- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02902692
Mindfulness for Older Adults With Cognitive Concerns
Examining the Effects of a Brief Mindfulness Based Intervention (BMBI) on Mood and Cognitive Functioning in an Older Adult Population
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
-
London, United Kingdom, SE5 8AF
- Recruiting
- South London and Maudsely NHS Memory Services
-
Contact:
- Rebecca Gould, PHD
- Phone Number: 02078480346
- Email: rebecca.gould@kcl.ac.uk
-
Contact:
- David Matthews, PHD
- Phone Number: 02032289500
- Email: david.matthews@slam.nhs.uk
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:People aged 50 years and older with subjective memory concerns (SMC) and/or those who meet criteria for amnestic mild cognitive impairment (MCI) who have been seen by one of the three SLAM memory services (i.e. Croydon Memory Service; Southwark and Lambeth Memory Service; and Lewisham Memory Service) in the past three months. Participants must be able to give informed consent to participate.
-
Exclusion Criteria: Diagnosis of dementia or multi-domain mild cognitive impairment, intellectual disability, current substance misuse, a current diagnosis of epilepsy or another neurodegenerative disorder (such as Parkinson's), a history of brain injury or stroke, a severe and enduring mental health disorder (e.g. severe depression or anxiety, personality disorder, schizophrenia, schizoaffective disorder, bipolar affective disorder), active suicidal ideation, severe sensory impairment that would significantly impair a person's ability to engage in the intervention.
-
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Supportive Care
- Allocation: Randomized
- Interventional Model: Single Group Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Brief Mindfulness
45 minute brief mindfulness intervention (lead by study investigator) on day 1 followed by 7 days of 30 minute mindfulness practice at home (without study investigator)
|
15 minutes psycho-education about mindfulness and a small experiential exercise using a raisin.
Following this, participants listen to a 30minute pre-recorded sitting meditation which encourages them to focus on their breath and the sounds around them.
Participants will be randomly assigned to either receive the brief mindfulness intervention immediately or will be asked to wait one week before receiving the intervention.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Test of Everyday Attention
Time Frame: Change in attention from Baseline to 1 Week
|
The Test of Everyday Attention (TEA): Two subtests from the TEA (Robertson et al., 1994) will be used in the current study.
Specifically, the Elevator Test will be used to measure sustained attention and the Visual Elevator Test will be used as a measure of attentional switching, and hence of cognitive flexibility.
The TEA subtests are based on everyday life scenarios offering greater ecological validity.
It has parallel forms which allow for repeat administration within short time periods reducing the impact of practice effects.
|
Change in attention from Baseline to 1 Week
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Hospital Anxiety Depression Scale (HADS)
Time Frame: Change in anxiety and depression from Baseline to 1 Week
|
The HADS consists of two subscales measuring depression and anxiety respectively.
Each subscale consists of seven items and responses on the items are based on the relative frequency of symptoms over the past week using a four point Likert scale ranging from 0 (not at all) to 3 (very often indeed).
Higher scores indicate higher levels of depression and anxiety, and scores of about 10 on each subscale indicate clinical significance.
|
Change in anxiety and depression from Baseline to 1 Week
|
Penn State Worry Questionnaire
Time Frame: Change in worry from Baseline to 1 Week
|
Penn State Worry Questionnaire: The PSWQ is a 16-item measure of worry that has shown adequate internal consistency and convergent validity in elderly patients with GAD and controls( Beck et al., 1995 and Stanley et al., 2001).
It uses a Likert rating from 1 (not at all typical of me) to 5 (very typical of me).
|
Change in worry from Baseline to 1 Week
|
Short Form Health Survey
Time Frame: Change in quality of life from Baseline to 1 Week
|
Short-Form Health Survey (SF-36): The physical and mental summary scores of the Short Form Health Survey (SF-36) (Van de Zee et al., 1993) are used to measure quality of life related to physical and mental aspects.
The SF-36 is composed of 36 items measuring health across eight dimensions: physical functioning, social functioning, role limitations due to physical problems, role limitations due to emotional problems, pain, mental health, vitality, and general health perception.
