the Association Between Obesity and Early Puberty

March 18, 2020 updated by: Di Li, Shenzhen Center for Disease Control and Prevention

Polymorphisms in Obesity-related Genes Are Associated With Risk of Early Puberty in Han Chinese Girls

childhood obesity and early puberty are closely related, but existing reports usually focus on their relationship from the perspective of phenotype. This study was designed to investigate the association between obesity-related genic polymorphisms and the risk of early puberty in Chinese Han girls.

Study Overview

Status

Completed

Conditions

Detailed Description

the genotypes of obesity-related SNPs were determined and the unstimulated luteinizing hormone, follicle stimulating hormone and estradiol levels were also detected.

Study Type

Observational

Enrollment (Actual)

628

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

7 years to 10 years (Child)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

Female

Sampling Method

Probability Sample

Study Population

Chinese Han girls from Shenzhen Children's Hospital or monitoring schools in Shenzhen

Description

Inclusion Criteria:

  • Clinical diagnosis of central precocious puberty or early and fast puberty.

Exclusion Criteria:

  • The participants who were not the first visit to the hospital and had been treated before.
  • The participants who were with endocrine disorders.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
cases
early puberty girls of Han Chinese
controls
normal development girls of Han Chinese

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
genotypes of SNPs in the obesity-related genes
Time Frame: 3 months
the obesity-related SNPs in the LRRN6C, MAF, CYP27A1 and ETV5 genes are selected and the genotypes of these SNPs are determined with a MassARRAY system.
3 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Shenzhen Center for Disease Control and Prevention

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

September 1, 2016

Primary Completion (Actual)

May 20, 2018

Study Completion (Actual)

June 4, 2019

Study Registration Dates

First Submitted

March 17, 2020

First Submitted That Met QC Criteria

March 18, 2020

First Posted (Actual)

March 20, 2020

Study Record Updates

Last Update Posted (Actual)

March 20, 2020

Last Update Submitted That Met QC Criteria

March 18, 2020

Last Verified

March 1, 2020

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • szCDC_2

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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