MRI Biomarkers and Exercise

December 6, 2019 updated by: University of Wisconsin, Madison

MRI Biomarkers of Risk in Sedentary and Exercise Trained Humans

The overall goal of observational study is to examine the age-related and habitual exercise training status-related differences in structural and functional changes in the human brain, detected by magnetic resonance (MR) imaging.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Normal aging reduces cerebral blood flow, brain volume, and cognitive function, thereby increasing the risk of dementia or Alzheimer's disease. Aging is associated with increased white matter hyperintensities (WMH) and appears to alter functional connectivity within the brain both of which associated with cognitive function (references). Observational studies suggest that regular physical activity is associated with improved cognitive function and higher cerebral blood flow 1,2. However, it is unknown if aging or exercise training status alters the structural and functional biomarkers that are predictive of cognitive decline. Thus, the overall goal of this project is to examine the age-related and exercise training status-related differences in structural and functional changes in the brain, detected by magnetic resonance (MR) imaging.

  1. To determine if white matter hyperintensities on MRI scans of the brain are altered by aging and exercise training status.
  2. To determine the interaction of aging and habitual physical activity on functional connectivity in the brain.

Study Type

Observational

Enrollment (Actual)

71

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • Wisconsin
      • Madison, Wisconsin, United States, 53716
        • Gymnasium-Natatorium

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 75 years (ADULT, OLDER_ADULT)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Subjects for this study will include healthy young adults (18-35 years old), sedentary older adults (55-75 years old), and healthy exercise trained older adults (55-75 years old). Both men and women will be eligible to participate in this study.

Description

Inclusion Criteria:

  • Between 18-35 or 55-75
  • Body mass index <34 kg/m2
  • Physically active (exercise more than 3 times per week for at least 30 min) or sedentary (no formal exercise over 1 hour per week)

Exclusion Criteria:

  • Current smoker
  • History or evidence of: hepatic disease, renal disease, hematological disease, peripheral vascular disease, stroke/neurovascular disease, diabetes, hypertension
  • Part of a vulnerable population (e.g. pregnant women, prisoner, individuals lacking capacity to consent, etc.)

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Exercise trained young adults
Exercise trained young adults between the age of 18-35 years.
Device: MRI
Participants will undergo an MRI scan
Sedentary young adults
Sedentary young adults between the age of 18-35 years.
Device: MRI
Participants will undergo an MRI scan
Exercise trained older adults
Exercise trained older adults between the age of 55-75 years.
Device: MRI
Participants will undergo an MRI scan
Sedentary older adults
Sedentary older adults between the age of 55-75 years.
Device: MRI
Participants will undergo an MRI scan

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
White Matter Hyperintensity Volume
Time Frame: 60 minutes
Utilize an MRI to measure brain volume when participant is at rest
60 minutes

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Default Mode Network Connectivity
Time Frame: 60 minutes
Utilize an MRI to measure functional connectivity in the brain when participant is at rest
60 minutes
Middle Cerebral Artery Blood Flow Scan
Time Frame: 60 minutes
Utilize an MRI to measure middle cerebral artery blood flow in the brain when the participant is at rest
60 minutes

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Wisconsin, Madison

Collaborators

National Institutes of Health (NIH)

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (ACTUAL)

April 1, 2016

Primary Completion (ACTUAL)

April 1, 2019

Study Completion (ACTUAL)

April 1, 2019

Study Registration Dates

First Submitted

March 24, 2016

First Submitted That Met QC Criteria

March 30, 2016

First Posted (ESTIMATE)

April 6, 2016

Study Record Updates

Last Update Posted (ACTUAL)

December 9, 2019

Last Update Submitted That Met QC Criteria

December 6, 2019

Last Verified

December 1, 2019

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • 2015-1611
  • A176000 (Other Identifier: UW Madison)
  • EDUC/KINESIOLOGY/KINESIO (Other Identifier: UW Madison)
  • CVR-AAA4385 (Other Identifier: UW-Madison Study Staff)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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