Effect of Normal Aging on Language Processing (SEMVIE)

Cognitive Mechanisms and Cerebral Substrate of Naming Impairment During Aging. Behavior and Neuroimaging Approaches.

The purpose of this study is to understand the effect of age on language abilities. The investigators aim at investigating the cerebral modifications that take place in normal aging, at the functional an anatomical level.

Study Overview

• Status: Terminated
• Conditions: Cognition

• Study Type: Observational
• Enrollment (Actual): 33

Contacts and Locations

Study Locations

• France
  • Grenoble, France, 38000
    • IRMaGe facility

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 30 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

60 healthy adults will participate to the study. There will be 3 age groups: 30-50, 50-70, > 70 years. Ech group will contain 20 volunteers.

The volunteers are recruited by means of ads on Laboratory websites and Universities.

Description

Inclusion Criteria:

• Age of 30 years and above
• Right handed
• French native speakers
• Affiliation to French social security (Sécurité Sociale)
• Medical interview
• Consent form signed

Exclusion Criteria:

• Cerebral or respiratory pathologies
• Any MRI contrindication

Study Plan

How is the study designed?

Design Details

• Observational Models: Other
• Time Perspectives: Prospective

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
Healthy adults; 20 young adults aged between 30 and 50 years old. 20 middle aged adults aged between 50 and 70 years old. 20 older adults of 70 years old and more.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Blood Oxygen Level Dependent functional MRI	We use 3 functional tasks using block paradigm: Object naming, Verbal generation and semantic judgment, to elicit BOLD response using fMRI in order to compare functional activation patterns between subjects. We also use hypercapnic challenge to elicit BOLD response in order to obtain Cerebral Vascular Reactivity properties of subjects.	There will be a unique MRI measurement for each participant. Group analyses presentation after 1 year.
Anatomical MRI	We use Voxel Based Morphometry to compare cortical volume (grey matter) between subjects. We also use tractography Diffusion Tensor Imaging to compare white matter properties between subjects.	There will be a unique MRI measurement for each participant. Group analyses presentation after 1 year.

Collaborators and Investigators

• Sponsor: University Hospital, Grenoble
• Investigators: Principal Investigator: Alexandre Krainik, Professor, Neuroradiology department, Grenoble Hospital, INSERM, Grenoble University.; Study Director: Monica Baciu, Professor, Laboratory of Psychology and NeuroCognition, CNRS, Grenoble University.

Study record dates

Study Major Dates

• Study Start: July 1, 2014
• Primary Completion (Actual): July 1, 2018
• Study Completion (Actual): July 1, 2018

Study Registration Dates

• First Submitted: July 3, 2014
• First Submitted That Met QC Criteria: July 10, 2014
• First Posted (Estimate): July 14, 2014

Study Record Updates

• Last Update Posted (Actual): October 12, 2018
• Last Update Submitted That Met QC Criteria: October 9, 2018
• Last Verified: October 1, 2018

More Information

Terms related to this study

• Keywords: Cognition
• Other Study ID Numbers: 2014-AZ00569-38