A Maintenance and Long-Term Extension Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Crohn's Disease Who Completed the Studies M14-431 or M14-433 (U-ENDURE)

April 6, 2026 updated by: AbbVie

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Maintenance and Long-Term Extension Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Subjects With Crohn's Disease Who Completed the Studies M14-431 or M14-433

A multicenter study to evaluate the efficacy and safety of maintenance and long-term treatment administration of upadacitinib, an orally administered Janus kinase 1 inhibitor, in adult participants with Crohn's Disease.

Study Overview

Status

Active, not recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

747

Phase

  • Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Argentina
      • Córdoba, Argentina, 5016
        • Hospital Privado Universitario - Hospital Privado Centro Medico de Cordoba S.A. /ID# 169229
    • Buenos Aires
      • Ciudad Autonoma Buenos Aires, Buenos Aires, Argentina, 1431
        • Cemic /Id# 169183
      • San Isidro, Buenos Aires, Argentina, 1642
        • Cardio Alem /ID# 211283
    • Buenos Aires F.D.
      • Ciudad Autonoma Buenos Aires, Buenos Aires F.D., Argentina, 1199
        • Hospital Italiano de Buenos Aires /ID# 215542
      • Ciudad Autonoma de Buenos Aire, Buenos Aires F.D., Argentina, 1115
        • Gedyt /ID# 210018
    • Santa Fe Province
      • Rosario, Santa Fe Province, Argentina, 2000
        • Hospital Provincial del Centenario /ID# 171251
  • Australia
    • New South Wales
      • Concord, New South Wales, Australia, 2139
        • Concord Repatriation General Hospital /ID# 171506
    • Queensland
      • North Mackay, Queensland, Australia, 4740
        • Coral Sea Clinical Research institute /ID# 212989
      • South Brisbane, Queensland, Australia, 4101
        • Mater Misericordiae Limited /ID# 204910
    • South Australia
      • Adelaide, South Australia, Australia, 5000
        • Royal Adelaide Hospital /ID# 171508
    • Victoria
      • Box Hill, Victoria, Australia, 3128
        • Box Hill Hospital /ID# 203735
    • Western Australia
      • Murdoch, Western Australia, Australia, 6150
        • Fiona Stanley Hospital /ID# 171507
  • Austria
      • Salzburg, Austria, 5020
        • Landeskrankenhaus Salzburg-Universitaetsklinikum der PMU (LKH) /ID# 214468
    • State of Vienna
      • Vienna, State of Vienna, Austria, 1030
        • Klinik Landstrasse /ID# 203438
      • Vienna, State of Vienna, Austria, 1090
        • Medizinische Universitaet Wien /ID# 169459
  • Belgium
      • Liège, Belgium, 4000
        • CHU de Liege /ID# 200294
    • Brussels Capital
      • Brussels, Brussels Capital, Belgium, 1200
        • Cliniques Universitaires UCL Saint-Luc /ID# 200293
    • Namur
      • Yvoir, Namur, Belgium, 5530
        • Universite Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant /ID# 200295
    • Oost-Vlaanderen
      • Ghent, Oost-Vlaanderen, Belgium, 9000
        • Duplicate_AZ Sint-Lucas /ID# 200296
    • Vlaams-Brabant
      • Leuven, Vlaams-Brabant, Belgium, 3000
        • Universitair Ziekenhuis Leuven /ID# 200031
  • Bosnia and Herzegovina
      • Sarajevo, Bosnia and Herzegovina, 71000
        • Clinical Center University of Sarajevo /ID# 201346
      • Sarajevo, Bosnia and Herzegovina, 71000
        • Polyclinic and Daily Hospital Dr. Al-Tawil /ID# 217843
    • Republika Srpska
      • Banja Luka, Republika Srpska, Bosnia and Herzegovina, 78000
        • Duplicate_University Clinical Centre of the Republic of Srpska /ID# 200743
    • Tuzlanski
      • Tuzla, Tuzlanski, Bosnia and Herzegovina, 75000
        • University Clinical Center Tuzla /ID# 210323
  • Brazil
    • Goiás
      • Goiânia, Goiás, Brazil, 74535-170
        • Instituto Goiano de Gastroenterologia e Endoscopia Digestiva /ID# 166853
    • La Spezia
      • Santo André, La Spezia, Brazil, 09060-870
        • Faculdade de Medicina do ABC /ID# 166854
    • Paraná
      • Curitiba, Paraná, Brazil, 80810-040
        • Hospital Nossa Senhora das Graças /ID# 166856
    • Rio Grande do Sul
      • Porto Alegre, Rio Grande do Sul, Brazil, 90035-903
        • Hospital de Clinicas de Porto Alegre /ID# 166855
    • São Paulo
      • Botucatu, São Paulo, Brazil, 18618-686
        • Upeclin Fmb - Unesp /Id# 166860
      • Ribeirão Preto, São Paulo, Brazil, 14049-900
        • Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto /ID# 166859
      • São José do Rio Preto, São Paulo, Brazil, 15015-110
        • Kaiser Clinica e Hospital Dia /ID# 166858
  • Bulgaria
      • Plovdiv, Bulgaria, 4001
        • Duplicate_UMHAT Kaspela EOOD /ID# 167615
      • Sofia, Bulgaria, 1202
        • Duplicate_Second MHAT Sofia /ID# 167616
      • Stara Zagora, Bulgaria, 6004
        • MHAT Trakia /ID# 201677
  • Canada
    • Alberta
      • Calgary, Alberta, Canada, T2N 4Z6
        • University of Calgary /ID# 166990
      • Edmonton, Alberta, Canada, T5R 1W2
        • Allen Whey Khye Lim Professional Corporation /ID# 168047
      • Edmonton, Alberta, Canada, T6K 4B2
        • Covenant Health /ID# 166996
      • Edmonton, Alberta, Canada, T6G 2B7
        • University of Alberta Hospital /ID# 166987
    • British Columbia
      • New Westminster, British Columbia, Canada, V3L 3W4
        • Fraser Clinical Trials Inc /ID# 166984
      • Vancouver, British Columbia, Canada, V5Z 2K5
        • Giri Gi Research Institute - Vancouver /ID# 166994
    • Nova Scotia
      • Halifax, Nova Scotia, Canada, B3H 2Y9
        • QEII - Health Sciences Centre /ID# 169308
    • Ontario
      • Greater Sudbury, Ontario, Canada, P3A 1W8
        • Medicor Research Inc /ID# 166997
      • London, Ontario, Canada, N6A 5W9
        • London Health Sciences Center- University Hospital /ID# 221039
      • North Bay, Ontario, Canada, P1B 2H3
        • Scott Shulman Medicine Professional Corporation /ID# 169065
      • Oshawa, Ontario, Canada, L1H 7K4
        • Taunton surgical centre /ID# 168045
      • Ottawa, Ontario, Canada, K1H 8L6
        • Ottawa Hospital Research Institute /ID# 212412
      • Vaughan, Ontario, Canada, L4L 4Y7
        • Toronto Digestive Disease Associates /ID# 166988
    • Quebec
      • Lévis, Quebec, Canada, G6V 3Z1
        • Hotel Dieu de Levis /ID# 166985
      • Montreal, Quebec, Canada, H2X 0A9
        • Centre Hospitalier de l'Universite de Montreal - CRCHUM /ID# 170122
      • Montreal, Quebec, Canada, H4A 3J1
        • Disc_Royal Victoria Hospital / McGill University Health Centre /ID# 170011
      • Sherbrooke, Quebec, Canada, J1G 2E8
        • CIUSSS de l'Estrie - CHUS /ID# 170936
  • Chile
      • Santiago, Chile, 7501504
        • Hospital Clinico Universidad De Los Andes /ID# 207463
      • Ñuñoa, Chile, 7750495
        • CEC SpA /ID# 169872
    • Bio-Bio
      • Concepción, Bio-Bio, Chile, 4070038
        • Hospital Guillermo Grant Benavente de Concepción /ID# 212421
    • Region Metropolitana Santiago
      • Providencia, Region Metropolitana Santiago, Chile, 7500571
        • CTR Estudios Clinicos /ID# 203940
    • Santiago Metropolitan
      • Santiago, Santiago Metropolitan, Chile, 2540364
        • Research Group /ID# 203178
  • China
      • Tianjin, China, 300052
        • Duplicate_Tianjin Med Univ General Hosp /ID# 206979
    • Beijing Municipality
      • Beijing, Beijing Municipality, China, 100032
        • Beijing Friendship Hospital /ID# 204175
    • Fujian
      • Xiamen, Fujian, China, 361004
        • Zhongshan Hospital Xiamen University /ID# 204986
    • Guangdong
      • Guangzhou, Guangdong, China, 510080
        • The First Affiliated Hospital, Sun Yat-sen University /ID# 205227
