- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04092140
Neuromuscular Ultrasound in Correlation to Neurophysiological Findings
Neuromuscular Ultrasound Changes in Neuropathies in Correlation to Neurophysiological Findings
- Study the neuromuscular ultrasound findings in different types of neuropathies
- correlation between ultrasound and neurophysiological findings in peripheral nerve diseases
- correlation between clinical pain scale and severity of neuropathy
Study Overview
Status
Intervention / Treatment
Detailed Description
Ultrasonography is a diagnostic tool that is increasingly used in the work-up of peripheral nerve disease.
As many peripheral nerves run a superficial course, especially in the arms. This is a big advantage over Magnetic Resonance Imaging that is relatively expensive, time consuming and not readily available everywhere.
Nerve cross-sectional area (CSA) can be determined at multiple sites along the nerve.
CSA can be measured at entrapment sites but also at nonentrapment sites. vascularization, echogenicity, fascicular pattern and endoneurial thickness can be investigated as well. All those modalities can give critical insight in the origin and development of various peripheral neuropathies1,2,3
Major peripheral nerves in the extremities, such as the median,ulnar thick enough to reflect the sound beam, resulting in hyperechoic on the US scan 4.
The correlation between nerve conduction study parameters and CSA in ultrasound Ultrasound of the peripheral nervous system is an additional useful diagnostic tool in neuromuscular disorders..5,6,7,8,9 In the longitudinal plane, nerves present as long, slim structures with a mixture of parallel hypoechoic and hyperechoic lines.
Nerves must be distinguished from other nearby structures to ensure correct identification Muscles are hypoechoic and interspersed with small hyperechoic foci which easily distinguishes muscles from nerves. Tendons, which are sometimes adjacent to nerves, move proportionately with joint movement.
US has higher specificity than sensitivity in differentiating myopathic and neuropathic changes The most sensitive diagnostic marker for symptomatic carpal tunnel syndrome patients is an enlarged crosssectional area of the median nerve 10,11,12
Study Type
Enrollment (Anticipated)
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- above 18 years old
- males or females
- diabetic complaining of neuropathy or not
- carpal tunnel syndrome
- Guillain-Barré syndrome
Exclusion Criteria:
- Patient refuse to participate
- The anatomy is altered due to sever trauma,tumor,or surgery
- Severe spasticity preventing examination
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
diabetic complaining of neuropathy or not
using of ultrasound in examination and nerve conduction study
|
easy new non invasive tool
Other Names:
|
carpal tunnel syndrome
using of ultrasound in examination and nerve conduction study
|
easy new non invasive tool
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Nerve ultrasound
Time Frame: 3 years
|
on median and ulnar nerves
|
3 years
|
muscle Ultrasound
Time Frame: 3 years
|
on thenar and hypothenar muscles
|
3 years
|
nerve conduction studies
Time Frame: 3 years
|
for median and ulnar nerves (sensory and motor)
|
3 years
|
Electromyogram
Time Frame: 3 years
|
for thenar and hypothenar
|
3 years
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start (Anticipated)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Pathologic Processes
- Nervous System Diseases
- Immune System Diseases
- Autoimmune Diseases of the Nervous System
- Demyelinating Diseases
- Autoimmune Diseases
- Wounds and Injuries
- Endocrine System Diseases
- Disease
- Diabetes Complications
- Diabetes Mellitus
- Neuromuscular Diseases
- Mononeuropathies
- Peripheral Nervous System Diseases
- Median Neuropathy
- Nerve Compression Syndromes
- Cumulative Trauma Disorders
- Sprains and Strains
- Polyradiculoneuropathy
- Polyneuropathies
- Syndrome
- Carpal Tunnel Syndrome
- Diabetic Neuropathies
- Guillain-Barre Syndrome
Other Study ID Numbers
- ultrasound in neuropathies
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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