Influence of Mango Intake of Skin Health in Postmenopausal Women (MSS)

Influence of Mango Intake on Skin Health in Postmenopausal Women

This study aims to investigate the effects on 16 weeks of mango intake on skin health in postmenopausal women. Half of the participants will receive 85g portions of mangoes while the other half receive 250g portions of mangos. Participants will be instructed to consume the specific portion 4 times a week, for a total duration of 16 weeks.

Study Overview

• Status: Completed
• Conditions: Wrinkle; Skin Red
• Intervention / Treatment: Other: 16 weeks mango intake

Detailed Description

Mangoes are rich in carotenoids, flavonoids, vitamins and other active phytochemicals such as resistant starches. Although a role of mangoes in skin health has long been advocated in traditional medicine, little scientific research has been conducted.

We hypothesize that 85g (0.5 cups) of mango intake for 16 weeks will have minimal impact on skin health, while 250g (1.5 cups) of mango intake will produce significant benefits.

• Study Type: Interventional
• Enrollment (Actual): 36
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • California
    • Davis, California, United States, 95616
      • Ragle Human Nutrition Research Center

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 46 years to 66 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Female

Description

Inclusion Criteria:

• Postmenopausal
• Fitzpatrick skin type I and II
• BMI 18.5 - 35.0 kg/m2
• Normal blood levels in the comprehensive metabolic panel, or values slightly out of range as approved by the study physician

Exclusion Criteria:

• Allergic to mangoes
• Fruit consumption of 2 or more cups per day
• Vegetable consumption of 3 or more cups per day for females
• Fruit juice consumption of more than 1 cup per day
• Self-reported malabsorption
• Currently taking regular prescription drugs i.e. statins, thyroid, anti-inflammatory drugs
• Had any medical or cosmetic procedures such as laser resurfacing or plastic surgery to the face within the last 6 months, including botulinum toxin, dermal fillers, collagen or other similar cosmetic procedure
• Autoimmune photosensitive condition or known genetic condition with a deficiency in collagen production (such as Ehler-Danlos)
• Smoking (current smoker, smoked within the past year, former smokers with greater than a 20 pack-year history of smoking within the past 20 years.
• Indications of substance or alcohol abuse
• Unwillingness to discontinue high antioxidant supplements during washout and interventions

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: High mango group; 250g (1.5 cup) of mango intake per day, 4 days a week for 16 weeks	Other: 16 weeks mango intake; Participants will be provided fresh frozen Ataulfo mangoes.
Other: Low mango group; 85g (0.5 cup) of mango intake per day, 4 days a week for 16 weeks	Other: 16 weeks mango intake; Participants will be provided fresh frozen Ataulfo mangoes.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Skin Wrinkle Depth and Redness	Using a skin camera from BrighTex Bio-Photonics to measure change in skin wrinkle depth and redness within a period of 16 weeks.	0, 8, and 16 week
Skin carotenoid	Using a skin photometer (Veggie Meter) to measure change in skin carotenoid within a period of 16 weeks.	0, 4, 8, 12, and 16 weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Sebum	Sebum will be collected with sebutapes from the face and stored for possible further analysis.	0, 8, 16, weeks
Plasma carotenoid	Plasma samples will be collected and stored at -80C for possible further analysis	0, 8, 16 weeks.

Collaborators and Investigators

• Sponsor: University of California, Davis
• Collaborators: National Mango Board

Study record dates

Study Major Dates

• Study Start (Actual): July 17, 2018
• Primary Completion (Actual): May 31, 2019
• Study Completion (Actual): May 31, 2019

Study Registration Dates

• First Submitted: July 3, 2018
• First Submitted That Met QC Criteria: July 16, 2018
• First Posted (Actual): July 18, 2018

Study Record Updates

• Last Update Posted (Actual): October 14, 2019
• Last Update Submitted That Met QC Criteria: October 10, 2019
• Last Verified: October 1, 2019

More Information

Terms related to this study

• Keywords: Mango; Carotenoid; Skin Health; Skin Wrinkle; Skin Redness
• Additional Relevant MeSH Terms: Skin Diseases; Skin Manifestations; Erythema
• Other Study ID Numbers: 1185928

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No