      • Guangzhou, Guangdong, China, 510515
        • Nanfang Hospital of Southern Medical University /ID# 204056
      • Guangzhou, Guangdong, China, 510655
        • The Sixth Affiliated Hospital of Sun Yat-sen University /ID# 204054
    • Hubei
      • Wuhan, Hubei, China, 430022
        • Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 204065
      • Wuhan, Hubei, China, 430030
        • Tongji Hospital Tongji Medical College of HUST /ID# 204051
    • Hunan
      • Changsha, Hunan, China, 410011
        • The Second Xiangya Hospital Of Central South University /ID# 204057
    • Jiangsu
      • Nanjing, Jiangsu, China, 210008
        • Nanjing Drum Tower Hospital /ID# 204899
    • Jiangxi
      • Nanchang, Jiangxi, China, 330006
        • The First Affiliated Hospital of Nanchang University /ID# 204052
    • Jilin
      • Changchun, Jilin, China, 130021
        • The First Hospital of Jilin University /ID# 206865
    • Shanghai Municipality
      • Shanghai, Shanghai Municipality, China, 200065
        • Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 204055
    • Zhejiang
      • Hangzhou, Zhejiang, China, 310009
        • The Second Affiliated Hospital of Zhejiang University School of Medicine /ID# 204058
      • Hangzhou, Zhejiang, China, 310018
        • Sir Run Run Shaw Hospital,Meical School Zhejiang University /ID# 204050
  • Colombia
    • Antioquia
      • Medellín, Antioquia, Colombia, 50034
        • Duplicate_Hospital Pablo Tobon Uribe /ID# 202403
      • Medellín, Antioquia, Colombia, 50034
        • Hospital San Vicente de Paul /ID# 200020
  • Croatia
      • Zadar, Croatia, 23000
        • Zadar General Hospital /ID# 205533
    • City of Zagreb
      • Zagreb, City of Zagreb, Croatia, 10000
        • Clinical Hospital Dubrava /ID# 171165
      • Zagreb, City of Zagreb, Croatia, 10000
        • Klinicki bolnicki centar Sestre milosrdnice /ID# 171194
      • Zagreb, City of Zagreb, Croatia, 10000
        • Klinicki bolnicki centar Zagreb /ID# 171168
      • Zagreb, City of Zagreb, Croatia, 10000
        • Poliklinika Solmed /ID# 211517
    • Split-Dalmatia County
      • Split, Split-Dalmatia County, Croatia, 21000
        • Klinicki Bolnicki Centar KBC Split /ID# 171205
  • Czechia
      • Hradec Králové, Czechia, 500 12
        • Hepato-Gastroenterologie HK, s.r.o. /ID# 171564
      • Ostrava, Czechia, 722 00
        • ARTROSCAN s.r.o. /ID# 171575
      • Prague, Czechia, 143 00
        • ResTrial s.r.o. /ID# 208651
      • České Budějovice, Czechia, 370 01
        • Nemocnice Ceske Budejovice a.s. /ID# 224390
  • Denmark
    • Capital Region
      • Herlev, Capital Region, Denmark, 2730
        • Herlev Hospital /ID# 200785
      • Hilleroed, Capital Region, Denmark, 3600
        • Nordsjaellands Hospital /ID# 200788
      • Hvidovre, Capital Region, Denmark, 2650
        • Kobenhavns Universitet - Hvidovre Hospital (HH) /ID# 200787
    • Region Sjælland
      • Roskilde, Region Sjælland, Denmark, 4000
        • Duplicate_Sjaellands Universitets Hospital /ID# 200786
  • Egypt
      • Alexandria, Egypt, 21131
        • Duplicate_Clinical Research Center, Faculty of Medicine, Alexandria university. /ID# 209561
      • Cairo, Egypt, 11559
        • National Hepatology and Tropical Medicine Research Institute /ID# 170991
      • Cairo, Egypt
        • Air Force Specialized Hospital /ID# 170993
      • Cairo, Egypt, 11566
        • Ain Shams University Faculty of Medicine /ID# 209566
    • Alexandria Governorate
      • Alexandria, Alexandria Governorate, Egypt, 21131
        • Alexandria University /ID# 171008
      • Alexandria, Alexandria Governorate, Egypt, 21131
        • Alexandria University /ID# 171017
    • Monufia Governorate
      • Menoufiya, Monufia Governorate, Egypt, 35111
        • National Liver Institute /ID# 170987
  • Estonia
      • Tartu, Estonia, 50406
        • Tartu University Hospital /ID# 203141
    • Harju
      • Tallinn, Harju, Estonia, 10617
        • West Tallinn Central Hospital /ID# 202787
  • France
      • Chambray-lès-Tours, France, 37170
        • CHRU Tours - Hopital Trousseau /ID# 169783
      • Créteil, France, 94000
        • Duplicate_CHU Henri Mondor /ID# 169782
      • Nantes, France, 44300
        • Clinique Jules Verne /ID# 222240
      • Nîmes, France, 30932
        • Polyclinique Grand Sud /ID# 170037
    • Alpes-Maritimes
      • Nice, Alpes-Maritimes, France, 06202
        • Chu de Nice-Hopital Larchet Ii /Id# 171004
    • Gironde
      • Pessac, Gironde, France, 33604
        • Duplicate_CHU Bordeaux - Hopital Haut Leveque /ID# 207812
    • Haute-Garonne
      • Toulouse, Haute-Garonne, France, 31400
        • CHU Toulouse - Hopital Rangueil /ID# 169784
    • Herault
      • Montpellier, Herault, France, 34295
        • Duplicate_Hopital Saint Eloi /ID# 170039
    • Isere
      • La Tronche, Isere, France, 38700
        • Duplicate_CHU Grenoble - Hopital Michallon /ID# 222403
    • Meurthe-et-Moselle
      • Vandœuvre-lès-Nancy, Meurthe-et-Moselle, France, 54500
        • Duplicate_CHRU Nancy - Hopitaux de Brabois /ID# 170970
    • Nord
      • Lille, Nord, France, 59037
        • CHRU Lille - Hopital Claude Huriez /ID# 206653
      • Valenciennes, Nord, France, 59300
        • CH Valenciennes /ID# 222399
    • Pays de la Loire Region
      • St-Priest-en-Jarez, Pays de la Loire Region, France, 42270
        • Centre Hospitalier Universitaire de Saint Etienne - Hopital Nord /ID# 171027
    • Rhone
      • Pierre-Bénite, Rhone, France, 69495
        • HCL - Hopital Lyon Sud /ID# 171030
    • Somme
      • Amiens, Somme, France, 80054
        • Duplicate_CHU Amiens-Picardie Site Sud /ID# 171023
    • Île-de-France Region
      • Clichy, Île-de-France Region, France, 92110
        • Hopital Beaujon /ID# 171007
  • Germany
      • Berlin, Germany, 12203
        • Charite Universitaetsklinikum Berlin - Campus Benjamin Franklin /ID# 169271
      • Berlin, Germany, 14163
        • Gastroenterologie am Mexikoplatz /ID# 203574
      • Essen, Germany, 45239
        • Universitaetsmedizin Essen St. Josef Krankenhaus Werden /ID# 203569
      • Halle, Germany, 06120
        • Universitaetsklinikum Halle (Saale) /ID# 207453
      • Münster, Germany, 48155
        • Medizinisches Versorgungszentrum Portal 10 /ID# 200212
    • Baden-Wurttemberg
      • Mannheim, Baden-Wurttemberg, Germany, 68167
        • Universitatsklinikum Mannheim /ID# 168754
      • Ulm, Baden-Wurttemberg, Germany, 89081
        • Universitaetsklinikum Ulm /ID# 203554
    • Bavaria
      • Erlangen, Bavaria, Germany, 91054
        • Universitaetsklinikum Erlangen /ID# 203550
    • Hesse
      • Frankfurt am Main, Hesse, Germany, 60431
        • Duplicate_Agaplesion Markus Krankenhaus /ID# 168753
      • Frankfurt am Main, Hesse, Germany, 60590
        • Universitaetsklinikum Frankfurt /ID# 203567
    • Saarland
      • Saarbrücken, Saarland, Germany, 66111
        • Zentrum für Gastroenterologie Saar MVZ GmbH /ID# 206739
    • Schleswig-Holstein
      • Kiel, Schleswig-Holstein, Germany, 24105
        • Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 168755
  • Greece
      • Athens, Greece, 10676
        • General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 167033
      • Thessaloniki, Greece, 54642
        • General Hospital of Thessaloniki Hippokrateio /ID# 208823
    • Attica
      • Athens, Attica, Greece, 11527
        • General Hospital of Athens Ippokratio /ID# 167032
      • Athens, Attica, Greece, 11527
        • General Hospital of Chest Diseases of Athens SOTIRIA /ID# 202102
      • Piraeus, Attica, Greece, 18536
        • Tzaneio general hospital of Piraeus /ID# 206435
