- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04083482
Removal of mtDNA in Plasma by Continous Venovenous Hemofiltration in Sepsis
September 5, 2019 updated by: Xingui Dai, First People's Hospital of Chenzhou
The plasma level of mtDNA in sepsis is affected by continous venovenous hemofiltation(CVVH)
Study Overview
Status
Unknown
Conditions
Intervention / Treatment
Detailed Description
Continous renal replacement therapy (CRRT)has become routine for patients with chronic renal failure ,AKI,fliud overload as well as oliguria in ICU .In clinical patients ,continous venovenous hemofoiltration (CVVH)is actually the method of chioce for CRRT in critically ill and hemodynamic instable patients .CVVH has significant beneficial effects on removing inflammatory cytokines ,improving oxygen index,increasing cardiac index and regulating immune dysfuntion .
Study Type
Interventional
Enrollment (Actual)
20
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Hunan
-
Chenzhou, Hunan, China, 450003
- The First Hospital of Chenzhou
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
Adult septic patients undergoing CRRT
Exclusion Criteria:
- Missing vists
- transplatation
- cancer
- aquired immunodeficiency syndrome
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Septic patients require CVVH
continuous venovenous hemofiltration.
Continuous renal replacement therapy(CRRT)has become routine for patients with chronic renal failure ,AKI,fliud overload as well as oliguria in ICU .Continuous venovenous hemofiltration(CVVH)is the method of chioce for CRRT in critical ill .CVVH has significant beneficial effects on removing inflammatory cytokines ,improving oxygen index ,decreasing vasopressor requirements,increasing cardiac index and regulating immune dysfunction .
|
CVVH
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change of mtDNA concentration in plasma
Time Frame: befor,6hours, 12hours, after CVVH treatment
|
The specimens in the prefilter and postfilter blood as well as in the ultrafiltrate were obtained at the beginning of CRRT (T0) and 6 h (T6h), 12 h (T12h) after the setup of CVVH.
|
befor,6hours, 12hours, after CVVH treatment
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Study Director: dixian luo, MS, Chenzhou First People Hospital
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
August 20, 2018
Primary Completion (Actual)
September 20, 2018
Study Completion (Anticipated)
December 31, 2019
Study Registration Dates
First Submitted
September 3, 2019
First Submitted That Met QC Criteria
September 5, 2019
First Posted (Actual)
September 10, 2019
Study Record Updates
Last Update Posted (Actual)
September 10, 2019
Last Update Submitted That Met QC Criteria
September 5, 2019
Last Verified
September 1, 2019
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- WYJ2019
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Intensive Care Unit
-
University of MelbourneEnrolling by invitationICU Acquired Weakness | Intensive Care Unit Syndrome | Intensive Care Unit Acquired Weakness | Post Intensive Care Unit Syndrome | Post Intensive Care SyndromeAustralia
-
Seoul National University HospitalMinistry of Food and Drug Safety, KoreaCompletedPostoperative Care | Intensive Care UnitKorea, Republic of
-
Centre Hospitalier Régional d'OrléansRecruiting
-
Nantes University HospitalRecruiting
-
Mayo ClinicCompletedPalliative Care | Intensive Care Unit | HospiceUnited States
-
First People's Hospital of ChenzhouRecruiting
-
Hospira, now a wholly owned subsidiary of PfizerCompleted
-
Hospital Israelita Albert EinsteinActive, not recruitingCritical Care | Intensive Care UnitBrazil
-
Hospices Civils de LyonCompletedPediatric Intensive Care UnitFrance, Belgium, Lebanon, Switzerland
-
Taipei Veterans General Hospital, TaiwanCompletedIntensive Care Unit PatientsTaiwan
Clinical Trials on continous venovenous hemofiltraion
-
Onze Lieve Vrouwe GasthuisCompletedAcute Renal Failure | Multiple Organ Failure | KidneyNetherlands
-
Hopital LariboisièreMinistry of Health, FranceCompletedSepsis | Gram-Negative Bacterial Infections | Gram-Positive Bacterial Infections | Shock, Septic | Bacteremia | Pneumonia, BacterialFrance
-
Australian and New Zealand Intensive Care Research...The AlfredNot yet recruitingPneumonia | Extracorporeal Membrane Oxygenation | Mechanical Ventilation Complication | Hypoxemia | COVID-19 Respiratory Infection | Acute Respiratory Distress Syndrome Due to COVID-19Australia, Germany
-
University of TorontoUniversity Health Network, TorontoNot yet recruitingARDSCanada, United States
-
University of ChicagoNxStage MedicalCompletedAcute Renal FailureUnited States
-
University of MichiganCompletedRespiratory FailureUnited States
-
University Hospital, BordeauxMinistry of Health, FranceCompletedShock, Septic | Renal Failure, AcuteFrance, Belgium, Netherlands
-
Qingdao UniversityCompleted
-
William Beaumont HospitalsCompletedAsthma in Children | Respiratory Disease | Bronchiolitis Acute | Pneumonia in ChildrenUnited States
-
The University of Texas Medical Branch, GalvestonTerminatedPulmonary Disease, Chronic ObstructiveUnited States