- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02369328
Multimodal MRI Study of Ischemic Stroke
August 23, 2016 updated by: Assistance Publique Hopitaux De Marseille
Stroke is the second most frequent causes of mortality in the word after cardiovascular disease and the most frequent cause of disability.
The majority of strokes are ischemic (87%).
Ischemic stroke may benefit from efficient therapy if the delay from stroke onset not exceeds 4H30 (intra-venous thrombolysis).
In case of irreversible cerebral lesion, the long term functional recovery is largely dependent from the ability of the brain to reorganize.
Conventional magnetic resonance imaging represents the most sensitive tool to diagnose stroke at the acute phase.
However, up to now, no imaging tool is available to determine the time of stroke onset.
Moreover, no imaging tool is available to precisely quantify the functional and structural plasticity mechanisms occurring after stroke.
The main objective of the present study is to test the accuracy of sodium MRI to determine the time of stroke onset.
The secondary objectives of the study are to determine the ability of non-conventional MRI techniques to quantify the degree of tissue damage and brain reorganization after stroke.
Thirty patients will be included during the first 24 hours after stroke onset.
Multimodal MRI (including perfusion MRI, sodium MRI, resting-state functional MRI, high resolution anatomical MRI) and clinical evaluation will be carried on at the inclusion, after 24 hours, at 3 months and at 12 months.
Study Overview
Study Type
Interventional
Enrollment (Anticipated)
60
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: BERTRAND AUDOUIN, MD
- Email: b.audoin@ap-hm.fr
Study Locations
-
-
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Marseille, France, 13005
- Recruiting
- Assistance Publique Hopitaux de Marseille
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Patient having presented a cerebral infarct beforehand confirmed by the brain imaging
- Patient having presented a cerebral infarct the hour of the beginning of which is known with certainty and dating less than 24 hours
- Patient having presented a cerebral infarct the area(extent) of which is superior to 1,5 ml
Exclusion Criteria:
- Patients presenting the usual contraindications to the MRI (pacemaker, agitation, metallic brightness, claustrophobia etc.)
- Patients presenting a risk of not compliance to the examination: disorders(confusions) of the elementary understanding, the confusion, the involuntary movements, the bad tolerance of the prolonged dorsal decubitus
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Diagnostic
- Allocation: Non-Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: multimodal MRI
Multimodal MRI (including perfusion MRI, sodium MRI, resting-state functional MRI, high resolution anatomical MRI) and clinical evaluation will be carried on at the inclusion, after 24 hours, at 3 months and at 12 months for patients whom suffering stroke
|
Multimodal MRI (including perfusion MRI, sodium MRI, resting-state functional MRI, high resolution anatomical MRI) will be carried on at the inclusion, after 24 hours, at 3 months and at 12 months and neurological clinical exam , rankin score, NIHSS
|
Active Comparator: multimocal MRI
Multimodal MRI (including perfusion MRI, sodium MRI, resting-state functional MRI, high resolution anatomical MRI) and clinical evaluation will be carried on at the inclusion, after 24 hours, at 3 months and at 12 months for healthy subjects
|
Multimodal MRI (including perfusion MRI, sodium MRI, resting-state functional MRI, high resolution anatomical MRI) will be carried on at the inclusion, after 24 hours, at 3 months and at 12 months and neurological clinical exam , rankin score, NIHSS
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
The time of stroke onset
Time Frame: 3 years
|
The main objective of the present study is to test the accuracy of sodium MRI to determine the time of stroke onset
|
3 years
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
The degree of tissue damage and brain reorganization after stroke
Time Frame: 3 years
|
The secondary objectives of the study are to determine the ability of non-conventional MRI techniques to quantify the degree of tissue damage and brain reorganization after stroke.
|
3 years
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
February 1, 2015
Primary Completion (Anticipated)
February 1, 2018
Study Completion (Anticipated)
June 1, 2018
Study Registration Dates
First Submitted
February 16, 2015
First Submitted That Met QC Criteria
February 20, 2015
First Posted (Estimate)
February 23, 2015
Study Record Updates
Last Update Posted (Estimate)
August 24, 2016
Last Update Submitted That Met QC Criteria
August 23, 2016
Last Verified
August 1, 2016
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 2014-A01532-45
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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