    • Crete
      • Heraklion, Crete, Greece, 71500
        • University General Hospital of Heraklion PA.G.N.I /ID# 167031
  • Hong Kong
      • Hong Kong, Hong Kong, 999077
        • Queen Mary Hospital /ID# 171214
      • Hong Kong, Hong Kong
        • Tuen Mun Hospital /ID# 171213
  • Hungary
      • Budapest, Hungary, 1134
        • Magyar Honvedseg Egeszsegugyi Kozpont /ID# 200888
      • Budapest, Hungary, 1036
        • Obudai Egeszsegugyi Centrum /ID# 201886
      • Budapest, Hungary, 1085
        • Duplicate_Semmelweis Egyetem /ID# 210166
      • Debrecen, Hungary, 4031
        • Debreceni Egyetem Kenezy Gyula Egyetemi Korhaz /ID# 200887
      • Székesfehérvár, Hungary, 8000
        • Mentahaz Maganorvosi Kozpont /ID# 201888
    • Baranya
      • Mohács, Baranya, Hungary, 7700
        • Pecsi Tudomanyegyetem Klinikai Kozpont Mohacsi Korhaz /ID# 209440
    • Borsod-Abauj Zemplen county
      • Encs, Borsod-Abauj Zemplen county, Hungary, 3860
        • CRU Hungary Egeszsegugyi és Szolgaltato Kft. /ID# 205549
    • Hajdú-Bihar
      • Debrecen, Hajdú-Bihar, Hungary, 4032
        • Duplicate_Debreceni Egyetem Klinikai Kozpont /ID# 216420
    • Heves County
      • Gyöngyös, Heves County, Hungary, 3200
        • Gyongyosi Bugat Pal Korhaz /ID# 201885
    • Komárom-Esztergom
      • Tatabánya, Komárom-Esztergom, Hungary, 2800
        • Komarom-Esztergom Varmegyei Szent Borbala Korhaz (Clinexpert Tatabanya Kft.) /ID# 209896
    • Pest County
      • Kistarcsa, Pest County, Hungary, 2143
        • Kistarcsai Flor Ferenc Korhaz /ID# 206153
  • Ireland
      • Cork, Ireland, T12 WE28
        • Mercy University Hospital /ID# 206512
  • Israel
      • Petah Tikva, Israel, 4941492
        • Rabin Medical Center. /ID# 202634
    • Central District
      • Rehovot, Central District, Israel, 7661041
        • Duplicate_Kaplan Medical Center /ID# 170275
      • Ẕerifin, Central District, Israel, 70300
        • Yitzhak Shamir Medical Center /ID# 206449
    • Jerusalem
      • Jerusalem, Jerusalem, Israel, 91120
        • Hadassah Medical Center-Hebrew University /ID# 169926
    • Southern District
      • Ashkelon, Southern District, Israel, 7830604
        • Barzilai Medical Center /ID# 223374
      • Beersheba, Southern District, Israel, 8443901
        • Soroka University Medical Center /ID# 169911
    • Tel Aviv
      • Tel Aviv, Tel Aviv, Israel, 6423906
        • Tel Aviv Sourasky Medical Center /ID# 206450
  • Italy
      • Catania, Italy, 95126
        • Ospedale Cannizzaro /ID# 168161
      • Catanzaro, Italy, 88100
        • Azienda Ospedaliero-Universitaria Renato Dulbecco /ID# 201986
      • Genova, Italy, 16132
        • Policlinico San Martino/Univer /ID# 168162
      • Modena, Italy, 41124
        • Azienda Ospedaliero-Universitaria di Modena /ID# 200009
      • Palermo, Italy, 90146
        • Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello /ID# 168157
      • Pisa, Italy, 56125
        • Duplicate_Azienda Ospedaliero Universitaria Pisana-Stabilimento di Cisanello /ID# 202419
      • Roma, Italy, 00128
        • Fondazione Policlinico Universitario Campus Bio-Medico /ID# 168151
    • Emilia-Romagna
      • Bologna, Emilia-Romagna, Italy, 40138
        • Duplicate_IRCCS AOU di Bologna - Policlinico Sant'Orsola-Malpighi /ID# 168155
    • Lombardy
      • Rozzano, Lombardy, Italy, 20089
        • IRCCS Istituto Clinico Humanitas /ID# 168153
    • Milano
      • Milan, Milano, Italy, 20162
        • ASST Grande Ospedale Metropolitano Niguarda /ID# 170906
      • Milan, Milano, Italy, 20122
        • ASST Fatebenefratelli Sacco - Ospedale Fatebenefratelli e Oftalmico /ID# 168149
    • Roma
      • Rome, Roma, Italy, 00133
        • Azienda Ospedaliera Universitaria Policlinico Tor Vergata /ID# 168156
      • Rome, Roma, Italy, 00152
        • Duplicate_Azienda Ospedaliera San Camillo Forlanini /ID# 168152
      • Rome, Roma, Italy, 00168
        • Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Universita Cattolica /ID# 168150
    • Verona
      • Negrar, Verona, Italy, 37024
        • Duplicate_IRCCS Ospedale Sacro Cuore Don Calabria /ID# 168154
  • Japan
    • Aichi-ken
      • Nagakute, Aichi-ken, Japan, 480-1195
        • Aichi Medical University Hospital /ID# 165989
      • Nagoya, Aichi-ken, Japan, 466-8560
        • Nagoya University Hospital /ID# 165987
      • Nagoya, Aichi-ken, Japan, 467-8602
        • Nagoya City University Hospital /ID# 165988
      • Toyohashi, Aichi-ken, Japan, 441-8570
        • Toyohashi Municipal Hospital /ID# 200176
    • Aomori
      • Hirosaki-shi, Aomori, Japan, 036-8545
        • National Hospital Organization Hirosaki General Medical Center /ID# 165976
    • Chiba
      • Sakura-shi, Chiba, Japan, 285-8741
        • Toho University Sakura Medical Center /ID# 165978
    • Fukuoka
      • Chikushino-shi, Fukuoka, Japan, 818-8502
        • Fukuoka University Chikushi Hospital /ID# 214402
      • Kurume-shi, Fukuoka, Japan, 830-0011
        • Kurume University Hospital /ID# 165996
    • Gunma
      • Takasaki-shi, Gunma, Japan, 370-0829
        • National Hospital Organization Takasaki General Medical Center /ID# 167151
    • Hiroshima
      • Fukuyama-shi, Hiroshima, Japan, 720-8520
        • Duplicate_NHO Fukuyama Medical Center /ID# 167155
      • Hiroshima, Hiroshima, Japan, 734-8551
        • Hiroshima University Hospital /ID# 165998
    • Hokkaido
      • Asahikawa-shi, Hokkaido, Japan, 078-8510
        • Duplicate_Asahikawa Medical University Hospital /ID# 167148
      • Sapporo, Hokkaido, Japan, 060-0033
        • Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 165975
      • Sapporo, Hokkaido, Japan, 060-8543
        • Duplicate_Sapporo Medical University Hospital /ID# 167152
      • Sapporo, Hokkaido, Japan, 064-0919
        • Sapporo IBD Clinic /ID# 223559
    • Hyōgo
      • Kobe, Hyōgo, Japan, 650-0015
        • Aoyama Clinic /ID# 165993
      • Nishinomiya-shi, Hyōgo, Japan, 663-8501
        • Duplicate_Hyogo Medical University Hospital /ID# 165991
    • Ishikawa-ken
      • Kanazawa, Ishikawa-ken, Japan, 920-8641
        • Kanazawa University Hospital /ID# 169212
    • Iwate
      • Morioka, Iwate, Japan, 020-8505
        • Iwate Medical University Uchimaru Medical Center /ID# 202465
    • Kagoshima-ken
      • Kagoshima, Kagoshima-ken, Japan, 890-0064
        • Imamura General Hospital /ID# 227135
      • Kagoshima, Kagoshima-ken, Japan, 892-0824
        • Idzuro Imamura Hospital /ID# 206655
      • Kagoshima, Kagoshima-ken, Japan, 892-0846
        • Sameshima Hospital /ID# 206677
    • Kanagawa
      • Yokohama, Kanagawa, Japan, 232-0024
        • Duplicate_Yokohama City University Medical Center /ID# 167156
    • Kyoto
      • Kyoto, Kyoto, Japan, 605-0981
        • Japanese Red Cross Kyoto Daiichi Hosital /ID# 165990
      • Kyoto, Kyoto, Japan, 606-8507
        • Duplicate_Kyoto University Hospital /ID# 169887
    • Mie-ken
      • Yokkaichi-shi, Mie-ken, Japan, 510-0016
        • Yokkaichi Hazu Medical Center /ID# 167201
    • Miyagi
      • Sendai, Miyagi, Japan, 9808574
        • Tohoku University Hospital /ID# 167150
    • Nara
      • Kashihara-shi, Nara, Japan, 634-8522
        • Nara Medical University Hospital /ID# 169213
      • Yamatotakada-shi, Nara, Japan, 635-0022
        • Kenseikai Dongo Hospital /ID# 208105
    • Niigata
      • Niigata, Niigata, Japan, 951-8520
        • Duplicate_Niigata University Medical & Dental Hospital /ID# 170042
    • Oita Prefecture
      • Ōita, Oita Prefecture, Japan, 870-0823
        • Ishida Clinic of IBD and Gastroenterology /ID# 167149
    • Okayama-ken
      • Kurashiki-shi, Okayama-ken, Japan, 710-0142
