A Dose Proportionality and Bioavailability Assessment of Buprenorphine Transdermal Delivery System Second Generation Patches

A Four-period, Randomised, Open-label, Crossover, Pharmacokinetic Study to Assess the Dose Proportionality and Relative Bioavailability of Buprenorphine Transdermal Delivery System Second Generation Patches Compared to First Generation Patches, in Healthy Volunteers

The purpose of this study is to obtain pharmacokinetic data for a dose proportionality and relative bioavailability assessment of 2nd generation BTDS patches compared to 1st generation BTDS patches.

Study Overview

• Status: Completed
• Conditions: Pain
• Intervention / Treatment: Drug: Second generation BTDS patch; Drug: First generation BuTrans patch

Detailed Description

The objective is to examine a new 2nd generation BTDS patch formulation at 2 strengths: 3.15 mg and 12.6 mg, compared to 1st generation patches at 2 strengths: 5 mg and 20 mg, to assess dose proportionality and relative bioavailability before proceeding to a definitive program of studies. Determination is by measurement of drug concentrations in the blood at serial collection time points pre-dose until 288 hours post-patch application.

• Study Type: Interventional
• Enrollment (Actual): 20
• Phase: Phase 1

Contacts and Locations

Study Locations

• United Kingdom
  • Nottingham, United Kingdom
    • Quotient Clinical LTD

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 55 years (ADULT)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria

1. Provide written informed consent.
2. Healthy male or female subjects aged 18 to 55 inclusive.
3. Female subjects of child bearing potential must be willing to use two highly effective methods of contraception throughout the study, one of which must include a barrier method. .
4. Male subjects who are willing to use contraception with their partners throughout the study and for 30 days after completion of the study and agree to inform the Investigator if their partner becomes pregnant during this time.
5. Body weight ranging from 55 to 100 kg and a BMI ≥ 18.5 and ≤ 29.9.
6. Healthy and free of significant abnormal findings as determined by medical history, physical examination, vital signs, laboratory tests and ECG.
7. Willing to eat all the food supplied throughout the study.
8. The subject's primary care physician has confirmed within the last 12 months that there is nothing in the subject's medical history that would preclude their enrolment into a clinical study.
9. Will refrain from strenuous exercise during the entire study.

Exclusion criteria

1. Female subjects who are pregnant or lactating.
2. Any history of drug or alcohol abuse.
3. Any history of conditions that might interfere with drug absorption, distribution, metabolism or excretion.
4. Use of opioid or opioid antagonist-containing medication in the past 30 days.
5. Any history of frequent nausea or vomiting regardless of aetiology.
6. Any history of seizures or symptomatic head trauma.
7. Participation in a clinical drug study during the 90 days preceding the initial dose in this study, participation in the previous Mundipharma Research Ltd, BUP1505 study or participation in any other study during this study.
8. Any significant illness during the 4 weeks preceding entry into this study.
9. A history of additional risk factors for Torsades de Pointes (e.g. heart failure, hypokalaemia, personal or family history of long QT syndrome, syncope, or family history of sudden death).
10. Abnormal cardiac conditions including any of the following:
11. Use of medication within 5 times the half-life or minimum 14 days for prescription medication or 7 days for over-the-counter preparations (including vitamins, herbal and/or mineral supplements), whichever is longer, before the first dose of study treatment and during the study (with the exception of the continued use of HRT and contraceptives).
12. Refusal to abstain from caffeine or xanthine containing beverages and grapefruit juice within 48 hours before IMP administration until after the last study PK sample has been taken in each study period.
13. Weekly alcohol intake exceeding the equivalent of 14 units/week for females and 21 units/week for males.
14. Consumption of alcoholic beverages within 48 hours before IMP administration, and refusal to abstain from alcohol for the duration of the study confinement and for at least 48 hours after the last naltrexone dose in each study period.
15. History of smoking within 45 days of IMP administration and refusal to abstain from smoking during the study.
16. Blood or blood products donated within 90 days prior to IMP administration or any time during the study, except as required by this protocol.
17. Positive results of urine drug screen, alcohol test, pregnancy test, HBsAg, Hepatitis C antibody, or HIV tests.
18. Known sensitivity to buprenorphine, naltrexone, related compounds or any of the excipients or any contraindications as detailed in the Butrans Summary of Product Characteristics or Nalorex Summary of Product Characteristics.
19. Clinically significant history of allergic reaction to wound dressings or elastoplast.
20. Subjects with any dermatological disorder or tattoos at the proposed sites of patch application, or with a history of eczema/cutaneous atrophy.
21. Subjects who will not allow hair to be removed at the proposed patch application sites which may prevent proper placement of the patch.
22. Refusal to allow their primary care physician to be informed.

Study Plan

How is the study designed?

Design Details

• Allocation: RANDOMIZED
• Interventional Model: CROSSOVER
• Masking: NONE

Number of Arms

4

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
EXPERIMENTAL: Treatment A; Second generation patch BTDS 12.6mg	Drug: Second generation BTDS patch
EXPERIMENTAL: Treatment B; Second generation patch BTDS 3.15mg	Drug: Second generation BTDS patch
ACTIVE_COMPARATOR: Treatment C; First generation patch BuTrans 20mg	Drug: First generation BuTrans patch
ACTIVE_COMPARATOR: Treatment D; First generation patch BuTrans 5mg	Drug: First generation BuTrans patch

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Pharmacokinetics parameters	AUC and Cmax	Up to 288 hours

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Adverse events	AEs will be recorded through spontaneous reporting	7 to 10 days

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
Vital Signs composite measure	Vital signs are collected as a composite measure- blood pressure, pulse rate, tympanic temperature, respiration rate, SpO2	0-288 hours
Clinical Laboratory Tests	Blood samples will be taken at screening, pre dose, 192 hours, and post study medical for routine blood chemistry and urinalysis	Day 0 and Day 7-10
ECG	ECGs	Screening, pre dose, 72, 120, 168hours, and day 7-10

Collaborators and Investigators

• Sponsor: Mundipharma Research Limited

Study record dates

Study Major Dates

• Study Start: May 1, 2014
• Primary Completion (ACTUAL): August 1, 2014
• Study Completion (ACTUAL): August 1, 2014

Study Registration Dates

• First Submitted: June 4, 2014
• First Submitted That Met QC Criteria: June 9, 2014
• First Posted (ESTIMATE): June 10, 2014

Study Record Updates

• Last Update Posted (ESTIMATE): September 30, 2014
• Last Update Submitted That Met QC Criteria: September 29, 2014
• Last Verified: June 1, 2014

More Information

Terms related to this study

• Keywords: Pharmacokinetics; Healthy Volunteers
• Other Study ID Numbers: BUP1506; 2014-000691-26 (EUDRACT_NUMBER)