- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02157896
Vascular Endothelial Growth Factor and Endostatin in Angiogenesis After Acute Ischemic Stroke
Dynamic Changes of Vascular Endothelial Growth Factor and Endostatin in Association With Circulating Endothelial Progenitor Cells After Acute Ischemic Stroke
Study Overview
Status
Conditions
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
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Shanghai, China, 200233
- Shanghai Sixth People's Hospital
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Clinical diagnosis of acute ischemic stroke
- Admission within 12 hours
- National Institutes of Health Stroke Scale score 6-25
Exclusion Criteria:
- Lacunar infarction
- Cerebral hemorrhagic infarction
- Epilepsy or epileptic persons
- History of neurological diseases, myocardial infarction, renal and hepatic abnormalities and metabolic diseases
- Contraindications to antiplatelet treatments
- Died within the first week of hospitalization
- Serial blood samples could not be obtained
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
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Acute ischemic stroke
Patients who suffered from acute ischemic stroke within 12 hours for the first time before entry into the study, and had a score between 6 and 25 on the National Institutes of Health Stroke Scale (NIHSS).
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
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Modified Rankin Scale scores
Time Frame: 3 months
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0 = No symptoms; 1 = No significant disability. Able to carry out all usual activities, despite some symptoms; 2 = Slight disability. Able to look after own affairs without assistance, but unable to carry out all previous activities; 3 = Moderate - Page 3 of 4 [DRAFT] - disability. Requires some help, but able to walk unassisted; 4 = Moderately severe disability. Unable to attend to own bodily needs without assistance, and unable to walk unassisted; 5 = Severe disability. Requires constant nursing care and attention, bedridden, incontinent; 6 = Dead. |
3 months
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Glasgow Outcome Scale scores
Time Frame: 3 months
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Glasgow Outcome Scale 1 = death; Glasgow Outcome Scale 2 = vegetative state; Glasgow Outcome Scale 3 = severe neurological deficit; Glasgow Outcome Scale 4 = mild neurological deficit and Glasgow Outcome Scale 5 = premorbid level of functioning or completely recovery.
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3 months
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Collaborators and Investigators
Sponsor
Investigators
- Study Director: Lixia Xue, M.D., Ph.D., Shanghai 6th people's hospital
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- H1583-660110
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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