        • Chikuba Hospital for Proctological and Gastrointestinal Diseases /ID# 165994
      • Okayama, Okayama-ken, Japan, 700-8558
        • Duplicate_Okayama University Hospital /ID# 167354
    • Osaka
      • Osaka, Osaka, Japan, 530-0011
        • Kinshukai Infusion Clinic /ID# 218873
      • Osaka, Osaka, Japan, 545-8586
        • Osaka Metropolitan University Hospital /ID# 165999
      • Suita-shi, Osaka, Japan, 565-0871
        • Duplicate_Osaka University Hospital /ID# 169661
      • Takatsuki-shi, Osaka, Japan, 569-8686
        • Osaka Medical and Pharmaceutical University Hospital /ID# 206323
    • Saitama
      • Saitama-shi, Saitama, Japan, 336-0963
        • Tokitokai Tokito clinic /ID# 165977
    • Shiga
      • Ōtsu, Shiga, Japan, 520-2192
        • Duplicate_Shiga University of Medical Science Hospital /ID# 167157
    • Shizuoka
      • Hamamatsu, Shizuoka, Japan, 431-3192
        • Duplicate_Hamamatsu University Hospital /ID# 224402
      • Sunto-gun, Shizuoka, Japan, 411-8611
        • Duplicate_NHO Shizuoka Medical Center /ID# 167153
    • Tokyo
      • Bunkyo-ku, Tokyo, Japan, 113-8519
        • Institute of Science Tokyo Hospital /ID# 165982
      • Hachioji-shi, Tokyo, Japan, 192-0032
        • Tokai University Hachioji Hospital /ID# 165984
      • Minato-ku, Tokyo, Japan, 105-8471
        • Duplicate_The Jikei University Hospital /ID# 167154
      • Mitaka-shi, Tokyo, Japan, 181-8611
        • Kyorin University Hospital /ID# 165983
      • Shinjuku-ku, Tokyo, Japan, 162-8666
        • Duplicate_Tokyo Women's Medical University Hospital /ID# 205979
    • Toyama
      • Toyama, Toyama, Japan, 930-8550
        • Toyama Prefectural Central Hospital /ID# 217836
    • Wakayama
      • Wakayama, Wakayama, Japan, 640-8558
        • Japanese Red Cross Wakayama Medical Center /ID# 200641
      • Wakayama, Wakayama, Japan, 641-8510
        • Wakayama Medical University Hospital /ID# 169480
    • Yamagata
      • Yamagata, Yamagata, Japan, 990-9585
        • Yamagata University Hospital /ID# 200158
  • Latvia
      • Riga, Latvia, 1035
        • VCA Polyclinic Aura /ID# 169499
      • Riga, Latvia, LV-1079
        • Duplicate_Digestive Disease Center Gastro /ID# 169518
      • Riga, Latvia, LV-1002
        • Pauls Stradins Clinical University Hospital /ID# 169494
  • Lithuania
      • Kaunas, Lithuania, 50161
        • Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 207030
      • Vilnius, Lithuania, 08661
        • Vilnius University Hospital Santaros Klinikos /ID# 203269
  • Malaysia
    • Kedah
      • Alor Star, Kedah, Malaysia, 05460
        • Duplicate_Hospital Sultanah Bahiyah /ID# 201317
    • Kelantan
      • Kelantan, Kelantan, Malaysia, 16150
        • Universiti Sains Malaysia /ID# 200101
    • Selangor
      • Kuala Lumpur, Selangor, Malaysia, 56000
        • Universiti Kebangsaan Malaysia (UKM) Medical Centre /ID# 170780
  • Mexico
    • Durango
      • Durango, Durango, Mexico, 34000
        • Instituto de Investigaciones Aplicadas a la Neurociencias A.C. /ID# 207681
    • Guanajuato
      • León, Guanajuato, Mexico, 37000
        • Morales Vargas Centro de Investigacion S.C. /ID# 203496
    • Jalisco
      • Guadalajara, Jalisco, Mexico, 44650
        • Clinica de Investigacion en Reumatologia y Obesidad S.C. /ID# 206843
  • Netherlands
    • Gelderland
      • Nijmegen, Gelderland, Netherlands, 6525 GA
        • Radboud Universitair Medisch Centrum /ID# 166931
    • Limburg
      • Heerlen, Limburg, Netherlands, 6419 PC
        • Zuyderland Medisch Centrum /ID# 169699
    • North Holland
      • Amsterdam, North Holland, Netherlands, 1081 HV
        • Amsterdam UMC, Location VUmc /ID# 166930
      • Amsterdam, North Holland, Netherlands, 1091 AC
        • Olvg /Id# 166932
    • Overijssel
      • Enschede, Overijssel, Netherlands, 7512 KZ
        • Medisch Spectrum Twente /ID# 170299
  • Poland
    • Lesser Poland Voivodeship
      • Krakow, Lesser Poland Voivodeship, Poland, 30-149
        • Malopolskie Centrum Kliniczne /ID# 202169
    • Lower Silesian Voivodeship
      • Wroclaw, Lower Silesian Voivodeship, Poland, 53-149
        • Vistamed /ID# 208571
    • Masovian Voivodeship
      • Warsaw, Masovian Voivodeship, Poland, 00-189
        • Centrum Zdrowia MDM /ID# 200493
      • Warsaw, Masovian Voivodeship, Poland, 00-728
        • Duplicate_WIP Warsaw IBD Point Profesor Kierkus /ID# 224302
      • Warsaw, Masovian Voivodeship, Poland, 02-665
        • Centrum Medyczne Reuma Park /ID# 200489
  • Portugal
      • Porto, Portugal, 4200-319
        • Unidade Local de Saude Sao Joao, EPE /ID# 170211
    • Braga District
      • Guimarães, Braga District, Portugal, 4835-044
        • Duplicate_Hospital da Senhora da Oliveira Guimaraes, EPE /ID# 170204
    • Porto District
      • Lisbon, Porto District, Portugal, 1349-019
        • Hospital Egas Moniz /ID# 170232
    • Setúbal District
      • Almada, Setúbal District, Portugal, 2805-267
        • Duplicate_Hospital Garcia de Orta, EPE /ID# 170209
    • Viana do Castelo District
      • Ponte de Lima, Viana do Castelo District, Portugal, 4990-041
        • Unidade Local de Saúde do Alto Minho, EPE - Hospital Conde de Bertiandos /ID# 200608
  • Puerto Rico
      • San Juan, Puerto Rico, 00918-3756
        • Mindful Medical Research /ID# 203356
      • San Juan, Puerto Rico, 00935
        • School of Medicine University of Puerto Rico-Medical Science Campus /ID# 166769
  • Romania
      • Timișoara, Romania, 300002
        • Cabinet Particular Policlinic Algomed /ID# 167832
    • București
      • Bucharest, București, Romania, 022328
        • Fundeni Clinical Institute /ID# 167831
    • Cluj
      • Cluj-Napoca, Cluj, Romania, 400380
        • Duplicate_Clinica GASTRO MED SRL /ID# 206363
  • Russia
      • Moscow, Russia, 105554
        • Olla-Med Clinic /ID# 208723
      • Murmansk, Russia, 183047
        • P.A. Bayandin Murmansk Regiona /ID# 169590
      • Pushkin, Russia, 196603
        • Euromedservice /ID# 206608
      • Saint Petersburg, Russia, 194156
        • X7 Clinical Research Center /ID# 216348
      • Saint Petersburg, Russia, 197110
        • City Clinical Hospital No. 31 /ID# 208871
    • Kaliningrad Oblast
      • Kaliningrad, Kaliningrad Oblast, Russia, 236016
        • Immanuel Kant Baltic Federal University /ID# 203810
    • Murmansk Oblast
      • Petrozavodsk, Murmansk Oblast, Russia, 185019
        • Republican hospital named after V.A. Baranov /ID# 206497
    • Novosibirsk Oblast
      • Novosibirsk, Novosibirsk Oblast, Russia, 630099
        • LLC Medical Center /ID# 209234
    • Permskiy Kray
      • Perm, Permskiy Kray, Russia, 614109
        • Perm Clinical Center of the Federal Medical and Biological Agency /ID# 202989
    • Stavropol Kray
      • Pyatigorsk, Stavropol Kray, Russia, 357500
        • LLC Novaya Klinika /ID# 206613
      • Stavropol, Stavropol Kray, Russia, 355012
        • Professor Pasechnikov Gastroenterology and Pankreatology clinic /ID# 202996
    • Tatarstan, Respublika
      • Kazan', Tatarstan, Respublika, Russia, 420012
        • Kazan State Medical University /ID# 169589
  • Serbia
    • Beograd
      • Belgrade, Beograd, Serbia, 11000
        • Clinical Hosp Center Zvezdara /ID# 168216
      • Belgrade, Beograd, Serbia, 11000
        • Military Medical Academy /ID# 168785
      • Belgrade, Beograd, Serbia, 11000
        • University Clinical Center Serbia /ID# 168217
      • Belgrade, Beograd, Serbia, 11080
        • Clin Hosp Ctr Bezanijska Kosa /ID# 168787
    • Sumadijski Okrug
      • Kragujevac, Sumadijski Okrug, Serbia, 34000
        • Duplicate_University Clinical Center Kragujevac /ID# 205856
