- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03833102
Prospective Study of Staphylococcus Aureus Clinical Isolates Versus Colonization: RNAs as Potential Biomarkers for Bloodstream Infections (PROSAC)
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
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Rennes, France, 35033
- Centre Hospitalier Universitaire de Rennes
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- Patient over 18 years of age;
Patients hospitalized at the University Hospital of Rennes, with according to groups:
: Colonized subjects:
- Any patient hospitalized at the University Hospital of Rennes, or any health professional, in whom a colonization screening with S. aureus is performed in routine care and a colonization with S. aureus is documented;
(For information, this screening is carried out frequently at the University Hospital of Rennes for different reasons (before surgery or procedure requiring the installation of equipment, screening of contact cases of infected cases, investigation during a nosocomial epidemic...). These people are hospitalized for reasons other than S. aureus infection and in different departments, but the samples are collected centrally in the institution's bacteriology laboratory.)
: Patients hospitalized for BSA:
- Patients hospitalized in the infectious diseases and medical intensive care unit and in the surgical intensive care unit, for whom a BSA is documented at the bacteriology laboratory of the University Hospital of Rennes;
- Patients for whom nasal carrying screening for S. aureus is prescribed as part of their management;
These patients will be classified into two groups:
- Serious clinic (CG):
- BSA ;
Associated with signs of sepsis according to the 20168 international definition:
- SOFA score (see Appendix 3) 2 ;
Septic shock will be defined as the existence of sepsis associated with persistent low blood pressure requiring the administration of vasopressors to obtain an average blood pressure (MAP) 65 mmHg and an arterial lactate dosage 2 mmol/L despite adequate vascular filling.
2) Non-serious clinic (CNG):
- BSA ;
- Which does not meet the definition of the CG group.
- Having expressed their opposition to this research or whose trusted person does not oppose the research if the patient is not able to give an informed opinion.
Exclusion Criteria:
- Pregnant or breastfeeding women;
- Persons of full age who are subject to legal protection (protection of justice, guardianship, guardianship), persons deprived of their liberty;
- S. aureus strain producing leucocidin from Panton-Valentine;
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Colonized patients' group (CPG)
all adult patients hospitalized in or consulting the Rennes University Hospital, known as S. aureus colonized could be included.
In our institution, S. aureus colonization in the nostrils is screened in all patients supposed to undergo neurosurgical or orthopedic surgery.
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ST types will be determined for all individualized bacterial strains.
For all the bacterial strains, RNAs expression will be analyzed at three different growth phases: early exponential phase, mid exponential phase and early stationary phase.
Expression of RNAIII and SprD will be evaluated by quantitative polymerase chain reaction.
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SAB patients' group (SAB)
all adult patients with SAB could be included. S. aureus colonization in the nostrils will be systematically screened immediately after the first result of positive S. aureus blood culture. Two subgroups will be individualized depending on the SOFA Score:
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ST types will be determined for all individualized bacterial strains.
For all the bacterial strains, RNAs expression will be analyzed at three different growth phases: early exponential phase, mid exponential phase and early stationary phase.
Expression of RNAIII and SprD will be evaluated by quantitative polymerase chain reaction.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Levels of RNAIII expression and sprD in isolated strains of S. aureus from bacteremia
Time Frame: through study completion, an average of 1 year
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Levels of expression of RNAIII and sprD in isolated strains of S. aureus isolated from bacteremia, compared to these same levels of expression in strains from colonized, uninfected patients.
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through study completion, an average of 1 year
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Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Matthieu REVEST, Centre Hospitalier Universitairede Rennes
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 35RC17_9726_PROSAC
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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