Observation of Blood Orphanin and Norepinephrine Levels in Diabetic Patients Under Subarachnoid Anesthesia

June 30, 2020 updated by: Zheng Guo, Second Hospital of Shanxi Medical University

Effect of Subarachnoid Anesthesia on Blood Orphanin and Norepinephrine in Diabetic Patients

This study aims to investigate the Influence of Intraspinal anesthesia to the concentrations of blood orphanin, norepinephrine in patients with diabetes mellitus. We hope to explain the relationship between sensory and sympathetic nerves in diabetic patients undergoing intraspinal anesthesia.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Actual)

120

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • China
    • Shanxi
      • Taiyuan, Shanxi, China, 030001
        • Second of Shanxi Medical University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 75 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

primary care clinic

Description

Inclusion Criteria:

  • Patients undergoing lower limb surgery under spinal anesthesia

Exclusion Criteria:

  • Emergency surgery
  • The operation time is more than 3 hours
  • Combined general anesthesia or nerve block anesthesia

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Diabetes mellitus group
Diabetic patients undergoing spinal anesthesia for lower extremity surgery
Diagnostic test: ELISA
Detection of blood orphanin and norepinephrine in patients
Non-diabetic group
Non-diabetic patients undergoing spinal anesthesia for lower extremity surgery
Diagnostic test: ELISA
Detection of blood orphanin and norepinephrine in patients

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Blood orphanin concentration
Time Frame: 24 hours
Concentration of blood orphanin in patients before and after anesthesia
24 hours
Blood norepinephrine concentration
Time Frame: 24 hours
Concentration of blood norepinephrine in patients before and after anesthesia
24 hours

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Second Hospital of Shanxi Medical University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

October 1, 2019

Primary Completion (Actual)

April 2, 2020

Study Completion (Actual)

June 1, 2020

Study Registration Dates

First Submitted

August 26, 2019

First Submitted That Met QC Criteria

August 26, 2019

First Posted (Actual)

August 28, 2019

Study Record Updates

Last Update Posted (Actual)

July 2, 2020

Last Update Submitted That Met QC Criteria

June 30, 2020

Last Verified

June 1, 2020

More Information

Terms related to this study

Other Study ID Numbers

  • hanyi20190826

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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