    • Vojvodina
      • Novi Sad, Vojvodina, Serbia, 21000
        • Duplicate_Clinical Center Vojvodina /ID# 168196
  • Singapore
      • Singapore, Singapore, 258499
        • Gleneagles Medical Centre /ID# 206019
      • Singapore, Singapore, 308433
        • Tan Tock Seng Hospital /ID# 203158
    • Central Singapore
      • Singapore, Central Singapore, Singapore, 228510
        • Duplicate_KL Ling Gastroenterology and Liver Clinic /ID# 205739
  • Slovakia
    • Banská Bystrica Region
      • Banská Bystrica, Banská Bystrica Region, Slovakia, 975 17
        • Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 169960
    • Nitra Region
      • Nitra, Nitra Region, Slovakia, 949 01
        • KM Management, spol. s.r.o. /ID# 170202
  • Slovenia
      • Ljubljana, Slovenia, 1000
        • Univ Medical Ctr Ljubljana /ID# 211041
  • South Africa
    • Free State
      • Bloemfontein, Free State, South Africa, 9301
        • Farmovs (Pty) Ltd /Id# 207534
    • Gauteng
      • Johannesburg, Gauteng, South Africa, 1820
        • Lenasia Clinical Trial Centre /ID# 205143
      • Johannesburg, Gauteng, South Africa, 1864
        • Wits Clinical Research /ID# 170850
    • Western Cape
      • Cape Town, Western Cape, South Africa, 7700
        • Allergy & Immunology (AIU) /ID# 171427
      • Cape Town, Western Cape, South Africa, 7708
        • Dr JP Wright /ID# 170882
      • Cape Town, Western Cape, South Africa, 7800
        • Private Practice Dr MN Rajabally /ID# 169851
  • South Korea
      • Seoul, South Korea, 03722
        • Yonsei University Health System Severance Hospital /ID# 167567
    • Busan Gwang Yeogsi
      • Busan, Busan Gwang Yeogsi, South Korea, 48108
        • Inje University Haeundae Hospital /ID# 202631
      • Busan, Busan Gwang Yeogsi, South Korea, 49201
        • Dong-A University Medical Center /ID# 167568
      • Busan, Busan Gwang Yeogsi, South Korea, 49241
        • Duplicate_Pusan National University Hospital /ID# 167565
    • Daegu Gwang Yeogsi
      • Daegu, Daegu Gwang Yeogsi, South Korea, 41944
        • Kyungpook National University Hospital /ID# 207020
    • Gyeonggido
      • Guri-si, Gyeonggido, South Korea, 11923
        • Duplicate_Hanyang University Gurihospital /ID# 167563
      • Seongnam-si, Gyeonggido, South Korea, 13496
        • Duplicate_CHA University Bundang Medical Center /ID# 167569
    • Seoul Teugbyeolsi
      • Dongjak-gu, Seoul Teugbyeolsi, South Korea, 06973
        • Chungang University Hospital /ID# 207021
      • Seoul, Seoul Teugbyeolsi, South Korea, 03181
        • Kangbuk Samsung Hospital /ID# 167562
      • Seoul, Seoul Teugbyeolsi, South Korea, 06351
        • Samsung Medical Center /ID# 167564
  • Spain
      • A Coruña, Spain, 15006
        • Duplicate_Hospital Universitario A Coruna - CHUAC /ID# 203909
      • Barcelona, Spain, 08036
        • Hospital Clinic de Barcelona /ID# 202726
      • Barcelona, Spain, 08035
        • Hospital Universitario Vall de Hebron /ID# 202721
      • Girona, Spain, 17007
        • Hospital Universitario de Girona Doctor Josep Trueta /ID# 202644
      • Huelva, Spain, 21005
        • Hospital Juan Ramon Jimenez /ID# 202727
      • Madrid, Spain, 28046
        • Hospital Universitario La Paz /ID# 202725
      • Salamanca, Spain, 37711
        • Hospital Universitario de Salamanca /ID# 206359
      • Seville, Spain, 41009
        • Hospital Universitario Virgen Macarena /ID# 202722
      • Valencia, Spain, 46010
        • Hospital Clinico Universitario de Valencia /ID# 209658
      • Valencia, Spain, 46026
        • Hospital Universitario y Politecnico La Fe /ID# 202720
    • Balearic Islands
      • Palma de Mallorca, Balearic Islands, Spain, 07120
        • Hospital Universitari Son Espases /ID# 201969
    • Cantabria
      • Santander, Cantabria, Spain, 39008
        • Hospital Universitario Marques de Valdecilla /ID# 202495
    • Las Palmas
      • Las Palmas de Gran Canaria, Las Palmas, Spain, 35019
        • Hospital Universitario Dr. Negrin /ID# 202723
    • Navarre
      • Pamplona, Navarre, Spain, 31008
        • Hospital Universitario de Navarra /ID# 202354
  • Sweden
    • Halland County
      • Halmstad, Halland County, Sweden, 302 33
        • Hallands Hospital Halmstad /ID# 170815
    • Stockholm County
      • Solna, Stockholm County, Sweden, 171 64
        • Karolinska University Hospital Solna /ID# 224489
    • Västra Götaland County
      • Alingsås, Västra Götaland County, Sweden, 441 33
        • Alingsas lasarett /ID# 170814
      • Borås, Västra Götaland County, Sweden, 501 82
        • Sodra Alvsborgs sjukhus /ID# 203078
      • Gothenburg, Västra Götaland County, Sweden, 413 46
        • Duplicate_Sahlgrenska University Hospital /ID# 169032
      • Gothenburg, Västra Götaland County, Sweden, 413 46
        • Duplicate_Sahlgrenska University Hospital /ID# 169170
  • Switzerland
      • Bern, Switzerland, 3010
        • Inselspital, Universitaetsspital Bern /ID# 170994
    • Canton of Zurich
      • Zurich, Canton of Zurich, Switzerland, 8091
        • Duplicate_Universitatsspital Zurich /ID# 171000
  • Taiwan
      • Taichung, Taiwan, 40705
        • Taichung Veterans General Hospital /ID# 169802
      • Taichung, Taiwan, 40447
        • China Medical University Hospital /ID# 169803
      • Taoyuan, Taiwan, 333
        • Linkou Chang Gung Memorial Hospital /ID# 169804
    • Taipei
      • Taipei City, Taipei, Taiwan, 100
        • National Taiwan University Hospital /ID# 169805
  • Turkey (Türkiye)
      • Ankara, Turkey (Türkiye), 06590
        • Ankara Univ Medical Faculty /ID# 206408
      • Battalgazi/malatya, Turkey (Türkiye), 44280
        • Inonu Universitesi Turgut Ozal /ID# 201266
      • Hatay, Turkey (Türkiye), 31001
        • Mustafa Kemal University Medic /ID# 171328
      • Istanbul, Turkey (Türkiye), 34093
        • Duplicate_Istanbul University Istanbul Medical Faculty /ID# 171365
      • Istanbul, Turkey (Türkiye), 34899
        • Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi /ID# 171326
      • Mersin, Turkey (Türkiye), 33343
        • Mersin University Medical /ID# 171330
    • Ankara
      • Yenimahalle, Ankara, Turkey (Türkiye), 06560
        • Gazi Universitesi Tip Fakultes /ID# 217445
    • Istanbul
      • Kadıköy, Istanbul, Turkey (Türkiye), 34742
        • Acibadem Kozyatagi Hospital /ID# 209404
      • Şişli, Istanbul, Turkey (Türkiye), 34371
        • Sisli Etfal Train & Res Hosp /ID# 171327
    • Kayseri
      • Melikgazi, Kayseri, Turkey (Türkiye), 38030
        • Duplicate_Erciyes University Medical Fac /ID# 171325
  • Ukraine
      • Kharkiv, Ukraine, 61037
        • Kharkiv City Clinical Hospital No.2 n.a. Prof. O.O. Shalimov /ID# 167918
      • Kyiv, Ukraine, 01030
        • Kyiv City Clinical Hospital No.18 /ID# 207890
      • Kyiv, Ukraine, 01030
        • Medical Centre of "Ukrainian German Antiulcer Gastroenterology Centre BYK-KYIV" /ID# 203739
      • Kyiv, Ukraine, 04106
        • MNE KRC Kyiv Regional Clinical Hospital /ID# 202456
    • Lviv Oblast
      • Lviv, Lviv Oblast, Ukraine, 79000
        • Lviv Railway Clinical Hospital of branch Healthcare Centers of Public Joint Stoc /ID# 167917
    • Vinnytsia Oblast
      • Vinnytsia, Vinnytsia Oblast, Ukraine, 21018
        • MNE Vinnytsia Regional Clinical Hospital n.a. M.I.Pyrogov /ID# 222111
  • United Kingdom
      • Belfast, United Kingdom, BT16 1RH
        • Ulster Hospital - South Eastern Health & Social Care Trust /ID# 205324
      • Birmingham, United Kingdom, B15 2TH
        • University Hospitals Birmingham NHS Foundation Trust /ID# 169058
      • Dudley, United Kingdom, DY1 2HQ
