- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03883672
Socio-psychological Factors Involved in the Hematopoietic Stem Cell Transplantation Process in People With Hemopathies (Psy-Greffe)
Study of the Role of Socio-psychological Factors in the Hematopoietic Stem Cell Transplantation Process in People With Hemopathies
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
To reach the research purposes, questionnaires will be given to patients at different times during the transplant process :
- Pre-admission transplant questionnaire: given and collected by the transplant physician during the pre-graft consultation before entering hospitalization (approximatively 15 days before). To be completed by the patient on site (approximately 45 minutes to complete the questionnaire)
- Transplant admission questionnaire: given during the first days of hospitalization. To be completed within 6 days and returned to the transplant physician (approximately 30 minutes to complete the questionnaire)
- Post-transplant follow-up questionnaire: given in consultation at 6 months by the transplant physician (between 30 and 45 minutes to complete the questionnaire in consultation)
The questionnaires include validated and standardized scales.
The first questionnaire contains scales on dispositional factors (i.e. personality factors) . The second one is on the so-called transactional adjustment factors. And the third is on post-transplant factors (e. g. post-traumatic growth). Scales from the first and second questionnaire will be used to obtain a longitudinal view.
The study population concerns all patients going to receive an allograft transplantation, aged over 18 years, who have consented to answer the various questionnaires over a period of approximately 7 months . The participants come from the hematology departments of the Saint-Louis Hospital in Paris, the Estaing University Hospital in Clermont-Ferrand and the Brabois Hospital in Nancy.
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
-
Paris, France, 75475
- Régis Peffault De Latour
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- patient with hematopathy with allograft HSC indication
- allograft protocol
- patient over 18 years of age
- patient who has read and understood the information note and who has consented has not objected to participating in the research
- patient affiliated to a social security system (beneficiary )
Exclusion Criteria:
- patients receiving autograft
- patient under 18 years of age
- patient under guardianship or curatorship
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Other
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: hematopoietic stem cell transplantation
Personality and transactional factors involved in the process and outcomes of hematopoietic stem cell transplantation
|
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Five Facets Mindfulness Questionnaire (FFMQ)
Time Frame: 15 days before hospitalization
|
Assessement of Mindfulness level as a dispositional dimension.
Baert et al., 2006 ; Heeren et al., 2011 39-items scale 5 underscores for each facets of mindful trait: to observe (8 items, max=40), to describe (8 items, max= 40), to act with awareness (8 items, max= 40), to non judge (8 items, max= 40, to non react (7 items, max= 35) Range for full scale: [39-195] More the score is high more the mindfulness level is high.
No pathological score
|
15 days before hospitalization
|
General Self Efficacy Scale (GSES)
Time Frame: 15 days before hospitalization
|
Assessment of Perceived Self Efficacy level (e.g.
Am I think myself able to do something ?)
Schwarzer & Jerusalem, 1995 10-items scale.
The total score is the sum of all items.
Range for full scale : [10-40] More the score is high more the general self efficacy level is high.
No pathological score
|
15 days before hospitalization
|
Authentic sustainable happiness scale (ASHS)
Time Frame: 15 days before hospitalization
|
Dambrun et al. (2012) Assessment of a happiness component through 13 items (e.g.: satisfaction, general well-being, serenity, etc.). 2 happiness subscales to sum for obtain the total score of hapiness: "contentment" (8 items) and "inner peace" (5 items). Range for full scale: [13-91]. Range for "contentment subscale": [8-56]. range for "inner peace" subscale: [5-35]. More the score is high, more the level of authentic and sustainable happiness is high. No pathological score. Dambrun et al., 2012 16-items scale |
15 days before hospitalization
|
Authentic sustainable happiness scale (ASHS)
Time Frame: 6 months after hospitalization
|
Dambrun et al. (2012) Assessment of a happiness component through 13 items (e.g.: satisfaction, general well-being, serenity, etc.). 2 happiness subscales to sum for obtain the total score of hapiness: "contentment" (8 items) and "inner peace" (5 items). Range for full scale: [13-91]. Range for "contentment subscale": [8-56]. range for "inner peace" subscale: [5-35]. More the score is high, more the level of authentic and sustainable happiness is high. No pathological score. Dambrun et al., 2012 16-items scale |
6 months after hospitalization
|
Life Orientation Test-Revised (LOT-R)
Time Frame: 15 days before hospitalization
|
Assessment of dispositional Optimism level Scheier, Carver & Bridge,1994 10-items scale: 6 items assessing optimism component and 4 fillers.
The total score is the sum of the 6 items.
Range for the total scale: [6-42].
More the score is high, more the optimism level is high.
