Aetiology of Children With Bronchiectasis in China

Aetiology of Children With Bronchiectasis in China--A Multicenter Retrospective Study

This multicenter retrospective observation study is designed to investigate the etiology of children with bronchiectasis by review the medical records.

Study Overview

• Status: Unknown
• Conditions: Bronchiectasis

Detailed Description

This study is divided into two parts. Part I. Retrospective review the 10 years medical records of the children with bronchiectasis from every center, and investigate the etiology of the cases by the standard diagnostic process. Part II. All new cases of bronchiectasis which was confirmed diagnosed at every center from the beginning of the study are made the investigation of the etiology by the standard diagnostic process.

• Study Type: Observational
• Enrollment (Anticipated): 300

Contacts and Locations

Study Locations

• China
  • Beijing
    • Beijing, Beijing, China, 100045
      • Recruiting
      • Beijing Children's Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: No older than 18 years (ADULT, CHILD)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Children who was confirmed diagnosis as bronchiectasis at the certain hospitals (sponsor and collaborators)

Description

Inclusion Criteria:A included patient must be coincident at least one point of the four items of HRCT manifestations.

• Internal bronchial diameter greater than the accompanying pulmonary artery.
• lack of bronchial tapering
• bronchi visible in the peripheral 1cm of lung
• bronchial diameter greater than adjacent segmental bronchi

Exclusion Criteria:Subject will be excluded if she or he has one of the following

• It is unable to provide complete medical records or the current condition can not accept the diagnosis process
• It does not agree to participate in the test

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Number of participants with differential causes of bronchiectasis by reviewing the medical records or undergoing the standard diagnostic process	The cause of each paticipant with bronchiectasis will be recorded, for example post infection, PCD, PID, et al.	48 months

Collaborators and Investigators

• Sponsor: Beijing Children's Hospital
• Collaborators: Shanghai Children's Medical Center; The Affiliated Hospital Of Guizhou Medical University; Jiangxi Province Children's Hospital; Yuying Children's Hospital of Wenzhou Medical University; Shenzhen Children's Hospital; The First Affiliated Hospital of Xiamen University; Children's Hospital of Chongqing Medical University; First Affiliated Hospital of Guangxi Medical University; Shanxi Provincial Maternity and Children's Hospital; Tianjin Children's Hospital; Changchun Children's Hospital; Wuhan women and children's health care center

Publications and helpful links

General Publications

• Barker AF. Bronchiectasis. N Engl J Med. 2002 May 2;346(18):1383-93. doi: 10.1056/NEJMra012519. No abstract available.
• Amorim A, Gracia Roldan J. Bronchiectasis: do we need aetiological investigation? Rev Port Pneumol. 2011 Jan-Feb;17(1):32-40. English, Portuguese.
• Gaillard EA, Carty H, Heaf D, Smyth RL. Reversible bronchial dilatation in children: comparison of serial high-resolution computer tomography scans of the lungs. Eur J Radiol. 2003 Sep;47(3):215-20. doi: 10.1016/s0720-048x(02)00122-5.
• Eastham KM, Fall AJ, Mitchell L, Spencer DA. The need to redefine non-cystic fibrosis bronchiectasis in childhood. Thorax. 2004 Apr;59(4):324-7. doi: 10.1136/thx.2003.011577.
• Brower KS, Del Vecchio MT, Aronoff SC. The etiologies of non-CF bronchiectasis in childhood: a systematic review of 989 subjects. BMC Pediatr. 2014 Dec 10;14:4. doi: 10.1186/s12887-014-0299-y.
• LIU Xiu-yun, JIANG Zai-fang. The etiology of ninety-one children with bronchiecatsis. J Clin Pediatr, 2011, 29(2):127-129.
• CHEN Jun, DUO Li-kun, WANG Xiao-feng. Clinical analysis of 22 children with bronchiectasis. J Clin Pediatr, 2012, 30(1):51-54.
• WANG Hao，XU Bao-ping，LIU Xiu-yun，HU Ying-hui，REN Yi-xin，SHEN Kun-ling. Clinical characteristics and follow-up of bronchiectasis in children. Chinese Journal of Practical Pediatrics, 2014;29 (12):936-939.

Study record dates

Study Major Dates

• Study Start: June 1, 2016
• Primary Completion (ANTICIPATED): March 1, 2022
• Study Completion (ANTICIPATED): March 1, 2022

Study Registration Dates

• First Submitted: September 14, 2015
• First Submitted That Met QC Criteria: September 20, 2015
• First Posted (ESTIMATE): September 22, 2015

Study Record Updates

• Last Update Posted (ESTIMATE): January 9, 2017
• Last Update Submitted That Met QC Criteria: January 6, 2017
• Last Verified: January 1, 2017

More Information

Terms related to this study

• Keywords: children; etiology
• Additional Relevant MeSH Terms: Respiratory Tract Diseases; Bronchial Diseases; Bronchiectasis
• Other Study ID Numbers: BCHlung002