The Effect of Blood Transfusion on Venoarterial PCO2 Difference in Cardiac Surgery

Venoarterial CO2 difference(delta PCO2), lactate, central venous oxygen saturation(ScVO2) will be recorded in several steps in coronary artery bypass graft and valvular cardiac operations. The patients will be divided into two groups as Transfused, and Non-Transfused Groups observationally. The trend of delta CO2, lactate, ScVO2, postoperative creatinine values, postoperative complications and 28 days mortality will be compared.

Study Overview

• Status: Completed
• Conditions: Cardiac Procedure Complication
• Intervention / Treatment: Biological: Blood transfusion

Detailed Description

Preoperative creatinine values, demographic data, comorbidities will be recorded in ASA I-II elective coronary artery and valvular cardiac surgery patients. Intraoperative delta PCO2, lactate, ScVO2 will be recorded in several steps. The patients will be divided into two groups as Transfused, and Non-Transfused Groups observationally. The trend of delta CO2, lactate, ScVO2, postoperative creatinine values, postoperative complications and 28 days mortality will be compared.

• Study Type: Observational
• Enrollment (Actual): 127

Contacts and Locations

Study Locations

• Turkey
  • Ankara, Turkey, 06230
    • Turkiye Yuksek Ihtisas Education and Research Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 75 years (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: N/A
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

18-75 years cardiac surgery patients

Description

Inclusion Criteria:

• Elective cardiac surgery, stable cardiac function

Exclusion Criteria:

• Clinical signs of heart failure, symptomatic cerebral or peripheral failure, uncontrolled diabetes mellitus

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Transfused; Patients who have blood transfusion during cardiac surgery	Biological: Blood transfusion; The transfusion of erythrocyte suspension
Not-Transfused; Patients who don't have blood transfusion during cardiac surgery

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Complication	The postoperative neurologic, renal, hepatic, respiratory complications	5 days

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Mortality	mortality	28 days

Collaborators and Investigators

• Sponsor: Turkiye Yuksek Ihtisas Education and Research Hospital
• Investigators: Study Chair: Demet Bölükbaşı, Specialist, Turkiye Yuksek Ihtisas Education and Research Hospital; Study Director: Sema Turan, Asc prof, Turkiye Yuksek Ihtisas Education and Research Hospital; Study Chair: Dilek Kazancı, Asc prof, Turkiye Yuksek Ihtisas Education and Research Hospital; Study Chair: Sultan Sevim Yakın, Specialist, Turkiye Yuksek Ihtisas Education and Research Hospital; Study Chair: Hija Yazıcıoğlu, Asc Prof, Turkiye Yuksek Ihtisas Education and Research Hospital; Study Director: Aysegül Özgok, Prof, Turkiye Yuksek Ihtisas Education and Research Hospital

Study record dates

Study Major Dates

• Study Start (ACTUAL): August 20, 2017
• Primary Completion (ACTUAL): November 1, 2017
• Study Completion (ACTUAL): December 1, 2017

Study Registration Dates

• First Submitted: August 8, 2017
• First Submitted That Met QC Criteria: August 9, 2017
• First Posted (ACTUAL): August 10, 2017

Study Record Updates

• Last Update Posted (ACTUAL): December 18, 2017
• Last Update Submitted That Met QC Criteria: December 14, 2017
• Last Verified: December 1, 2017

More Information

Terms related to this study

• Keywords: tissue oxygenation
• Other Study ID Numbers: 1297

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No