No pathological score.
|
15 days before hospitalization
|
Adult Dispositional Hope Scale (ADHS)
Time Frame: 15 days before hospitalization
|
Assessement of Dispositional Hope level of people.
Snyder et al., 1991 ; Gana et al., 2012 12-items scale.
range for the full scale: [8-64]. 2 subscales: "agency" (4 items, [4-32]), "pathways" (4 items, [4-32]) and 4 fillers.
The total score is the sum of the 8 items.
More the score is high, more the dispositional hope level is high.
No pathological score.
|
15 days before hospitalization
|
Acceptance and Action Questionnaire-version 2 (AAQ-II)
Time Frame: 15 days before hospitalization
|
Assessement of two dimensions of psychological flexibility (involved in a good mental health) Bond et al., 2011 ; Monestès et al., 2009 10-items scale.
Range for the full scale [10-70].
The total score is the sum of the 10 items.
More the the score is high, more the psychological flexibility is high.
No pathological score
|
15 days before hospitalization
|
Single Item Self Esteem (SISE)
Time Frame: 15 days before hospitalization
|
Assessment of self-esteem dimension Robins et al., 2001 1-item scale. Range of the item [1-7]. More the score is high, more the self-esteem level is high. No pathological score. |
15 days before hospitalization
|
Ego Resiliency Scale-revised (EGO-R-r)
Time Frame: 15 days before hospitalization
|
Assessment of Resiliency as a dispositional dimension. 2 subscales: "optimal regulation" (6 items, [6-42] and "openness to life experience" (4 items, [4-28]). Range for the full scale: [10-70]. The total score is the sum of the 2 subscales scores (10 items). More the score is high, more the resiliency level is high. No pathological score. Alessandri, Vecchione, Caprara, & Letzring, 2011 10-items scale |
15 days before hospitalization
|
Avoidance and Fusion Questionnaire for Adults (AFQ)
Time Frame: 15 days before hospitalization
|
Assessement of experiential avoidance and fusion, 2 dimensions of psychological inflexibility (involved in the maintenance of emotional disorders as depression or anxiety) Fergus et al., 2012 17-items scale.
Range for the full scale: [0-68].
The total score is the sum of the 17 items.
More the score is high, more the psychological inflexibility is high.
No pathological score
|
15 days before hospitalization
|
Hospital Anxiety and Depression Scale
Time Frame: 15 days before hospitalization
|
Assessement of anxiety and depression symptoms for hospitalized people Zigmond & Snaith, 1983 14-items scale 2 underscores: "depression" score (7 items) and "anxiety" score (7 items).
One score for depression is computed (sum of 7 items, [0-21] and one for "anxiety" is computed too (sum of 7 items, [0-21]).
For each subscales: a score under 7 is not pathological; between 8 and 10 there is a suspicion of symptomatology; and beyond 11 means an established symptomatology.
|
15 days before hospitalization
|
Hospital Anxiety and Depression Scale
Time Frame: 6 months after hospitalization
|
Assessement of anxiety and depression symptoms for hospitalized people Zigmond & Snaith, 1983 14-items scale 2 underscores: "depression" score (7 items) and "anxiety" score (7 items).
One score for depression is computed (sum of 7 items, [0-21] and one for "anxiety" is computed too (sum of 7 items, [0-21]).
For each subscales: a score under 7 is not pathological; between 8 and 10 there is a suspicion of symptomatology; and beyond 11 means an established symptomatology.
|
6 months after hospitalization
|
Toronto Alexithymia Scale-20 (TAS-20)
Time Frame: 15 days before hospitalization
|
Assessment of alexithymia level (i.e.
difficulties in experiencing and expressing feelings) Bagby, Parker & Taylor, 2003 ; Loas et al., 1997 20-items scale.
Range for the full scale: [20-100].
3 subscales: "difficulty identifying feelings" (7 items, [7-35]), "difficulty describing feelings to others" (5 items, [5-25]), "externally oriented thinking" (8 items, [8-40]).
A score beyond 61 is considered as pathological.
|
15 days before hospitalization
|
Positive Affect and Negative Affect Schedule (PANAS)
Time Frame: 15 days before hospitalization
|
Assessment of positive affectivity (curious, motivated, enthusiastic, proud, etc.) and negative affectivity (guilty, nervous, anguished,etc.)
levels Watson, Clark & Tellegen, 1988 ; Caci & Baylé, 2007 20-items scale. 2 underscores: positive affectivity score (10 items, [10-50]) and negative affectivity score (10 items, [10-50]).
More the score is high for each subscale, more the experience of positive/ negative affectivity is high.