These eight subscales can be summarized into one physical and one mental component summary score.
Each dimension score ranges from 0-100.
Higher scores indicate better health-related quality of life.
|
Change in quality of life from Baseline to 1 Week
|
The Trail Making Test Parts A&B
Time Frame: Change in executive functioning from Baseline to 1 Week
|
The Trail Making Test (TMT; Army Individual Test Battery, 1944) is a commonly used neuropsychological test of visual attention and task switching.
It consists of 2 parts: part A asks participants to connect a series of numbers in ascending order on a page, while part B requires participants to draw a line alternating between ascending numbers and letters.
Part A is used primarily to capture processing speed whereas Part B requires more complex attention shifting, planning, and concentration, and is, thus, considered a valid index of executive control.
The time taken to complete the task is the primary performance outcome
|
Change in executive functioning from Baseline to 1 Week
|
Digit Span Task
Time Frame: Change in working memory from Baseline to 1 Week
|
Digit Span is a core working memory sub-test of the WAIS-IV (Wechsler, 2008).
It requires participants to repeat a series of digits forwards and backwards with series ranging in length from 2 to 9 digits.
This test also measures auditory sequential processing as the individual must recall auditory information and repeat it back aloud.
The Digit Span subtest has revealed an average test-retest reliability of .82
(Wechsler, 2008b).
|
Change in working memory from Baseline to 1 Week
|
Letter-Number Sequencing Task
Time Frame: Change in working memory from Baseline to 1 Week
|
Letter Number Sequencing is a subtest of the WAIS-IV (Wechsler, 2008) and is a measure of attention and short-term memory.
Lemay et al. (2004) report test-retest reliability data of between .73 and .75 in a two-week interval in middle aged to elderly subjects suggesting it can be reliably used in repeated neuropsychological assessments.
|
Change in working memory from Baseline to 1 Week
|
The Cognitive Failures Questionnaire
Time Frame: Change in subjective cognitive concerns from Baseline to 1 Week
|
The Cognitive Failures Questionnaire (Broadbent et al., 1982) will be used as a measure of subjective cognitive complaints.
The CFQ has been shown to have acceptable internal consistency and retest reliability, and good face validity in a sample of older adults (Knight et al., 2004).
|
Change in subjective cognitive concerns from Baseline to 1 Week
|
The Five Facet Mindfulness Questionnaire (FFMQ)
Time Frame: Change in mindfulness from Baseline to 1 Week
|
The Five Facet Mindfulness Questionnaire (FFMQ): The FFMQ (Baer et al., 2006) assesses five components of mindfulness: observing, describing, acting with awareness, non-judging of inner experience, and non-reactivity to inner experience.
It has been shown to have good internal consistency (Baer et al., 2006) and adequate construct validity (Baer et al., 2008).
|
Change in mindfulness from Baseline to 1 Week
|
Ruminative Response Scale of the Response Styles Questionnaire
Time Frame: Change in rumination from Baseline to 1 Week
|
Ruminative Response Scale of the Response Styles Questionnaire (RRS of RSQ; Nolen-Hoeksema & Morrow, 1991).
The RRS will be administered to assess participants' tendencies to ruminate in response to their symptoms of negative emotion.
The RRS includes 22 items in response to depressed mood that are self-focused (e.g., "I think why do I always react this way?"), symptom focused (e.g., "I think about how hard it is to concentrate"), and focused on the possible consequences and causes of mood (e.g., "I think I won't be able to do my job if I don't snap out of this"), which participants rate on a scale from 1 (never) to 4 (always).
Total scores range from 22 to 88 with higher scores indicating greater rumination.
|
Change in rumination from Baseline to 1 Week
|
Self-Compassion Scale Short-Form
Time Frame: Change in self-compassion from Baseline to 1 Week
|
Self-Compassion Scale Short-Form (SCS-SF): The SCS-SF (Raes, Pommier, Neff, & Van Gucht, 2011) measures self-compassion and it has the following sub-scales: self-kindness, self-judgment, common humanity, isolation, mindfulness, and over-identification.
