Brain Blood Flow Responses During Exercise

October 26, 2023 updated by: University of Wisconsin, Madison

Influence of Biological Sex and Age on Cerebral Blood Flow and Vessel Function During Exercise: a Pilot Study

Brain blood flow will be measured during exercise using magnetic resonance imaging.

Study Overview

Status

Enrolling by invitation

Conditions

Intervention / Treatment

Detailed Description

Over 6 million Americans are living with Alzheimer's disease and related dementias and this number is expected to reach over 13 million by 2060. Thus, there is an urgent need for interventions to prevent the development and progression of Alzheimer's disease and related dementias. Regular exercise is currently the most promising strategy as it is repeatedly shown to have neuroprotective benefits. Evidence suggests that the neuroprotective effects of exercise is the result of improved health of blood vessels. Despite the vast amount of evidence on the benefit of exercise on the peripheral vasculature, there is little information regarding brain vascular responses during exercise. This study will investigate the impact of exercise at varying intensities on brain blood flow during exercise, and will also examine the influence of age and sex.

Study Type

Observational

Enrollment (Estimated)

85

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • Wisconsin
      • Madison, Wisconsin, United States, 53706
        • University of Wisconsin-Madison

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Sampling Method

Non-Probability Sample

Study Population

Participants for this study will include healthy adults with a history of engaging in regular physical activity. Both men and women, between 20-40 or 55-69 years, are eligible to participate in this study.

Description

Inclusion Criteria:

  • Healthy men or women between the ages of 20-40 year or 55-69 years
  • Demonstrate an exercise history of engaging in aerobic physical activity at least 3 times per week for a minimum of 30 continuous minutes
  • Have experience using cardiovascular exercise equipment (e.g., treadmill, elliptical, upright or recumbent bicycle, stair-stepper)

Exclusion Criteria:

  • Outside of specified age range
  • Do not have experience using cardiovascular exercise equipment
  • Do not meet the physical activity criteria
  • Present with a history or evidence of hepatic, renal, hematological disease, cardiovascular disease including uncontrolled hypertension, peripheral vascular disease, stroke/neurovascular disease, and diabetes
  • have a body mass index ≥30 kg/m2
  • are ≥ 71 inches (180 cm) in height
  • have any contraindications to MRI
  • currently use or have a history of use of tobacco or illegal substances
  • have current and/or a history of depression or other mood related disorders (those with mild depression and/or anxiety that is controlled with medication and/or therapy will not be excluded)
  • vulnerable populations (e.g., pregnant women, prisoners, individuals lacking capacity to consent)
  • if the desired moderate/vigorous exercise intensity corresponds to > 350 watts on the stepper device

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Young Adults
Young Adults between 20-40 years of age.
Device: MRI
Participants will undergo an MRI scan while performing exercise at two intensities (light and moderate/vigorous) using an MRI-compatible stepper device.
Middle-Aged Adults
Middle-Aged Adults between 55-69 years of age.
Device: MRI
Participants will undergo an MRI scan while performing exercise at two intensities (light and moderate/vigorous) using an MRI-compatible stepper device.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Cerebral Artery Dilation
Time Frame: One study visit, up to 120 minutes
The change in cross-sectional area of the cerebral arteries during exercise will be measured with MRI.
One study visit, up to 120 minutes
Cerebral Blood Flow
Time Frame: One study visit, up to 120 minutes
The change in intracranial blood flow during exercise will be measured with MRI.
One study visit, up to 120 minutes

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Wisconsin, Madison

Collaborators

National Institute of Neurological Disorders and Stroke (NINDS)

Investigators

  • Principal Investigator: Jill N Barnes, PhD, University of Wisconsin, Madison

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

April 18, 2023

Primary Completion (Estimated)

June 1, 2024

Study Completion (Estimated)

June 1, 2024

Study Registration Dates

First Submitted

May 8, 2023

First Submitted That Met QC Criteria

May 8, 2023

First Posted (Actual)

May 18, 2023

Study Record Updates

Last Update Posted (Actual)

October 27, 2023

Last Update Submitted That Met QC Criteria

October 26, 2023

Last Verified

October 1, 2023

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • 2022-0512
  • A176000 (Other Identifier: University of Wisconsin, Madison)
  • UWF (Other Identifier: University of Wisconsin Foundation)
  • 1RF1NS117746-01 (U.S. NIH Grant/Contract)
  • Protocol Version 3/22/2023 (Other Identifier: UW Madison)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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