No pathological score.
|
15 days before hospitalization
|
Big Five Inventory (BFI)
Time Frame: 15 days before hospitalization
|
Assessment of 5 personality dimensions: extraversion (8 items, [8-40], openness (10 items, [10-50]), consciousness (9 items, [9-45]), agreeableness (8 items, [8-40]) and neuroticism (8 items, [8-40]). John & Srivastava, 1999 ; Plaisant et al., 2010 45-items scale 5 underscores for each personality facet. More the score is high for each personality facet, more the level of extraversion/ openness/ consciousness/ agreeableness/neuroticism is high. No pathological score. |
15 days before hospitalization
|
Body boundaries scale (BBS)
Time Frame: 15 days before hospitalization
|
Assessment of perceived boundaries of body: prominent boundaries or not prominent boundaries are the two extremes of the continuum Dambrun & Ricard, 2012 Analogic scale.
range for the full scale [0-15].
More the score is high more the body boundaries are prominent.
No pathological score.
|
15 days before hospitalization
|
General Questionnaire SF-12: mental and social quality of life
Time Frame: 15 days before hospitalization
|
Mental and social quality of life assessment 12-items scale.
For each item one standardized score of mental and social quality of life is computed ( [5,89058 ; 71,96825])and one standardized score is computed for the physical quality of life ([9,94738 ; 70,02246]). the mean among the general population is 50.
More the score is high, more the level of quality of life is high.
|
15 days before hospitalization
|
General Questionnaire SF-12: mental and social quality of life
Time Frame: 6 months after hospitalization
|
Mental and social quality of life assessment 12-items scale.
For each item one standardized score of mental and social quality of life is computed ( [5,89058 ; 71,96825])and one standardized score is computed for the physical quality of life ([9,94738 ; 70,02246]). the mean among the general population is 50.
More the score is high, more the level of quality of life is high
|
6 months after hospitalization
|
Social Provisions scale revised
Time Frame: At the 7th day of hospitalization
|
Perceived social support assessment in different settings (attachment, reliable alliance, social integration, reassurance of worth, guidance, ...) Cutrona & Russel, 1987 24-items scale.
Range for the full scale [16-96].
4 items for each subscale (range for each subscales: [4-16]).
The total score is the sum of all subscales scores.
More the score is high, more the social support is high.
No pathological score.
|
At the 7th day of hospitalization
|
Perceived Stress Scale (PSS)
Time Frame: At the 7th day of hospitalization
|
Assessement of perceived stress level (i.e. How much life situations are threatening, unpredictable and uncontrollable). Cohen, Karmack, Mermelstein, 1983 10-items scale. range for the full scale: [0-40]. The total score is the sum of all the 10 items. Between 0 and 13: low level of perceived stress. Between 14 and 26: middle level of perceived stress. Between 27and 40: high level of perceived stress. |
At the 7th day of hospitalization
|
Mental Adjustment to Cancer Scale (MACs)
Time Frame: At the 7th day of hospitalization
|
Coping strategies assessment (i.e. What kind of behavioral or emotional strategies are put in place to cope with stressful events). 5 strategies assessed: fighting spirit, avoidance, helplessness-hopelessness, anxious preoccupations, denial. Watson et al., 1998 ; Cayrou et al., 2003 45-items scale. For each strategy a score is computed: fighting spirit ([13;52], 14 items), avoidance ([5; 20], 5 items), helplessness-hopelessness ([11;44] ,11 items), anxious preoccupations ([12; 48],12 items), denial ([3; 12], 3 items). More the score is high for each subscale, more the fighting spirit / avoidance/ helplessness-hopelessness/ anxious preoccupations/ denial strategy is used. No pathological score |
At the 7th day of hospitalization
|
Mental Adjustment to Cancer Scale (MACs)
Time Frame: 6 months after hospitalization
|
Coping strategies assessment (i.e. What kind of behavioral or emotional strategies are put in place to cope with stressful events). 5 strategies assessed: fighting spirit, avoidance, helplessness-hopelessness, anxious preoccupations, denial. Watson et al., 1998 ; Cayrou et al., 2003 45-items scale. For each strategy a score is computed: fighting spirit ([13;52], 14 items), avoidance ([5; 20], 5 items), helplessness-hopelessness ([11;44] ,11 items), anxious preoccupations ([12; 48],12 items), denial ([3; 12], 3 items). More the score is high for each subscale, more the fighting spirit / avoidance/ helplessness-hopelessness/ anxious preoccupations/ denial strategy is used. No pathological score |
6 months after hospitalization
|
