Efficacy of Periodontal Treatment on Glycaemic Control in Diabetic Patients (DIAPERIO)

December 5, 2025 updated by: University Hospital, Toulouse
This study will assess the efficacy of periodontal treatment in diabetic patient. Patients will be randomized in the periodontal group or in the control group. The control group will received a periodontal treatment after the study.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

91

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • France
      • Bordeaux, France, 33000
        • UH Bordeaux
      • Toulouse, France, 31000
        • UHToulouse

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • patient suffering from a periodontitis
  • patient with : 7,0% < Hemoglobin A1c < 9,5%

Exclusion Criteria:

  • If an hospitalization is planned within the next 4 months
  • Patient suffering from chronic infectious pathology (HIV, hepatitis C virus, hepatitis B virus, mononucleosis)
  • Renal insufficiency
  • Contra indication for amoxicilline or clindamycin
  • Antithrombotic treatment
  • Liver disease

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: case
diabetic patients who will receive periodontal treatment blood sampling
Other: periodontal manual treatment
periodontal manual treatment
Experimental: control
diabetic patients without periodontal treatment (no periodontal treatment) blood sampling
Other: no periodontal manual treatment
blood sampling

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Hemoglobin A1c blood level
Time Frame: 3 months
efficacy of periodontal treatment on hemoglobin A1c
3 months

Other Outcome Measures

Outcome Measure
Measure Description
Time Frame
fructosamine blood level
Time Frame: 3 weeks
Compare the fructosamine content in blood between the 2 groups
3 weeks
Quality of life
Time Frame: 3 months
Compare the quality of life between the 2 groups using the 36-Item Short Form Health Survey (SF36)
3 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University Hospital, Toulouse

Investigators

  • Principal Investigator: Michel Sixou, MD, UH Toulouse

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

February 1, 2009

Primary Completion (Actual)

August 1, 2015

Study Completion (Actual)

August 1, 2015

Study Registration Dates

First Submitted

June 23, 2015

First Submitted That Met QC Criteria

September 29, 2015

First Posted (Estimated)

September 30, 2015

Study Record Updates

Last Update Posted (Estimated)

December 15, 2025

Last Update Submitted That Met QC Criteria

December 5, 2025

Last Verified

November 1, 2018

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 08 031 08

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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