- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04541342
Arthroscopic Evaluation of Cartilage Regeneration After Opening-wedge High Tibial Osteotomy
Second-look Arthroscopic Evaluation of Cartilage Regeneration After Medial Opening-wedge High Tibial Osteotomy
Study Overview
Status
Conditions
Detailed Description
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Ahmed Mohamed, Bachelor
- Phone Number: +201064986480
- Email: am.sayed.94@gmail.com
Study Contact Backup
- Name: Ayman Farouk, MD
- Phone Number: +201005460273
- Email: aymanfaaa@aun.edu.eg
Study Locations
-
-
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Assiut, Egypt
- Recruiting
- Assiut university hospitals
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Assiut, Egypt
- Recruiting
- AssiutU Hospitals
-
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Age younger than 65 years
- Medial joint line tenderness
- BMI less than 30
- Varus tibiofemoral malalignment
- Range of motion in the knee joint maintained from greater than 100 degrees of flexion to less than 15 degrees of flexion contracture
- Osteoarthritis of the knee with any degree of cartilage damage provided that the cartilage damage in the lateral compartment not exceeding Outerbridge grade 2
- No associated ligamentous functional instability
Exclusion Criteria:
- Age older than 65 years
- Severe Lateral compartment osteoarthritis (Outerbridge grade 3 or 4)
- Flexion contracture of greater than 15 degrees
- Inflammatory arthritis, post-traumatic osteoarthritis, active knee infection
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: osteoarthritic with genu varus
initial arthroscopy and high tibial osteotomy to be followed later by a second look arthroscopy with plate removal
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It is a joint preserving procedure especially preferred in young patients for whom arthroplasty is not desirable.
The procedure promotes regeneration by causing lateral shift of the weight-bearing axis, thus decreasing load on the medial compartment and widening the medial joint space.Many of the patients complains of irritation through the plate and wish metal removal after healing of the osteotomy.All patients will undergo initial arthroscopy before high tibial osteotomy (HTO).
During arthroscopy, debridement of the degenerate tissues and meniscal tears if present will be performed.
Then opening-wedge high tibial osteotomy (OWHTO) will be performed and fixed by a plate system.
Second-look arthroscopy will be conducted at the time of plate removal after healing of the osteotomy.
This will be after about 6 months up to one year.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Arthroscopic assessment of cartilage regeneration after high tibial osteotomy
Time Frame: 6 months after high tibial osteotomy
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By use of Outerbridge classification of chondral lesions during arthroscopy, comparison will be made between cartilage status before and after high tibial osteotomy according to the Outerbrigde classification which classifies cartilage lesions into grades of 0 through IV. Grade 0 signifies normal cartilage. Grade I chondral lesions are characterized by softening and swelling, which often require tactile feedback with a probe or other instrument to assess. Grade II lesion describes a partial-thickness defect with fissures that do not exceed 0.5 inches in diameter or reach subchondral bone. Grade III is fissuring of the cartilage with a diameter > 0.5 inches with an area reaching subchondral bone. The most severe is Grade IV, which includes erosion of the articular cartilage that exposes subchondral bone. |
6 months after high tibial osteotomy
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Post-operative limb alignment
Time Frame: 6 months after high tibial osteotomy
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by use of bilateral standing anteroposterior full-length views of both lower limbs before high tibial osteotomy and at time of plate removal.
The tibiofemoral angle will be measured to detect the degree of varus correction.
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6 months after high tibial osteotomy
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Collaborators and Investigators
Sponsor
Publications and helpful links
General Publications
- Kim KI, Seo MC, Song SJ, Bae DK, Kim DH, Lee SH. Change of Chondral Lesions and Predictive Factors After Medial Open-Wedge High Tibial Osteotomy With a Locked Plate System. Am J Sports Med. 2017 Jun;45(7):1615-1621. doi: 10.1177/0363546517694864. Epub 2017 Mar 14.
- Slattery C, Kweon CY. Classifications in Brief: Outerbridge Classification of Chondral Lesions. Clin Orthop Relat Res. 2018 Oct;476(10):2101-2104. doi: 10.1007/s11999.0000000000000255. No abstract available.
- Koshino T, Wada S, Ara Y, Saito T. Regeneration of degenerated articular cartilage after high tibial valgus osteotomy for medial compartmental osteoarthritis of the knee. Knee. 2003 Sep;10(3):229-36. doi: 10.1016/s0968-0160(03)00005-x.
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- arthroscopy with HTO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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