Levenson scale - Internality- Power of others and Hasard scale (IPAH scale )
Time Frame: At the 7th day of hospitalization
|
Assessment of 3 locus of control facets : Internality; externality (power of others); externality (chance). This scale aims to determine to whom or what do individuals attribute the reasons for the occurrence of an event. Jutras, 1987 24-items scale. 3 underscores are computed: internality score (8 items, [6-48]), externality/ power of others (8 items, [6-48]) and externality/ hasard (8 items, [6-48]). More the score for each subscale is high more the internality / externality level is high. No pathological score. |
At the 7th day of hospitalization
|
Brief Strengths Test
Time Frame: At the 7th day of hospitalization
|
Assessement of personal strengths involved in resiliency, good mental health, happiness. Clustered in 6 different virtues : wisdom and knowledge, courage, humanity, justice, temperance, transcendence. Park, Peterson & Seligman, 2004 24-items scale. range for the full scale: [24-120]. 6 underscores are computed for each virtue: wisdom and knowledge (5 items, [5-25]), courage (4 items, [4-20]), humanity (3 items, [3-15]), justice (3 items, [3-15]), temperance (4 items, [4-20]), transcendence (5 items, [5-25]). More the score is high, more the level of wisdom and knowledge/ courage/ humanity/ justice/ temperance/ transcendence is high. No pathological score. |
At the 7th day of hospitalization
|
Brief Strengths Test
Time Frame: 6 months after hospitalization
|
Assessement of personal strengths involved in resiliency, good mental health, happiness. Clustered in 6 different virtues : wisdom and knowledge, courage, humanity, justice, temperance, transcendence. Park, Peterson & Seligman, 2004 24-items scale. range for the full scale: [24-120]. 6 underscores are computed for each virtue: wisdom and knowledge (5 items, [5-25]), courage (4 items, [4-20]), humanity (3 items, [3-15]), justice (3 items, [3-15]), temperance (4 items, [4-20]), transcendence (5 items, [5-25]). More the score is high, more the level of wisdom and knowledge/ courage/ humanity/ justice/ temperance/ transcendence is high. No pathological score. |
6 months after hospitalization
|
Positive orientation to others scale
Time Frame: At the 7th day of hospitalization
|
Assessment of positive orientation to others level.
Braithwaite & Law, 1985 13-items scale.
range for the full scale: [13-91].
The total score is the sum of the 13 items.
More the score is high, more the orientation to others level is high.
No pathological score
|
At the 7th day of hospitalization
|
Positive orientation to others scale
Time Frame: 6 months after hospitalization
|
Assessment of positive orientation to others level.
Braithwaite & Law, 1985 13-items scale.
range for the full scale: [13-91].
The total score is the sum of the 13 items.
More the score is high, more the orientation to others level is high.
No pathological score
|
6 months after hospitalization
|
Intrinsic spirituality scale
Time Frame: At the 7th day of hospitalization
|
Assessment of spirituality dimension.
How much people think spirituality is important for them?
Hodge, 2003 6-items scale.
Range for the full scale: [0-60].
The total score is the sum of the 6 items.
More the score is high, more the intrinsic spirituality level is high.
No pathological score
|
At the 7th day of hospitalization
|
Intrinsic spirituality scale
Time Frame: 6 months after hospitalization
|
Assessment of spirituality dimension.
How much people think spirituality is important for them?
Hodge, 2003 6-items scale.
Range for the full scale: [0-60].
The total score is the sum of the 6 items.
More the score is high, more the intrinsic spirituality level is high.
No pathological score
|
6 months after hospitalization
|
Satisfaction with Life Scale
Time Frame: At the 7th day of hospitalization
|
Assessment of cognitive component of happiness. This is a general assessment of people life. Diener et al.,1985 5-items scale. Range for the full scale: [5-35]. [5-9] : extremely dissatisfied; [10-14]: dissatisfied; [15-19]: slightly dissatisfied; 20: neutral; [21-25]: slightly satisfied; [26-30]: satisfied; [31-35]: extremely satisfied. |
At the 7th day of hospitalization
|
Satisfaction with Life Scale
Time Frame: 6 months after hospitalization
|
Assessment of cognitive component of happiness. This is a general assessment of people life. Diener et al.,1985 5-items scale. Range for the full scale: [5-35]. [5-9] : extremely dissatisfied; [10-14]: dissatisfied; [15-19]: slightly dissatisfied; 20: neutral; [21-25]: slightly satisfied; [26-30]: satisfied; [31-35]: extremely satisfied. |
6 months after hospitalization
|
Personal Growth scale
Time Frame: At the 7th day of hospitalization
|
Assessment of one dimension of psychological well-being.
