- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03926104
BNP and Vascular Surgery (BNPinVasc)
Evaluation of BNP Values in Major Vascular Surgery
Background and rationale of the study:
Patients undergoing non-cardiac major surgery show a perioperative cardiac risk and postoperative complications, that can be stratified based on parameters linked to patient's conditions and to surgery types.
An accurate identification of this risk could offer numerous advantages for these patients, who's 30-day mortality is around 2%. The identification of the correct risk could lead to a better pre- and postoperative management, that could guarantee a better surgery outcome and a faster postoperative recovery.
To this day there is no perfect method to correctly estimate this risk. Various studies show that high BNP levels are linked to cardiac events at 30 and 180 days. Further investigations identify different groups, at low, intermediate and high risk, based on BNP levels.
BNP is released by ventricular myocytes in response to a wall distress, due to an increased volume, pressure or myocardial ischemia.
So BNP plasma levels could be used as a prognostic and diagnostic marker, improving the cardiac risk stratification in patients undergoing surgery and a much more precise management.
This study is determined to do an evaluation of the correlations between pre- and postoperative BNP levels and the incidence of cardiac events in patients undergoing major vascular surgery.
Study Overview
Status
Detailed Description
Patient's informed consent signature for adhesion at the study will be initially requested. With their acceptance, parameters will be recorded anonymously in the Case Report Form, identified by their initials and a numeric code, until hospital discharge.
The parameters analyzed will be related to:
- preoperative evaluation: anamnesis, health general conditions, METs, preoperative monitoring, in particularly BNP basal levels;
- intraoperative evaluation: intraoperative monitoring;
- postoperative evaluation: BNP and cTnI levels at 24 and 48 hours, and about pulmonary, cardiovascular, neurological and surgical postoperative complications, based on the medical record.
The data will be transferred on Excel worksheet, utilized for descriptive analysis related at every variable.
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Contact
- Name: Elena Giovanna Bignami, MD Professor
- Email: elenagiovanna.bignami@unipr.it
Study Locations
-
-
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Parma, Italy, 43126
- Recruiting
- Elena Giovanna Bignami
-
Contact:
- Elena Giovanna Bignami, MD Professor
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Ability to provide an informed consent
- Age >18 years old
- Elective abdominal aortic aneurysm surgery
Exclusion Criteria:
- Emergency surgery
- Age ˂ 18 years old
- Creatinine >2mg/dl
- Diseases of ascending aorta, aortic arch or thoracic aorta
- Chronic atrial fibrillation
- Patient refusal to provide informed consent
Study Plan
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Prospective
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Incidence of cardiac events
Time Frame: from the induction of general anesthesia until hospital discharge, an average of 1 week
|
from the induction of general anesthesia until hospital discharge, an average of 1 week
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Incidence of postoperative pulmonary complication
Time Frame: from immediately after surgery until hospital discharge, an average of 1 week
|
from immediately after surgery until hospital discharge, an average of 1 week
|
Incidence of postoperative neurological complication
Time Frame: from immediately after surgery until hospital discharge, an average of 1 week
|
from immediately after surgery until hospital discharge, an average of 1 week
|
Incidence of postoperative acute kidney failure
Time Frame: from immediately after surgery until hospital discharge, an average of 1 week
|
from immediately after surgery until hospital discharge, an average of 1 week
|
Incidence of unplanned ICU admission
Time Frame: from immediately after surgery until hospital discharge, an average of 1 week
|
from immediately after surgery until hospital discharge, an average of 1 week
|
Hospital length of stay
Time Frame: from immediately after surgery until hospital discharge, an average of 1 week
|
from immediately after surgery until hospital discharge, an average of 1 week
|
Incidence of mortality
Time Frame: from immediately after surgery until hospital discharge, an average of 1 week
|
from immediately after surgery until hospital discharge, an average of 1 week
|
Collaborators and Investigators
Sponsor
Publications and helpful links
General Publications
- Vetrugno L, Orso D, Matellon C, Giaccalone M, Bove T, Bignami E. The Possible Use of Preoperative Natriuretic Peptides for Discriminating Low Versus Moderate-High Surgical Risk Patient. Semin Cardiothorac Vasc Anesth. 2018 Dec;22(4):395-402. doi: 10.1177/1089253217752061. Epub 2018 Jan 13.
- Wayne Causey M, Singh N. Clinical implications of B-type natriuretic peptide and N-terminal pro--B-type natriuretic peptide in the care of the vascular surgery patient. Semin Vasc Surg. 2014 Dec;27(3-4):143-7. doi: 10.1053/j.semvascsurg.2015.01.004. Epub 2015 Jan 21.
- Biccard BM, Devereaux PJ, Rodseth RN. Cardiac biomarkers in the prediction of risk in the non-cardiac surgery setting. Anaesthesia. 2014 May;69(5):484-93. doi: 10.1111/anae.12635.
- Bryce GJ, Payne CJ, Gibson SC, Byrne DS, Delles C, McClure J, Kingsmore DB. B-type natriuretic peptide predicts postoperative cardiac events and mortality after elective open abdominal aortic aneurysm repair. J Vasc Surg. 2013 Feb;57(2):345-53. doi: 10.1016/j.jvs.2012.07.053. Epub 2012 Oct 9.
- Vetrugno L, Costa MG, Pompei L, Chiarandini P, Drigo D, Bassi F, Gonano N, Muzzi R, Della Rocca G. Prognostic power of pre- and postoperative B-type natriuretic peptide levels in patients undergoing abdominal aortic surgery. J Cardiothorac Vasc Anesth. 2012 Aug;26(4):637-42. doi: 10.1053/j.jvca.2012.01.018. Epub 2012 Mar 2.
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 39751 del 19/10/2018
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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