COVID-19 and Vitamin D: Length of Hospital Stay and Mortality

Vitamin D Level: Reflections of a Public Health Issue in the COVID-19 Pandemic. Does it Affect Mortality and Length of Hospital Stay?

The lack of a pharmacological treatment in the COVID-19 pandemic has pushed scientists to search for this issue. Maintaining optimal health is parallel to adequate and balanced nutrition. In this context, can the protective properties of vitamin D play an important role in this pandemic? brought with it the thought. In this study, it was aimed to examine the effect of vitamin D on mortality and hospital stay in COVID-19 disease.

Study Overview

• Status: Completed
• Conditions: Vitamin D Deficiency; COVID-19 Pandemic

Detailed Description

This research was conducted to examine the effect of vitamin D on mortality and hospital stay in COVID-19 disease. For this, the approval of the Ministry of Health and then the ethics committee was obtained. For this reason, patients with positive PCR tests and hospitalized patients with vitamin D levels in their biochemistry were included in the study.

The data of the patients were obtained from the medical records. Information such as age, gender, comorbidities, length of hospital stay, vitamin D level were included in the study. According to the statistical analyzes obtained from these data, it has been shown that vitamin D level has no effect on mortality and hospital stay in COVID-19 disease.

• Study Type: Observational
• Enrollment (Actual): 168

Contacts and Locations

Study Locations

• Turkey
  • Ankara, Turkey, 06800
    • Republic of Turkey Ministry of Health Ankara City Hospitals Neurology-Orthopedics Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

Adult patients with positive COVID-19 PCR (Polymerase Chain Reaction) test and vitamin D level in biochemical parameters, who applied to Ankara City Hospital Neurology-Orthopedics Hospital between 01 August and 31 October 2020.

Description

Inclusion Criteria:

• COVID-19 PCR (Polymerase Chain Reaction) test positive
• Vitamin D level in biochemical parameters
• Adult patients hospitalized for COVID-19

Exclusion Criteria:

-Patients using drugs that may affect vitamin D absorption, such as corticosteroids, cholesterol-lowering agents, phenobarbital and phenytoin-containing agents

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
Patients with COVID-19 + with vitamin D levels; Patients with COVID-19 + and vitamin D levels were included in the study retrospectively. Vitamin D level was categorized into 3 groups as inadequacy, deficiency and normal from medical records. No intervention was made.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Level of Vitamin D	Vitamin D levels of patients with a diagnosis of COVID-10. These results were categorized at the level of deficiency/insufficiency/normal.	1 month later
Relationship between vitamin D level and mortality	Relationship between survival and death by categorized vitamin D level.	1 month later
Relationship between vitamin D level and hospital stay	Length of hospital stay by categorized vitamin D level.	1 month later

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Effects of additional diseases (Diabetes mellitus, hypertension, etc.) on hospital stay and mortality	Evaluation of the impact of comorbidities on survival during COVID-19 disease.	1 month later.

Collaborators and Investigators

• Sponsor: Yuksek Ihtisas University
• Collaborators: Ankara City Hospital Bilkent
• Investigators: Study Director: Levent Öztürk, MD, Republic of Turkey Ministry of Health Ankara City Hospitals Neurology-Orthopedics Hospital

Study record dates

Study Major Dates

• Study Start (Actual): August 21, 2021
• Primary Completion (Actual): November 9, 2021
• Study Completion (Actual): November 16, 2021

Study Registration Dates

• First Submitted: February 2, 2022
• First Submitted That Met QC Criteria: February 2, 2022
• First Posted (Actual): February 3, 2022

Study Record Updates

• Last Update Posted (Actual): February 21, 2022
• Last Update Submitted That Met QC Criteria: February 3, 2022
• Last Verified: February 1, 2022

More Information

Terms related to this study

• Keywords: Vitamin D; COVID-19; Mortality; Length of stay
• Additional Relevant MeSH Terms: Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Virus Diseases; Infections; Respiratory Tract Infections; Respiratory Tract Diseases; Pneumonia, Viral; Pneumonia; Lung Diseases; Nutrition Disorders; Avitaminosis; Deficiency Diseases; Malnutrition; COVID-19; Vitamin D Deficiency
• Other Study ID Numbers: YuksekIU-SCOZBEK001

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No