Neuromuscular Ultrasound in Correlation to Neurophysiological Findings

September 17, 2019 updated by: Shahera Sayed Ahmed Abd El Maged, Assiut University

Neuromuscular Ultrasound Changes in Neuropathies in Correlation to Neurophysiological Findings

  1. Study the neuromuscular ultrasound findings in different types of neuropathies
  2. correlation between ultrasound and neurophysiological findings in peripheral nerve diseases
  3. correlation between clinical pain scale and severity of neuropathy

Study Overview

Detailed Description

Ultrasonography is a diagnostic tool that is increasingly used in the work-up of peripheral nerve disease.

As many peripheral nerves run a superficial course, especially in the arms. This is a big advantage over Magnetic Resonance Imaging that is relatively expensive, time consuming and not readily available everywhere.

Nerve cross-sectional area (CSA) can be determined at multiple sites along the nerve.

CSA can be measured at entrapment sites but also at nonentrapment sites. vascularization, echogenicity, fascicular pattern and endoneurial thickness can be investigated as well. All those modalities can give critical insight in the origin and development of various peripheral neuropathies1,2,3

Major peripheral nerves in the extremities, such as the median,ulnar thick enough to reflect the sound beam, resulting in hyperechoic on the US scan 4.

The correlation between nerve conduction study parameters and CSA in ultrasound Ultrasound of the peripheral nervous system is an additional useful diagnostic tool in neuromuscular disorders..5,6,7,8,9 In the longitudinal plane, nerves present as long, slim structures with a mixture of parallel hypoechoic and hyperechoic lines.

Nerves must be distinguished from other nearby structures to ensure correct identification Muscles are hypoechoic and interspersed with small hyperechoic foci which easily distinguishes muscles from nerves. Tendons, which are sometimes adjacent to nerves, move proportionately with joint movement.

US has higher specificity than sensitivity in differentiating myopathic and neuropathic changes The most sensitive diagnostic marker for symptomatic carpal tunnel syndrome patients is an enlarged crosssectional area of the median nerve 10,11,12

Study Type

Observational

Enrollment (Anticipated)

100

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 70 years (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Sampling Method

Probability Sample

Study Population

Setting:in assuit university hospitals, neuropsychiatry hospital,neurology, orthopedic ,and internal medicine outpatients clinics subjects:will include two groups : peripheral nerve diseases group and healthy control group

Description

Inclusion Criteria:

  • above 18 years old
  • males or females
  • diabetic complaining of neuropathy or not
  • carpal tunnel syndrome
  • Guillain-Barré syndrome

Exclusion Criteria:

  • Patient refuse to participate
  • The anatomy is altered due to sever trauma,tumor,or surgery
  • Severe spasticity preventing examination

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
diabetic complaining of neuropathy or not
using of ultrasound in examination and nerve conduction study
easy new non invasive tool
Other Names:
  • ultrasonography
carpal tunnel syndrome
using of ultrasound in examination and nerve conduction study
easy new non invasive tool
Other Names:
  • ultrasonography

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Nerve ultrasound
Time Frame: 3 years
on median and ulnar nerves
3 years
muscle Ultrasound
Time Frame: 3 years
on thenar and hypothenar muscles
3 years
nerve conduction studies
Time Frame: 3 years
for median and ulnar nerves (sensory and motor)
3 years
Electromyogram
Time Frame: 3 years
for thenar and hypothenar
3 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Anticipated)

October 1, 2019

Primary Completion (Anticipated)

October 1, 2022

Study Completion (Anticipated)

November 1, 2022

Study Registration Dates

First Submitted

September 14, 2019

First Submitted That Met QC Criteria

September 14, 2019

First Posted (Actual)

September 17, 2019

Study Record Updates

Last Update Posted (Actual)

September 19, 2019

Last Update Submitted That Met QC Criteria

September 17, 2019

Last Verified

September 1, 2019

More Information

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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