites with periodontal probing depths ≥5mm in different teeth.

Exclusion Criteria:

-

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
No Intervention: Control
Experimental: Periodontal treatment; The test group received oral hygiene instructions, supragingival and subgingival scaling and root planning using curettes and an ultrasonic appliance.	Procedure: Periodontal treatment

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Reduction in probing depth in sites with PPD>3mm	Reduction of 11.4% in probing depth in sites with Periodontal Probing Depth>3mm	Baseline and 90 days after the initial exam
Reduction in probing depth in sites with PPD>5mm	Reduction of 6.3% in probing depth in sites with Periodontal Probing Depth>5mm	Baseline and 90 days after the initial exam
Reduction in probing depth in sites with CAL>3mm	Reduction of 4.6% in probing depth in sites with Clinical Attachment Level >3mm.	Baseline and 90 days after the initial exam
Reduction in probing depth in sites with CAL >5mm	Reduction of 3.6% in probing depth in sites with Clinical Attachment Level >5mm.	Baseline and 90 days after the initial exam
Leukocyte count	Non-significant reduction of leukocyte count in the test group. Mean difference of 74.6 m/mcL.	Baseline and 90 days after the initial exam
Glucose	Glucose showed a non-significant increase in the test group. Mean difference of 24.2 mg/dL.	Baseline and 90 days after the initial exam
Hemocyte	Hemocyte presented a non-significant reduction in the test group. Mean difference 0.39 m/mcL	Baseline and 90 days after initial exam
Hemoglobin	Non-significant reduction in test group. Mean difference of 0.2 g/dL	Baseline and 90 days after initial exam
Total Cholesterol	Significant reduction in the test group. Mean reduction of 27.4 mg/dL.	Baseline and 90 days after initial exam
High density lipid	Significant reduction in test group. Mean difference of 8.2 mg/dL.	Baseline and 90 days after initial exam
Low density lipid	Non-significant reduction in test group. Mean difference of 8.9 mg/dL.	Baseline and 90 days after initial exam

Collaborators and Investigators

• Sponsor: Universidade Veiga de Almeida
• Collaborators: Rio de Janeiro State Research Supporting Foundation (FAPERJ)

Study record dates

Study Major Dates

• Study Start: January 1, 2009
• Primary Completion (Actual): December 1, 2010

Study Registration Dates

• First Submitted: May 18, 2014
• First Submitted That Met QC Criteria: May 25, 2014
• First Posted (Estimate): May 29, 2014

Study Record Updates

• Last Update Posted (Estimate): May 29, 2014
• Last Update Submitted That Met QC Criteria: May 25, 2014
• Last Verified: May 1, 2014

More Information

Terms related to this study

• Keywords: cardiovascular diseases; periodontal diseases; periodontitis treatment
• Additional Relevant MeSH Terms: Stomatognathic Diseases; Periodontal Diseases; Mouth Diseases; Periodontitis
• Other Study ID Numbers: UVA71/06