        • The Dudley Group NHS Foundation Trust /ID# 169057
      • Harrow, United Kingdom, HA1 3UJ
        • London North West University Healthcare NHS Trust /ID# 169056
      • Newcastle upon Tyne, United Kingdom, NE3 3HD
        • The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 169063
      • Stockport, United Kingdom, SK2 7JE
        • Duplicate_Stockport NHS foundation trust /ID# 208717
      • Wolverhampton, United Kingdom, WV10 0QP
        • The Royal Wolverhampton NHS Trust /ID# 171395
    • Bath And North East Somerset
      • Bath, Bath And North East Somerset, United Kingdom, BA1 3NG
        • Duplicate_Royal United Hospitals Bath /ID# 169062
    • Cheshire West And Chester
      • Warrington, Cheshire West And Chester, United Kingdom, WA5 1QG
        • Warrington and Halton Hospitals NHS Foundation Trust /ID# 171396
    • Greater London
      • London, Greater London, United Kingdom, E1 2ES
        • Disc_Barts Health NHS Trust - The Royal London Hospital /ID# 218830
      • London, Greater London, United Kingdom, SE5 9RS
        • Kings College Hospital NHS Foundation Trust /ID# 169060
      • London, Greater London, United Kingdom, SW17 0QT
        • St George University Hospitals NHS Foundation Trust /ID# 205550
    • Somerset
      • Taunton, Somerset, United Kingdom, TA1 5DA
        • Taunton and Somerset NHS Foundation Trust /ID# 209666
    • Warrington
      • Prescot, Warrington, United Kingdom, L35 5DR
        • Mersey and West Lancashire NHS teaching hospitals trust /ID# 209087
  • United States
    • Alabama
      • Mobile, Alabama, United States, 36606
        • East View Medical Research, LLC /ID# 171132
      • Mobile, Alabama, United States, 36608
        • CB Flock Research Corporation /ID# 166239
    • Arizona
      • Chandler, Arizona, United States, 85224
        • Delsol Research Management, Ll /Id# 170164
      • Scottsdale, Arizona, United States, 85258
        • Duplicate_HonorHealth Research Institute - Shea /ID# 164725
      • Sun City, Arizona, United States, 85306
        • Duplicate_Arizona Arthritis & Rheumatology Research, PLLC /ID# 164702
    • California
      • Coronado, California, United States, 92118-1408
        • Southern California Res. Ctr. /ID# 169653
      • Covina, California, United States, 91722-3797
        • Citrus Valley Gastroenterology /ID# 166230
      • Irvine, California, United States, 92618
        • Hoag Memorial Hosp Presbyterian /ID# 222538
      • La Jolla, California, United States, 92037
        • UC San Diego Health System /ID# 164763
      • Los Alamitos, California, United States, 90720-3309
        • United Medical Doctors /ID# 207458
      • Los Angeles, California, United States, 90067-2001
        • Gastrointestinal Biosciences Clinical Trials, LLC /ID# 164640
      • Mission Hills, California, United States, 91345
        • Facey Medical Foundation /ID# 203138
      • Murrieta, California, United States, 92563
        • United Medical Doctors - Murrieta /ID# 164602
      • San Diego, California, United States, 92123
        • Medical Assoc Research Grp /ID# 169704
      • San Francisco, California, United States, 94158
        • Univ of California San Francis /ID# 164653
      • San Francisco, California, United States, 94115
        • UCSF Medical Center - Mount Zion /ID# 202372
      • San Pablo, California, United States, 94806
        • Care Access Research /ID# 167765
    • Colorado
      • Colorado Springs, Colorado, United States, 80907
        • Peak Gastroenterology Associates, PC /ID# 170166
      • Colorado Springs, Colorado, United States, 80918
        • Delta Waves, Inc. /ID# 164656
      • Wheat Ridge, Colorado, United States, 80033-2896
        • Western States Clinical Res /ID# 164625
    • Connecticut
      • Hamden, Connecticut, United States, 06518
        • Gastroenterology Center of Connecticut /ID# 164614
    • Florida
      • Coral Springs, Florida, United States, 33067-3173
        • Advanced Research - Coral Springs /ID# 218019
      • Jacksonville, Florida, United States, 32256
        • Encore Borland-Groover Clinical Research /Id# 203500
      • Maitland, Florida, United States, 32751-6108
        • Ctr for Advanced Gastroenterol /ID# 165306
      • Miami, Florida, United States, 33165
        • Crystal Pharmacology Research /ID# 166118
      • Miami, Florida, United States, 33186-4643
        • Coral Research Clinic /ID# 164604
      • New Port Richey, Florida, United States, 34653
        • Advanced Research Institute, Inc /ID# 164601
      • Orlando, Florida, United States, 32803
        • Endoscopic Research, Inc. /ID# 206139
      • Orlando, Florida, United States, 32808
        • Omega Research Group /ID# 203482
      • Tampa, Florida, United States, 33607
        • Clinical Research Trials of Florida, Inc. /ID# 203486
      • Tampa, Florida, United States, 33613-4680
        • Duplicate_AdventHealth Tampa /ID# 171181
      • Tampa, Florida, United States, 33606-1246
        • Duplicate_Clinical Research of West Florida, Inc /ID# 205828
      • Tampa, Florida, United States, 33606-1246
        • Duplicate_Clinical Research of West Florida, Inc /ID# 208119
    • Georgia
      • Macon, Georgia, United States, 31201
        • Gastroenterology Associates of Central Georgia, LLC /ID# 165492
      • Roswell, Georgia, United States, 30076-4913
        • Gastroenterology Consultants, P.C /ID# 218218
      • Suwanee, Georgia, United States, 30024
        • Atlanta Gastroenterology Spec /ID# 164698
    • Idaho
      • Boise, Idaho, United States, 83706
        • Treasure Valley Medical Research /ID# 215030
    • Illinois
      • Chicago, Illinois, United States, 60612
        • Duplicate_Rush University Medical Center /ID# 165470
      • Chicago, Illinois, United States, 60637-1426
        • Duplicate_University of Chicago Medicine /ID# 165509
      • Downers Grove, Illinois, United States, 60515-5509
        • DuPage Medical Group /ID# 205320
    • Indiana
      • Evansville, Indiana, United States, 47714-8011
        • MediSphere Medical Research Center /ID# 166233
      • Indianapolis, Indiana, United States, 46237
        • Indianapolis Gastroenterology /ID# 164649
      • New Albany, Indiana, United States, 47150-4053
        • Aquiant Research /ID# 205505
    • Iowa
      • Iowa City, Iowa, United States, 52242
        • University of Iowa Hospitals and Clinics /ID# 165405
    • Kentucky
      • Crestview Hills, Kentucky, United States, 41017
        • Tri-State Gastroenterology /ID# 165469
      • Louisville, Kentucky, United States, 40202
        • Duplicate_University of Louisville /ID# 165391
      • Louisville, Kentucky, United States, 40202
        • University of Louisville Hospital /ID# 168520
    • Louisiana
      • Houma, Louisiana, United States, 70360
        • Houma Digestive Health Special /ID# 164727
      • New Orleans, Louisiana, United States, 70115
        • Nola Research Works, LLC /ID# 164612
      • Shreveport, Louisiana, United States, 71105-6800
        • Louisiana Research Center, LLC /ID# 164694
    • Maryland
      • Baltimore, Maryland, United States, 21287-0010
        • Duplicate_Johns Hopkins University School of Medicine /ID# 211939
      • Chevy Chase, Maryland, United States, 20815
        • Metropolitan Gastroenterology Group - Chevy Chase /ID# 164647
      • Columbia, Maryland, United States, 21045
        • Gastro Center of Maryland /ID# 171180
    • Massachusetts
      • Burlington, Massachusetts, United States, 01805
        • Duplicate_Lahey Hospital and Medical Center /ID# 214724
    • Michigan
      • Ann Arbor, Michigan, United States, 48109
