Neural Mechanism Underlying Social Cognition in Depressive Patients

February 5, 2018 updated by: ma, yina, Beijing Normal University
In the project, investigators plan to test difference of social cognition between depressive patients and healthy individuals and the brain activation underlying the difference to further understand the neural mechanism of depressive disorder.

Study Overview

Status

Unknown

Conditions

Study Type

Observational

Enrollment (Anticipated)

25

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • China
      • Beijing, China
        • Recruiting
        • HuiLongGuan Hospital
        • Contact:
          • Yina Ma, Doctor
        • Principal Investigator:
          • Yina Ma, Doctor

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 60 years (Adult)

Accepts Healthy Volunteers

N/A

Genders Eligible for Study

All

Sampling Method

Probability Sample

Study Population

Individuals diagnosed with depression and healthy control

Description

Inclusion Criteria:

  • Age range between 18 and 60
  • Education experience above high school
  • Score for Hamilton's Depression Scale >=17
  • Diagnosis of depression through Scid

Exclusion Criteria:

  • Undergoing electric shock treatment in 3 months
  • Excluding those who with bipolar disorder
  • Excluding those who with postpartum depression
  • Excluding those who with hysteria

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
emotion recognition
Time Frame: Baseline
After viewing a video, participants will be asked to judge the person's attitude in the video. Through this paradigm, investigators could test emotional bias in social interaction in depressive patients.
Baseline
resting state
Time Frame: Baseline
In this part, investigators basically want to test the automatic neural activity for depressive patients while they are resting.
Baseline
self-reflection
Time Frame: Baseline
Participants will be asked to judge the discrepancy between actual self and ideal self.
Baseline
response to negative stimuli
Time Frame: Baseline
investigators used face-matching task to measure their response to negative stimuli. The participants will be asked to detect the identical face with same emotion.
Baseline
structure
Time Frame: Baseline
Investigators scanned structural images to detect the difference between clinical population and healthy population.
Baseline
white matter
Time Frame: Baseline
Investigators scanned DTI to detect the difference between clinical population and healthy population.
Baseline

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Beijing Normal University

Collaborators

Huilongguan Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 1, 2017

Primary Completion (Anticipated)

February 8, 2018

Study Completion (Anticipated)

March 1, 2018

Study Registration Dates

First Submitted

January 22, 2018

First Submitted That Met QC Criteria

January 22, 2018

First Posted (Actual)

January 29, 2018

Study Record Updates

Last Update Posted (Actual)

February 7, 2018

Last Update Submitted That Met QC Criteria

February 5, 2018

Last Verified

February 1, 2018

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • HLGdepression-fMRI

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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