Participants have to rate how often they behave in a stated manner (e.g., "When I'm going through a very hard time, I give myself the caring and tenderness I need") in a scale from 1 (almost never) to 5 (almost always).
Total scores range from 12 to 60 with higher scores indicating greater self-compassion
|
Change in self-compassion from Baseline to 1 Week
|
CORE-10
Time Frame: Change in general psychological functioning from Baseline to 1 Week
|
CORE-10.
The CORE-10 is a short, 10 item version of the CORE-OM, a standard measure of psychological distress
|
Change in general psychological functioning from Baseline to 1 Week
|
Discharge Satisfaction Questionnaire
Time Frame: Post-treatment
|
The Discharge Satisfaction Questionnaire, (a standard service measure used within the MHOA CAG) will be completed by both the mindfulness and WLC group at post-intervention only to evaluate service satisfaction and the acceptability of the mindfulness intervention
|
Post-treatment
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Rebecca Gould, PhD,DClinPsy, King's College London
Study record dates
Study Major Dates
Study Start
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 16/LO/0223
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Mild Cognitive Impairment
-
University of California, San FranciscoNational Institute on Aging (NIA)Active, not recruitingMild Cognitive Impairment | Cognitive Decline | Cognitive Deterioration | Cognitive Impairment, Mild | Cognitive Deficits, MildUnited States
-
Saglik Bilimleri UniversitesiAnkara UniversityRecruitingAmnestic Mild Cognitive Impairment | Amnestic Mild Cognitive DisorderTurkey
-
BaycrestCentre for Aging and Brain Health InnovationUnknownNeurocognitive Disorders | Cognitive Dysfunction | Mental Disorder | Cognitive Impairment, Mild | Cognitive Disorder | Nonamnestic Mild Cognitive ImpairmentCanada
-
Mackay Memorial HospitalBened Biomedical Co., Ltd.RecruitingMild Cognitive Impairment (MCI)Taiwan
-
Thomas Jefferson UniversityJohns Hopkins University; University of Pennsylvania; National Institute on Aging... and other collaboratorsCompletedMild Cognitive Impairment (MCI)United States
-
Palo Alto Veterans Institute for ResearchU.S. Army Medical Research and Development CommandCompletedAmnestic Mild Cognitive ImpairmentUnited States
-
Assaf-Harofeh Medical CenterNeurim Pharmaceuticals Ltd.UnknownMild Cognitive Impairment (MCI)Israel
-
Xuanwu Hospital, BeijingWuhan University; Beijing Friendship Hospital; First Affiliated Hospital Xi'an... and other collaboratorsRecruitingAmnestic Mild Cognitive ImpairmentChina
-
Immunotec Inc.RecruitingMild Cognitive Impairment (MCI)Canada
-
Jennifer BramenNational Institutes of Health (NIH); National Institute on Aging (NIA)CompletedAmnestic Mild Cognitive ImpairmentUnited States
Clinical Trials on Brief Mindfulness
-
Massachusetts General HospitalMayo Clinic; University of Pennsylvania; University of South Florida; University... and other collaboratorsCompleted
-
International Islamic University MalaysiaUniversitas Ahmad DahlanRecruitingStress, PsychologicalIndonesia
-
Canterbury Christ Church UniversityUniversity College, LondonCompletedMindfulness | New Mothers Well-beingUnited Kingdom
-
The Hong Kong Polytechnic UniversityRecruitingFrailty | Caregiver BurnoutHong Kong
-
Freie Universität BerlinCharite University, Berlin, GermanyCompletedMajor Depressive Disorder
-
Universiti Tunku Abdul RahmanSunway UniversityCompletedPsychological Distress | Mental Health Wellness | Psychological SecurityMalaysia
-
Istanbul Aydın UniversityCompletedDomestic ViolenceTurkey
-
VA Salt Lake City Health Care SystemCompletedSuicidal Ideation | Addiction | Psychiatric DisorderUnited States
-
Chinese University of Hong KongCity University of Hong KongCompleted
-
Universidad Santo Tomas, ChileUniversidad de ConcepcionCompletedDepressive Symptoms | Posttraumatic Stress Disorder | Acute Post-Traumatic Stress DisorderChile