        • University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 164654
      • Chesterfield, Michigan, United States, 48047
        • Clin Res Inst of Michigan, LLC /ID# 170163
      • Farmington Hills, Michigan, United States, 48334-3230
        • Digestive Health Associates (DHA) - Farmington Hills /ID# 206101
      • Troy, Michigan, United States, 48098-6363
        • Center for Digestive Health /ID# 164726
    • Minnesota
      • Rochester, Minnesota, United States, 55905-0001
        • Mayo Clinic - Rochester /ID# 164691
    • Mississippi
      • Jackson, Mississippi, United States, 39216
        • Southern Therapy and Advanced Research (STAR) LLC /ID# 165295
    • Nebraska
      • Omaha, Nebraska, United States, 68114-3723
        • Quality Clinical Research Inc. /ID# 170162
      • Omaha, Nebraska, United States, 68124
        • CHI Health Research Center /ID# 168513
    • Nevada
      • Las Vegas, Nevada, United States, 89113
        • Las Vegas Medical Research /ID# 168551
    • New Jersey
      • Egg Harbor, New Jersey, United States, 08234
        • Cooper Gastroenterology at Fire Road /ID# 164641
      • New Brunswick, New Jersey, United States, 08901
        • Rutgers Robert Wood Johnson /ID# 166110
    • New York
      • Brooklyn, New York, United States, 11235
        • NY Scientific /ID# 164630
      • Johnson City, New York, United States, 13790-2107
        • United Health Services Hospitals, Inc /ID# 217483
      • Lake Success, New York, United States, 11042
        • NYU Langone Long Island Clinical Research Associates /ID# 164627
      • New York, New York, United States, 10029
        • The Mount Sinai Hospital /ID# 170256
      • New York, New York, United States, 10032-3725
        • Columbia Univ Medical Center /ID# 164692
      • Rochester, New York, United States, 14618-5703
        • Gastoenterology Group of Rochester /ID# 166235
      • Staten Island, New York, United States, 10310-1664
        • Richmond University Medical Center /ID# 201858
      • The Bronx, New York, United States, 10467
        • Montefiore Medical Center - Moses Campus /ID# 166242
      • The Bronx, New York, United States, 10468
        • Advantage Clinical Trials /ID# 168582
    • North Carolina
      • Charlotte, North Carolina, United States, 28203
        • Atrium Health Carolinas Medical Center /ID# 164632
      • Charlotte, North Carolina, United States, 28209
        • Duplicate_PMG Research of Charlotte /ID# 171178
      • Raleigh, North Carolina, United States, 27612
        • Wake Radiology UNC REX Healthcare - Raleigh Office /ID# 164752
      • Winston-Salem, North Carolina, United States, 27157-0001
        • Duplicate_Atrium Health Wake Forest Baptist Medical Center /ID# 164755
    • North Dakota
      • Fargo, North Dakota, United States, 58104-5925
        • Plains Clinical Research Center, LLC /ID# 170169
    • Ohio
      • Cincinnati, Ohio, United States, 45219
        • Gastro Health Research /ID# 164668
      • Cincinnati, Ohio, United States, 45267-0585
        • Duplicate_Duplicate_University Of Cincinnati Medical Center /ID# 164729
      • Cleveland, Ohio, United States, 44195
        • Cleveland Clinic Main Campus /ID# 209230
      • Columbus, Ohio, United States, 43210
        • Ohio State University/ Gastroe /ID# 170159
      • Columbus, Ohio, United States, 43235
        • Optimed Research, Ltd. /ID# 205625
      • Dayton, Ohio, United States, 45424
        • Hometown Urgent Care and Resea /ID# 201289
      • Englewood, Ohio, United States, 45415
        • Dayton Gastroenterology, Inc. /ID# 167623
      • Mentor, Ohio, United States, 44060-6211
        • Great Lakes Gastroenterology Research, LLC /ID# 202006
    • Oklahoma
      • Oklahoma City, Oklahoma, United States, 73112
        • Digestive Disease Specialists /ID# 201063
      • Tulsa, Oklahoma, United States, 74104
        • Options Health Research, LLC /ID# 164704
      • Tulsa, Oklahoma, United States, 74135
        • Healthcare Research Consultant /ID# 166244
    • Pennsylvania
      • Philadelphia, Pennsylvania, United States, 19104-5502
        • University of Pennsylvania /ID# 168406
      • Philadelphia, Pennsylvania, United States, 19107-4414
        • Duplicate_Thomas Jefferson University /ID# 168003
    • South Carolina
      • Charleston, South Carolina, United States, 29412
        • Pharmacorp Clinical Trials /ID# 165008
      • Greenville, South Carolina, United States, 29607
        • Gastroenterology Associates, P.A. of Greenville /ID# 164643
    • South Dakota
      • Rapid City, South Dakota, United States, 57701
        • Rapid City Medical Center - GI Research /ID# 201733
    • Tennessee
      • Cordova, Tennessee, United States, 38018
        • Gastro One /ID# 164730
      • Johnson City, Tennessee, United States, 37604
        • Duplicate_East Tennessee Research Institute /ID# 203614
      • Nashville, Tennessee, United States, 37211
        • Quality Medical Research /ID# 205264
      • Nashville, Tennessee, United States, 37232-0011
        • Vanderbilt University Medical Center /ID# 164607
    • Texas
      • Arlington, Texas, United States, 76012
        • TX Clinical Research Institute /ID# 164719
      • Baytown, Texas, United States, 77521-2415
        • Inquest Clinical Research /ID# 164676
      • Cedar Park, Texas, United States, 78613
        • GI Alliance /ID# 209803
      • Dallas, Texas, United States, 75246
        • Baylor Scott & White Center for Inflammatory Bowel Diseases /ID# 170161
      • Houston, Texas, United States, 77058
        • Centex Studies, Inc. - Houston /ID# 201212
      • Houston, Texas, United States, 77070-4347
        • GI Specialists of Houston /ID# 202340
      • Houston, Texas, United States, 77030
        • Baylor College of Medicine /ID# 164609
      • Lubbock, Texas, United States, 79424
        • Caprock Gastro Research - Lubbock - 80th Street /ID# 215436
      • San Antonio, Texas, United States, 78212
        • Clinical Associates in Research Therapeutics of America, LLC /ID# 164675
      • San Antonio, Texas, United States, 78229-5390
        • Southern Star Research Institute, LLC /ID# 169756
      • Sugar Land, Texas, United States, 77478
        • Carl R. Meisner Medical Clinic /ID# 171057
      • Tyler, Texas, United States, 75701
        • Tyler Research Institute, LLC /ID# 168679
      • Victoria, Texas, United States, 77904
        • Gastro Health & Nutrition - Victoria /ID# 167810
      • Webster, Texas, United States, 77598
        • Texas Digestive Disease Consultants /ID# 209954
    • Utah
      • Bountiful, Utah, United States, 84010
        • HP Clinical Research /ID# 164631
      • Ogden, Utah, United States, 84405
        • Advanced Research Institute /ID# 164689
      • Salt Lake City, Utah, United States, 84124-1377
        • Duplicate_Care Access Research /ID# 164685
      • West Jordan, Utah, United States, 84088
        • Duplicate_Velocity Clinical Research - Salt Lake City /ID# 166113
    • Washington
      • Bellevue, Washington, United States, 98004
        • Texas Digestive Disease Consultants, PLLC dba GI Alliance /ID# 164728
      • Seattle, Washington, United States, 98109
        • University of Washington /ID# 164646
      • Seattle, Washington, United States, 98101
        • Virginia Mason Hospital & Medical Center /ID# 164862
      • Vancouver, Washington, United States, 98664
        • The Vancouver Clinic, INC. PS /ID# 164874
    • Wisconsin
      • Milwaukee, Wisconsin, United States, 53226-3522
        • Froedtert Memorial Lutheran Hospital /ID# 202285
      • Wauwatosa, Wisconsin, United States, 53226
        • Allegiance Research Specialists /ID# 165298

