- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02350153
Cushing´s Disease Epidemiology in Sweden
National Swedish Study in Cushing´s Disease Incidence and Outcomes
Study Overview
Status
Conditions
Detailed Description
This study is a retrospective nationwide study of all patients in Sweden with diagnosis CD between 1987 and 2013 were baseline data at diagnosis, information about the different treatments and follow-up data is going to be obtained by reviewing patients' medical journals. This information as well as the exact diagnose criteria for each patient are going to be extracted by Endocrinologists in all University Hospitals in Sweden. An expert group at the Sahlgrenska University Hospital in Gothenburg will put together the data.By the use of the Swedish Personal Number, the investigators are going to obtain information about both patients' and background population co-morbidities which have been collected in the different Swedish Registers.
Primary aim:
To study mortality of CD in Sweden.
Secondary aims:
- To study the influence of CD on myocardial infarction
- To study the influence of CD on stroke
- To study the influence of CD on cancer
- To study the influence of CD on hip fracture risk
- To study incidence and prevalence of CD in Sweden.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
-
-
Vastra Gotaland Region
-
Gothenburg, Vastra Gotaland Region, Sweden, 413 45
- Sahlgrenska University Hospital
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- All patients registered with Cushing's Disease in Sweden since 1987 in the statistical database for in- and out-patients, at the Swedish National Board of Health and Welfare will be included in the study.
Exclusion Criteria:
- No
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
---|
Patients with verified Cushing's Disease
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Mortality
Time Frame: From date of diagnosis until the last day of December 2014 or date of death from any cause, whichever came first, assessed up to 20 years.
|
If event (death) has been occured during the observation period.
Data obtained by the Swedish Cause Of Death Register (Swedish Board of Health and Welfare)
|
From date of diagnosis until the last day of December 2014 or date of death from any cause, whichever came first, assessed up to 20 years.
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
influence of Cushing's Disease on myocardial infarction
Time Frame: From date of diagnosis until the last day of December 2014 or date of death from any cause, whichever came first, assessed up to 20 years
|
If event (myocardial infarction) has been occured during the observation period.Data obtained by the Swedish Register of In- and Out-patient Diagnoses (Swedish Board of Health and Welfare)
|
From date of diagnosis until the last day of December 2014 or date of death from any cause, whichever came first, assessed up to 20 years
|
influence of Cushing's Disease on stroke
Time Frame: From date of diagnosis until the last day of December 2014 or date of death from any cause, whichever came first, assessed up to 20 years
|
If event (stroke) has been occured during the observation period.Data obtained by the Swedish Register of In- and Out-patient Diagnoses (Swedish Board of Health and Welfare)
|
From date of diagnosis until the last day of December 2014 or date of death from any cause, whichever came first, assessed up to 20 years
|
influence of Cushing's Disease on cancer
Time Frame: From date of diagnosis until the last day of December 2014 or date of death from any cause, whichever came first, assessed up to 20 years
|
If event (cancer) has been occured during the observation period.Data obtained by the Swedish Register of Cancer Diagnoses (Swedish Board of Health and Welfare)
|
From date of diagnosis until the last day of December 2014 or date of death from any cause, whichever came first, assessed up to 20 years
|
influence of Cushing's Disease on hip fracture risk
Time Frame: From date of diagnosis until the last day of December 2014 or date of death from any cause, whichever came first, assessed up to 20 years
|
If event (hip fracture) has been occured during the observation period.Data obtained by the Swedish Register of Hip Fractures (Swedish Board of Health and Welfare)
|
From date of diagnosis until the last day of December 2014 or date of death from any cause, whichever came first, assessed up to 20 years
|
incidence of Cushing's Disease in Sweden
Time Frame: Assessed up to 20 years.
|
Validation of Data obtained by The Swedish Board of Health and Welfare by reviewing all patients' journals
|
Assessed up to 20 years.
|
prevalence of Cushing's Disease in Sweden
Time Frame: Assessed up to 20 years.
|
Validation of Data obtained by The Swedish Board of Health and Welfare by reviewing all patients' journals
|
Assessed up to 20 years.
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Gudmundur Johannsson, Professor, Vastra Gotaland Region, Sahlgrenska University Hospital
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
- Brain Diseases
- Central Nervous System Diseases
- Nervous System Diseases
- Neoplasms by Histologic Type
- Neoplasms
- Neoplasms by Site
- Neoplasms, Glandular and Epithelial
- Endocrine System Diseases
- Endocrine Gland Neoplasms
- Hypothalamic Diseases
- Hyperpituitarism
- Pituitary Diseases
- Adenoma
- Pituitary Neoplasms
- ACTH-Secreting Pituitary Adenoma
- Pituitary ACTH Hypersecretion
Other Study ID Numbers
- NSSCDIO
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Cushing Disease
-
University of LeedsCompletedAdrenal; Insufficiency Gluccorticoid-Induced | Cushing; Syndrome or Disease, Glucocorticoid-Induced
-
Centre hospitalier de l'Université de Montréal...Recordati Rare DiseasesActive, not recruitingEndogenous Cushing SyndromeCanada
-
Sparrow PharmaceuticalsRecruitingAutonomous Cortisol Secretion (ACS) | ACTH-Independent Cushing Syndrome | ACTH-Independent Adrenal Cushing Syndrome, SomaticUnited States, United Kingdom, France, Romania
-
National Cancer Institute (NCI)Not yet recruitingHyperaldosteronism | Hypercortisolism | Cushing s SyndromeUnited States
-
Memorial Sloan Kettering Cancer CenterRecruitingCushing Syndrome | Cushing's Disease | Cushing DiseaseUnited States
-
HRA PharmaRecruitingCushing SyndromeSweden, France, Croatia, Spain
-
RECORDATI GROUPActive, not recruitingCushing's SyndromeUnited States, Argentina, Austria, Belgium, Brazil, Bulgaria, Canada, China, Costa Rica, France, Germany, India, Italy, Japan, Korea, Republic of, Poland, Russian Federation, Spain, Thailand, Turkey
-
Eunice Kennedy Shriver National Institute of Child...Completed
-
Corcept TherapeuticsCompletedCushing's SyndromeUnited States
-
HRA PharmaCompletedCushing's SyndromeGermany, Belgium, Italy, Hungary, Poland, Romania, Spain, Turkey