Craniofacial Morphology And Sella Turcica Bridging Associated With Third Molar Agenesis.

Third Molar Agenesis Related To Craniofacial Pattern And Sella Turcica Bridging: A Retrospective Cephalometric Study

The aim of this retrospective study is to analyze the third molar agenesis with respect to sella turcica bridging and other craniofacial patterns in patients asking for orthodontic consultation. The main question[s] it aims to answer are:

• is there a relationship between third molar agenesis and sella turchina bridging?
• is there a relationship between third molar agenesis and craniofacial patterns?

Study Overview

• Status: Completed
• Conditions: Tooth Agenesis
• Intervention / Treatment: Diagnostic test: Radiographic evaluation

Detailed Description

Patients referring for orthodontic consultation at the Unit of Orthodontics and Pediatric Dentistry, Section of Dentistry, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy, will be enrolled for the study according to the inclusion criteria. For each patient, lateral cephalometric radiograph and panoramic radiograph will be performed. For each lateral cephalometric radiograph, a cephalometric tracing will be performed with DeltaDent software (version 2.5.12, Outside Format, Pandino, Italy). Riedel's ANB angle [Riedel 1952] has been chosen to determine patients' skeletal class. Steiner's SN^GoGn angle [Steiner 1953] has been chosen to evaluate skeletal divergence. Facial axis (BaNa^CCGn), Lower Facial Height (LFH) and mandibular plan angle (FH^GoMe) from Rickett's analysis [Rickett's 1961] have been adopted to determine facial growth. According to Jaraback's cephalometric analysis [Jaraback 1985], saddle angle, articular angle, upper gonial angle, lower gonial angle will be measured to assess the growth pattern. Linear measurements of sella depth, sella diameter and interclinoid distance [Silverman 1957; Kisling 1966] will be calculated. Linear regressions between craniofacial patterns, sella turcica bridging and third molar agenesis will be calculated. A control group with no third molar agenesis will be provided.

• Study Type: Observational
• Enrollment (Actual): 400

Contacts and Locations

Study Locations

• Italy
  • Lombardy
    • Pavia, Lombardy, Italy, 27100
      • Unit of Orthodontics and Pediatric Dentistry - Section of Dentistry - Department of Clinical, Surgical, Diagnostic and Pediatrics - University of Pavia

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 9 years to 18 years (Child, Adult)
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Patients referring to the Unit of Orthodontics and Pediatric Dentistry for orthodontic consultation.

Description

Inclusion Criteria:

• G stage of Demirjian's classification for third molar maturation or absence of third molar germs
• Patients with one lateral cephalometric digital radiograph executed in Natural Head Position (patients were asked to keep the teeth in contact and the lips relaxed).
• Patients with panoramic radiograph;

Exclusion Criteria:

• Ascertained previous surgical extraction/s of third molar/s
• Orthopedic/orthodontic therapy
• Orthognathic surgery.

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Case group; Patients with third molar agenesis.	Diagnostic test: Radiographic evaluation; Panoramic and lateral cephalometric radiographs with cephalometric analysis will be performed.
Control group; Patients with the presence of all third molars.	Diagnostic test: Radiographic evaluation; Panoramic and lateral cephalometric radiographs with cephalometric analysis will be performed.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Linear regression between third molar agenesis and ANB	ANB is calculated according to Riedel's analysis: angle formed between Point A (maxillary sovraspinal point), point B (Bubmental mandibular point) and N (Nasion)	Baseline
Linear regression between third molar agenesis and Interclinoid Distance	Distance between tuberculum sella (TS) and dorsum sella (DS).	Baseline
Linear regression between third molar agenesis and Sella Depth.	Distance of a line dropped perpendicular from the interclinoid distance to the deepest point of the sella floor.	Baseline
Linear regression between third molar agenesis and Sella Diameter	Distance between tuberculum sella and the farthest point on the inner wall of the sella.	Baseline
Linear regression between third molar agenesis and Sn^GoGn.	Steiner's Sn^GoGn is the angle formed between 2 planes: cranial base line (SN) and mandibular plane (GoGn)	Baseline
Linear regression between third molar agenesis and ArGo^GoGn	Jaraback's Ar^Go^Gn is the angle formed between the 2 planes: ArGo and GoGn	Baseline

Collaborators and Investigators

• Sponsor: University of Pavia
• Investigators: Principal Investigator: Andrea Scribante, DDS, Ms, PhD, University of Pavia

Study record dates

Study Major Dates

• Study Start (Actual): March 6, 2023
• Primary Completion (Actual): June 1, 2023
• Study Completion (Actual): June 7, 2023

Study Registration Dates

• First Submitted: February 17, 2023
• First Submitted That Met QC Criteria: March 4, 2023
• First Posted (Actual): March 16, 2023

Study Record Updates

• Last Update Posted (Actual): July 9, 2024
• Last Update Submitted That Met QC Criteria: July 6, 2024
• Last Verified: July 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Congenital Abnormalities
• Other Study ID Numbers: 2023-AGENESISTHIRDMOLAR

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: Data will be available upon motivated request to the Principal Investigator

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No