Cutaneous Squamous Cell Carcinoma Staging Study

April 1, 2026 updated by: Queen Mary University of London

Comparison of the Prognostic Capacity of Existing Staging Systems for Cutaneous Squamous Cell Carcinoma

Cutaneous squamous cell carcinoma (CSCC) is the second most common form of skin cancer, and one of the most common cancers worldwide. The majority of CSCCs are easily removed by surgery and have excellent prognosis. However, a small subset has poor outcomes, including secondary spread in the body (metastasis) and death.

The investigators will look at existing CSCC in people from two UK dermatology centres. The investigators will then evaluate the accuracy of current staging systems in predicting risk of poor outcomes in people. The investigators hope that this project will improve the management of patients with CSCC by validating the predictive power of currently available histological staging classifications for cSCC. In the second stage of the study, The investigators will see whether better prediction tools can be found.

Study Overview

Status

Recruiting

Conditions

Cutaneous Squamous Cell Carcinoma

Intervention / Treatment

Other: This is not an interventional study

Study Type

Observational

Enrollment (Estimated)

1500

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

United Kingdom
- - London, United Kingdom, E11 1NR
    - Recruiting
    - Whipps Cross University Hospital
    - Contact:
      
      Catherine Harwood
      
      Phone Number: 020 8539 5522
      
      Email: catherine.harwood1@nhs.net
  - London, United Kingdom
    - Active, not recruiting
    - Dr Emilia Peleva

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 120 years (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Sampling Method

Non-Probability Sample

Study Population

Patients treated at two tertiary Dermatology centers

Description

Inclusion Criteria:

Over 18 years old with diagnosis of CSCC

Exclusion Criteria:

Patients who decline for their data to be used for research purposes

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Observational Models: Cohort
Time Perspectives: Retrospective

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Recurrence or metastasis Time Frame: 4 years	Proportion of patients developing cutaneous squamous cell carcinoma locoregional recurrence, nodal or distant metastases	4 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Queen Mary University of London

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

May 1, 2023

Primary Completion (Estimated)

June 5, 2028

Study Completion (Estimated)

June 5, 2028

Study Registration Dates

First Submitted

December 22, 2022

First Submitted That Met QC Criteria

January 20, 2023

First Posted (Actual)

January 23, 2023

Study Record Updates

Last Update Posted (Actual)

April 2, 2026

Last Update Submitted That Met QC Criteria

April 1, 2026

Last Verified