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

14 years to 71 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

For Substudy 1:

  • Participant who achieve clinical response in Study M14-431 or Study M14-433.
  • Participant completes study procedures in the parent study. The final endoscopy for Studies M14-431 or M14-433 may be missing, if the endoscopy cannot be performed during the COVID-19 pandemic.

For Substudy 2:

  • Participant completes Substudy 1. The Week 52 endoscopy may be missing, if the endoscopy cannot be performed during the COVID-19 pandemic.
  • Participant who achieved clinical response at the time described in the protocol and completes study procedures in the parent study/ substudy.

Exclusion Criteria:

For Substudies 1 and 2:

  • Participant is considered by the investigator, for any reason, to be an unsuitable candidate for the study.
  • Participant who has a known hypersensitivity to upadacitinib or its excipients, or had an adverse event during Studies M14-431 and M14-433 or Substudy 1 or 2 of Study M14-430 that in the investigator's judgment makes the participant unsuitable for this study.
  • Participant at the final visit of M14-431 or M14-433 with any active or chronic recurring infections based on the investigator's assessment that makes the participant an unsuitable candidate for the study. Participants with serious infections undergoing treatment may be enrolled BUT NOT dosed until the infection treatment has been completed and the infection is resolved, based on the investigator's assessment.
  • Participants with high grade colonic dysplasia or malignancy diagnosed at the endoscopy performed at the final visit of Studies M14-431, M14-433 or Substudy 1 of Study M14-430 (Week 52).

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Sequential Assignment
  • Masking: Quadruple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Substudy 1: Cohort 1 Upadacitinib Dose A
This is a maintenance group which includes participants who achieved clinical response to upadacitinib in studies M14-431 and M14-433 and will receive upadacitinib dose A for 52 weeks.
Drug: Upadacitinib
Oral; Tablet
Other Names:
  • RINVOQ
  • ABT-494
Experimental: Substudy 1: Cohort 1 Upadacitinib Dose B
This is a maintenance group which includes participants who achieved clinical response to upadacitinib in studies M14-431 and M14-433 and will receive upadacitinib dose B for 52 weeks.
Drug: Upadacitinib
Oral; Tablet
Other Names:
  • RINVOQ
  • ABT-494
Experimental: Substudy 1: Cohort 1 Placebo
This is a maintenance group which includes participants who achieved clinical response to upadacitinib in studies M14-431 and M14-433 and will receive placebo for 52 weeks.
Drug: Placebo for Upadacitinib
Oral; Tablet
Experimental: Substudy 1: Cohort 2 Placebo
This is a maintenance group which includes participants who received double-blind placebo in studies M14-431 and M14-433 and achieved clinical response will continue to receive blinded placebo for 52 Weeks.
Drug: Placebo for Upadacitinib
Oral; Tablet
Experimental: Substudy 1: Cohort 3 Upadacitinib Dose B
This is a maintenance group which includes participants who achieved clinical response to upadacitinib from the extended treatment period of studies M14-431 and M14-433 and will receive upadacitinib Dose B for 52 Weeks.
Drug: Upadacitinib
Oral; Tablet
Other Names:
  • RINVOQ
  • ABT-494
Experimental: Substudy 2: Cohort 4 Upadacitinib Dose B
This is a long-term extension group which includes participants who achieved clinical response in the open-label extended treatment period of study M14-431 and will receive upadacitinib dose B for 240 weeks.
Drug: Upadacitinib
Oral; Tablet
Other Names:
  • RINVOQ
  • ABT-494
Experimental: Substudy 2: Cohort 5 Upadacitinib Dose A
This is a long-term extension group which includes participants who complete Substudy 1 and will receive upadacitinib dose A for 240 weeks.
Drug: Upadacitinib
Oral; Tablet
Other Names:
  • RINVOQ
  • ABT-494
Experimental: Substudy 2: Cohort 5 Upadacitinib Dose B
This is a long-term extension group which includes participants who complete Substudy 1 and will receive upadacitinib dose B for 240 weeks.
Drug: Upadacitinib
Oral; Tablet
Other Names:
  • RINVOQ
  • ABT-494
Experimental: Substudy 2: Cohort 5 Placebo
This is a long-term extension group which includes participants who complete Substudy 1 and will receive placebo for 240 weeks.
Drug: Placebo for Upadacitinib
Oral; Tablet

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Sub-Study 1: Percentage of Participants with Clinical Remission per Crohn's Disease Activity Index (CDAI)
Time Frame: Week 52
Clinical remission per CDAI is defined as CDAI <150.
Week 52
Sub-Study 1: Percentage of Participants with Endoscopic Response
Time Frame: Week 52
Endoscopic response is defined as decrease in Simple Endoscopic Score for Crohn's Disease (SES-CD) from Baseline.
Week 52
Number of Participants with Adverse Events
Time Frame: Through Week 240
An adverse event (AE) is defined as any untoward medical occurrence in a patient or clinical investigation participant administered a pharmaceutical product and which does not necessarily have a causal relationship with this treatment. The investigator assessed the relationship of each event to the use of study drug as either probably related, possibly related, probably not related or not related. A serious adverse event (SAE) is an event that results in death, is life-threatening, requires or prolongs hospitalization, results in a congenital anomaly, persistent or significant disability/incapacity or is an important medical event that, based on medical judgment, may jeopardize the participant and may require medical or surgical intervention to prevent any of the outcomes listed above. For more details on adverse events please see the Adverse Event section.
Through Week 240

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Sub-Study 1: Percentage of Participants with Clinical Remission per Patient-Reported Outcomes (PROs)
Time Frame: Week 52
Clinical remission is defined based on average daily stool frequency (SF) AND average daily abdominal pain (AP) score.
Week 52
Sub-Study 1: Percentage of Participants Achieving Clinical Response 100 (CR-100)
Time Frame: Week 52
Decrease of at least 100 points in CDAI from Baseline.
Week 52
Sub-Study 1: Percentage of Participants with Endoscopic Remission
Time Frame: Week 52
Endoscopic remission is defined per Simplified Endoscopic Score for Crohn's Disease (SES-CD).
Week 52
Sub-Study 1: Percentage of Participants without Corticosteroid use for Crohn's Disease Among All Participants
Time Frame: Week 52
This is assessed in participants not taking corticosteroids at least 90 days prior to Week 52 and achieved clinical remission per CDAI. Clinical remission is defined as CDAI <150.
Week 52
Sub-Study 1: Percentage of Participants with Clinical Remission per CDAI and Endoscopic Remission
Time Frame: Week 52
Clinical remission per CDAI is defined as CDAI <150. Endoscopic remission is defined per SES-CD.
Week 52
Sub-Study 1: Percentage of Participants who Discontinue Corticosteroid Use for Crohn's Disease at Least 90 Days Prior to Week 52 and Achieve Clinical Remission, in Participants Taking Corticosteroids at Baseline.
Time Frame: Week 52
This is assessed in participants taking corticosteroids at Baseline. Clinical remission is defined based on average daily stool frequency (SF) AND average daily abdominal pain (AP) score.
Week 52
Sub-Study 1: Change in Inflammatory Bowel Disease Questionnaire (IBDQ)
Time Frame: Baseline (Week 0) to Week 52
The IBDQ is used to assess the quality of life of patients with inflammatory bowel disease.
Baseline (Week 0) to Week 52
Sub-Study 1: Change in Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F)
Time Frame: Baseline (Week 0) to Week 52
The FACIT-F questionnaire was developed to assess fatigue.
Baseline (Week 0) to Week 52
Sub-Study 1: Percentage of Participants with Hospitalizations due to Crohn's Disease (CD)
Time Frame: Up to Week 52
This is assessed by reviewing participant's hospitalization data.
Up to Week 52
Sub-Study 1: Percentage of Participants with Resolution of Extra-Intestinal Manifestation (EIMs) , in Participants with EIMs at Baseline
Time Frame: Week 52
EIMs are defined as manifestations of Crohn's disease in areas of the body other than the digestive tract, including eyes, skin, joints, mouth, and liver.
Week 52
Sub-Study 1: Percentage of Participants with Clinical Remission per CDAI
Time Frame: Through Week 52
Clinical remission per CDAI is defined as CDAI <150 (as measured by the percentage of participants with clinical remission at Week 52 among those with clinical remission at Week 0).
Through Week 52

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

AbbVie

Investigators

  • Study Director: ABBVIE INC., AbbVie

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

March 21, 2018

Primary Completion (Estimated)

September 1, 2027

Study Completion (Estimated)

September 1, 2027

Study Registration Dates

First Submitted

November 15, 2017

First Submitted That Met QC Criteria

November 15, 2017

First Posted (Actual)

November 17, 2017

Study Record Updates

Last Update Posted (Actual)

April 9, 2026

Last Update Submitted That Met QC Criteria

April 6, 2026

Last Verified

April 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • M14-430
  • 2023-504951-29 (Other Identifier: EU CT)
  • 2023-504951-29-00 (Ctis)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

AbbVie is committed to responsible clinical trial data sharing. This includes access to anonymized, individual and trial-level data (analysis data sets), as well as other information.

IPD Sharing Time Frame

For details on when studies are available for sharing visit https://vivli.org/ ourmember/abbvie/

IPD Sharing Access Criteria

To learn more about the process, or to submit a request, visit the following link https://www.abbvieclinicaltrials.com/hcp/data-sharing/

IPD Sharing Supporting Information Type

  • STUDY_PROTOCOL
  • SAP

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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