Olfactory and Visual Perception in Depressed Patients (PERODEP)

August 2, 2016 updated by: Centre Hospitalier Universitaire de Besancon

Study of the Emotional Reactivity to Olfactive and Visual Perception in Depressed Patients

The study aimed to determine the emotional reactivity of depressed patients to visual and olfactory stimuli in comparison with healthy volunteers.

Study Overview

Status

Terminated

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

3

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • France
    • Doubs
      • Besancon, Doubs, France, 25030
        • CHU Besançon

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 65 years (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • no cognitive impairment that could prevent instruction comprehension
  • no more than 10 cigarettes/day
  • signed informed consent
  • group 1: current major depressive disorder
  • group 2: no current major depressive disorder

Exclusion Criteria:

  • pregnancy
  • visual impairment
  • olfactory impairment

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Non-Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: depressed patients
patient with a current unipolar major depressive disorder intervention: olfactory assessment, image visualization and psychophysiological assessment
Behavioral: olfactory assessment
determination of olfactory sensitivity through olfactory threshold assessment (butanol) determination of hedonicity and intensity of 16 usual odors
Behavioral: image visualization
20 images (from the IAPS-international affective picture systems) are presented to the subject. He has to determine the hedonicity of each picture.
Behavioral: psychophysiological assessment
during the olfaction assessment and the image visualization, skin conductance reactivity (SCR) is recorded to assess unconscious emotional reactivity
Experimental: non depressed subject
subject without a current unipolar major depressive disorder intervention: olfactory assessment, image visualization and psychophysiological assessment
Behavioral: olfactory assessment
determination of olfactory sensitivity through olfactory threshold assessment (butanol) determination of hedonicity and intensity of 16 usual odors
Behavioral: image visualization
20 images (from the IAPS-international affective picture systems) are presented to the subject. He has to determine the hedonicity of each picture.
Behavioral: psychophysiological assessment
during the olfaction assessment and the image visualization, skin conductance reactivity (SCR) is recorded to assess unconscious emotional reactivity

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
hedonicity score of visual stimuli
Time Frame: up to 1 month
it will be compared between depressed and non depressed subjects.
up to 1 month
skin conductance reactivity amplitude
Time Frame: up to 1 month
it will be compared between depressed and non depressed subjects.
up to 1 month
Skin conductance reactivity reaction time
Time Frame: up to 1 month
it will be compared between depressed and non depressed subjects.
up to 1 month
hedonicity score of olfactory stimuli
Time Frame: up to 1 month
it will be compared between depressed and non depressed subjects.
up to 1 month

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Centre Hospitalier Universitaire de Besancon

Investigators

  • Principal Investigator: Sylvie Nezelof, MD PhD, Centre Hospitalier Universitaire de Besançon

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

February 1, 2014

Primary Completion (Actual)

April 1, 2014

Study Completion (Actual)

April 1, 2016

Study Registration Dates

First Submitted

July 26, 2016

First Submitted That Met QC Criteria

August 2, 2016

First Posted (Estimate)

August 5, 2016

Study Record Updates

Last Update Posted (Estimate)

August 5, 2016

Last Update Submitted That Met QC Criteria

August 2, 2016

Last Verified

August 1, 2016

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • P/2011/126

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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