Ryff & Essex, 1992 14-items scale.
range for the full scale: [14-84].
Total score is the sum of the 14 items.
More the score is high, more the level of personal growth is high.
No pathological score.
|
At the 7th day of hospitalization
|
Personal Growth scale
Time Frame: 6 months after hospitalization
|
Assessment of one dimension of psychological well-being.
Ryff & Essex, 1992 14-items scale.
range for the full scale: [14-84].
Total score is the sum of the 14 items.
More the score is high, more the level of personal growth is high.
No pathological score.
|
6 months after hospitalization
|
Post Traumatic Growth Inventory
Time Frame: 6 months after hospitalization
|
Assessment of post traumatic growth level which encountered with traumatized people. 5 different dimensions of PTG: changes in relationships , spirituality , personal growth , personal strength, new possibilities, life satisfaction. Tedeschi & Calhoun, 2004 ; Cadell, Suarez & Hemsworth, 2015 21-items scale. range for the full scale: [0-105]. The total is the sum of the 21 items 5 underscores are computed: changes in relationships (7 items, [0-35]) , spirituality (2 items, [0-10]) , personal strength (4 items, [0-20]), new possibilities (5 items, [0-25]),life satisfaction (3 items, [0-15]). More the score is high, more the level of post traumatic growth is high. No pathological score. |
6 months after hospitalization
|
Stress version of post traumatic stress disorder scale
Time Frame: 6 months after hospitalization
|
Assessment of traumatism level and traumatic symptomatology (e.g.
repetition of traumatic event)Weathers et al., 1993 17-items scale.
Range for the full scale: [17-85].
The total is the sum of the 17 items.
3 underscores are computed: "repetition of the traumatic event" (5 items, [5-25]), "avoidance" (7 items, [5-35]), "neurovegetative hyperactivity" (5 items, [5-25]).
A score beyond 44 is considered as pathological score.
|
6 months after hospitalization
|
Socio-demographic informations: Age
Time Frame: 15 days before hospitalization
|
year
|
15 days before hospitalization
|
Socio-demographic informations: sex
Time Frame: 15 days before hospitalization
|
2 propositions: man or woman
|
15 days before hospitalization
|
Socio-demographic informations: marital status
Time Frame: 15 days before hospitalization
|
5 propositions; single, couple, married, widowed, other
|
15 days before hospitalization
|
Socio-demographic informations: country
Time Frame: 15 days before hospitalization
|
people note the country where they were born
|
15 days before hospitalization
|
Socio-demographic informations: educational level
Time Frame: 15 days before hospitalization
|
What level of education (i.e.
degree)
|
15 days before hospitalization
|
Socio-demographic informations: socioprofessional category
Time Frame: 15 days before hospitalization
|
what a job it is
|
15 days before hospitalization
|
Socio-demographic informations: religion
Time Frame: 15 days before hospitalization
|
2 propositions: YES or NO
|
15 days before hospitalization
|
complementary informations: weight
Time Frame: 15 days before hospitalization
|
they indicate it in kilograms
|
15 days before hospitalization
|
complementary informations: size
Time Frame: 15 days before hospitalization
|
they indicate it in meter and centimeters
|
15 days before hospitalization
|
complementary informations: sleeping hours
Time Frame: 15 days before hospitalization
|
they indicate it in number of sleeping hours for each night
|
15 days before hospitalization
|
complementary informations: alcohol consumption
Time Frame: 15 days before hospitalization
|
2 propositions: YES or NO
|
15 days before hospitalization
|
complementary informations: cigarette consumption
Time Frame: 15 days before hospitalization
|
2 propositions: YES or NO
|
15 days before hospitalization
|
complementary informations: physical activity
Time Frame: 15 days before hospitalization
|
2 propositions: YES or NO
|
15 days before hospitalization
|
complementary informations: artistic activity
Time Frame: 15 days before hospitalization
|
2 propositions: YES or NO
|
15 days before hospitalization
|
complementary informations: dietary regime
Time Frame: 15 days before hospitalization
|
2 propositions: YES or NO
|
15 days before hospitalization
|
Physical health informations (PROMISE database)
Time Frame: 7 months after hospitalization
|
All these informations are extracted from PROMISE database : type and stage of hemopathy, type of conditioning (myeloablative, non-myeloablative).
During follow-up, transplant intake, acute and chronic GvHD, infections, number of days in hospital, relapse and death (and cause)
|
7 months after hospitalization
|
Collaborators and Investigators
Investigators
- Principal Investigator: Régis Peffault De Latour, Pr., Saint-Louis Hospital, Paris, France
Publications and helpful links
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Other Study ID Numbers
- AGRAH1
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
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