Biomarkers of Chronic Obstructive Pulmonary Disease (BIOBPCO)

August 22, 2023 updated by: Centre Hospitalier Universitaire, Amiens

Specific Biomarker Identification of Different Subgroups of Chronic Obstructive Pulmonary Disease

There are few studies about immunological explorations in COPD. Because of the complications of lung biopsies, analyses are generally made on blood samples instead of lung tissue. No study tried to classify COPD vs Asthma vs ACOS. The investigators wondered if there were differences in biomarkers between these groups. The investigators decided to open a pilot-study among COPD patients followed in Amiens-University Hospital. Each patient will be examined and a blood-test will be performed.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Actual)

75

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

Study Locations

  • France
      • Amiens, France, 80480
        • CHU Amiens

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

chronic obstructive pulmonary disease (COPD) patients, followed in Amiens-University Hospital

Description

Inclusion Criteria:

  • BPCO patients
  • ACOS patients
  • asthmatic patient without BPCO

Exclusion Criteria:

  • infection
  • exacerbation
  • immunosuppressive treatment
  • immunosuppressive disease

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
frequent exacerbation patients
Other: Physical examinations
BPCO physical examinations
Diagnostic test: blood test
blood test in order to study immunologic markers
non frequent exacerbation patients
Other: Physical examinations
BPCO physical examinations
Diagnostic test: blood test
blood test in order to study immunologic markers
Asthma-and-COPD overlap syndrome
Other: Physical examinations
BPCO physical examinations
Diagnostic test: blood test
blood test in order to study immunologic markers
Asthmatic patients (without COPD)
Other: Physical examinations
BPCO physical examinations
Diagnostic test: blood test
blood test in order to study immunologic markers

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
identification specific blood immunologic marker for COPD
Time Frame: one hour
COPD biomarkers are blood immunologic markers
one hour

Secondary Outcome Measures

Outcome Measure
Time Frame
Complete blood count (CBC) Variation between COPD and asthmatic patients
Time Frame: one hour
one hour
c-reactive protein concentration variation between COPD and asthmatic patients
Time Frame: one hour
one hour
Plasma protein electrophoresis profile Variation between COPD and asthmatic patients
Time Frame: one hour
one hour

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Centre Hospitalier Universitaire, Amiens

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

June 15, 2021

Primary Completion (Actual)

July 1, 2023

Study Completion (Actual)

July 1, 2023

Study Registration Dates

First Submitted

June 17, 2021

First Submitted That Met QC Criteria

July 5, 2021

First Posted (Actual)

July 15, 2021

Study Record Updates

Last Update Posted (Actual)

August 23, 2023

Last Update Submitted That Met QC Criteria

August 22, 2023

Last Verified

August 1, 2023

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • PI2021_843_0051

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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