Effect of Phosphorus Supplementation on Body Weight

Premeal Phosphorus Supplementation for Reducing Energy Intake and Body Weight

Phosphorus is a mineral that is naturally present in our foods and is required by our bodies for normal function. It has been found that phosphorus supplementation taken before meals has the potential to reduce meal size. However its long term effect has not been measured yet. It is well accepted that changes in body weight require about 3 months. Using body weight as the outcome, which is the ultimate outcome of weight loss approaches, would provide robust information on the role of phosphorus.

Study Overview

• Status: Completed
• Conditions: Body Weight
• Intervention / Treatment: Dietary supplement: phosphorus

Detailed Description

A double-blind, randomised, placebo-controlled trial of 63 adults aged 18 to 45 years with a body mass index (BMI) of 25 kg/m2 or higher and normal kidney function at the American University of Beirut. Participants were randomly assigned to the placebo or phosphorus group where daily placebo or phosphorus supplements were ingested with three main meals (breakfast, lunch, and dinner) for a period of 12 weeks. Primary outcomes were changes in anthropometric measures, blood metabolites (including lipid profile, glucose, and insulin), and subjective appetite scores.

• Study Type: Interventional
• Enrollment (Actual): 71
• Phase: Not Applicable

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 45 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• BMI>25
• CR>1mg/dl for women; Cr >1.2 mg/dl for men
• GFR >60ml/min/1.73m2

Exclusion Criteria:

• BMI<25
• presence of any significant medical disease,
• pregnancy or lactation,
• regular administration of drugs that affect body weight, and
• weight loss of 3% or more within 3 months of study entry.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Double

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: phosphorus; phosphorus ingestion (375mg) with each main meal ( breakfast, lunch, dinner)	Dietary supplement: phosphorus; phosphorus supplement
Placebo Comparator: placebo; ingestion of placebo tablets with each meal ( breakfast, lunch, dinner)	Dietary supplement: phosphorus; phosphorus supplement

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Body Weight	3 months

Secondary Outcome Measures

Outcome Measure	Time Frame
Waist Circumference	3 months
Appetite Score on the Visual Analog Scale	6 weeks

Collaborators and Investigators

• Sponsor: American University of Beirut Medical Center
• Investigators: Principal Investigator: Omar Obeid, PhD, AUB

Publications and helpful links

General Publications

• Ayoub JJ, Samra MJ, Hlais SA, Bassil MS, Obeid OA. Effect of phosphorus supplementation on weight gain and waist circumference of overweight/obese adults: a randomized clinical trial. Nutr Diabetes. 2015 Dec 21;5(12):e189. doi: 10.1038/nutd.2015.38.

Study record dates

Study Major Dates

• Study Start: June 1, 2013
• Primary Completion (Actual): June 1, 2014
• Study Completion (Actual): September 1, 2014

Study Registration Dates

• First Submitted: December 30, 2014
• First Submitted That Met QC Criteria: December 31, 2014
• First Posted (Estimate): January 1, 2015

Study Record Updates

• Last Update Posted (Estimate): January 8, 2016
• Last Update Submitted That Met QC Criteria: January 7, 2016
• Last Verified: January 1, 2015

More Information

Terms related to this study

• Keywords: phosphorus intake
• Additional Relevant MeSH Terms: Body Weight
• Other Study ID Numbers: NUT:00.11