Effect of Lighting Supplementation on Daytime Cognition

The Effect of Lighting Supplementation on Cognitive Task Performance During the Day

The aim of the study is to examine the efficacy of supplementing sub-optimal ambient room lighting with a task lamp on working memory and procedural learning.

Study Overview

• Status: Active, not recruiting
• Conditions: Non-visual Effects of Light
• Intervention / Treatment: Device: Visible light

• Study Type: Interventional
• Enrollment (Anticipated): 16
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • Massachusetts
    • Boston, Massachusetts, United States, 02115
      • Brigham and Women's Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 30 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Aged between 18-30 years;
• Healthy (no medical, psychiatric or sleep disorders;
• Non-smoking for at least 6 months;
• Body Mass Index of >18 or <30 kg/m2;
• Able to maintain 7-hour consistent sleep schedule during the study
• Able to refrain from caffeine, alcohol, medication and supplements during the study

Exclusion Criteria:

• History of alcohol or substance abuse;
• positive result on drugs of abuse urine toxicology;
• Current or past history of sleep disorders, including but not limited to obstructive sleep apnea, narcolepsy, insomnia, or any significant sleep complaint
• Psychiatric disorder, or first degree relative with a psychiatric disorder
• Recent acute or chronic medical disorder
• Use of drugs or medication (birth control OK) likely to affect sleep, alertness or light sensitivity, as determined by the investigators
• Visual disorder, including but not limited to color blindness, or family history of glaucoma
• Pregnancy or lactation
• Shift work (> 2 nights / week in the last 3 months and not during the study)
• Transmeridian travel (2 or more time zones) in the past 3 months
• Any other reason as determine by the Principal Investigator

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: Ambient light; Fluorescent ambient lighting	Device: Visible light; Ambient room lighting will be supplemented with additional light from a task lamp.
Experimental: Ambient light plus task lamp; Fluorescent ambient lighting plus task lamp	Device: Visible light; Ambient room lighting will be supplemented with additional light from a task lamp.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Working memory	Percent correct responses on a 2-minute mental arithmetic task	8 hour light exposure

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Procedural learning	Percent change in the number of correct sequences on the Motor Sequence Task	8 hour light exposure

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
Vigilance	Reaction time and lapses on the Psychomotor Vigilance Task	8 hour light exposure
Subjective sleepiness	Subjective sleepiness assessed by the Karolinska Sleepiness Scale - Scale from 1-9 where higher scores indicate greater sleepiness	8 hour light exposure
Memory recall	Percentage of correctly recalled words on a paired associates task	8 hour light exposure
Psychological distress	Total score on the Profile of Mood States (POMS)	8 hour light exposure
Affect	Positive and negative affect scores assessed by the PANAS	8 hour light exposure

Collaborators and Investigators

• Sponsor: Brigham and Women's Hospital
• Investigators: Principal Investigator: Shadab A Rahman, PhD, MPH, Brigham and Women's Hospital

Study record dates

Study Major Dates

• Study Start (Actual): March 1, 2021
• Primary Completion (Anticipated): March 1, 2022
• Study Completion (Anticipated): March 1, 2022

Study Registration Dates

• First Submitted: February 4, 2021
• First Submitted That Met QC Criteria: February 4, 2021
• First Posted (Actual): February 9, 2021

Study Record Updates

• Last Update Posted (Actual): February 18, 2022
• Last Update Submitted That Met QC Criteria: February 16, 2022
• Last Verified: February 1, 2022

More Information

Terms related to this study

• Keywords: Cognition; Learning; Light; Alertness
• Other Study ID Numbers: 2019P000900; 2020A011565 (Other Grant/Funding Number: Biological Innovation and Optimization Systems, LLC.)

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No