The Causative Insects in Severe Insect Sting Allergy

May 4, 2016 updated by: Nualanong Visitsunthorn, Mahidol University

Evaluating the Causative Insects in the Cases With Severe Insect Sting Allergy

Study the causative insect by skin prick test and sIgE to wasp, bee and fire ants are important but false positive by crossreactivity can occur. sIgE to recombinant venom allergen is proposed to help in finding the causative insect.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Insect sting allergy from insects in Hymenoptera is not uncommon. The reaction maybe very severe and life threatening. To find the cause of insect sting allergy is important in prevention and specific treatment such as immunotherapy. The skin prick test and sIgE of these insects may have cross reactions so it is difficult to be interpreted.

The usage of sIgE recombinant venom allergen can benefit in separate cross reaction and dual allergy reaction.

Study Type

Interventional

Enrollment (Actual)

20

Phase

  • Not Applicable

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Cases with severe insect sting allergy reactions

Exclusion Criteria:

  • Without other severe systemic diseases
  • Not pregnant or lactation

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Diagnostic
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Other: insect sting allergy

Skin prick tests to local and imported insect sting allergen with different concentration are performed.

sIgE Measurement (to insect and the recombinant venom)
Other: Skin prick test
Skin prick tests to local and imported insect sting allergen with different concentration are performed.
Other: sIgE measurement
sIgE levels to stinging insect allergen and their recombinant venom allergen are measured

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Mean wheal diameters of skin prick test of local and imported insect allergens
Time Frame: 12 months
Compare Mean wheal diameters of skin prick test of local and imported insect allergens at different concentrations
12 months

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
specific IgE level to stinging insect allergen and recombinant venom allergens
Time Frame: 12 months
compare skin prick test result and levels of specific IgE level to stinging insect allergen and recombinant venom allergens
12 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Mahidol University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

February 1, 2015

Primary Completion (Actual)

March 1, 2016

Study Completion (Actual)

April 1, 2016

Study Registration Dates

First Submitted

May 4, 2016

First Submitted That Met QC Criteria

May 4, 2016

First Posted (Estimate)

May 6, 2016

Study Record Updates

Last Update Posted (Estimate)

May 6, 2016

Last Update Submitted That Met QC Criteria

May 4, 2016

Last Verified

May 1, 2016

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Si063/2557

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Insect Sting Allergy

Clinical Trials on Skin prick test

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Georgia

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

3
Subscribe