Development and Validation of a Risk Prediction Model for Preoperative Frailty in Elderly Patients With Colorectal Cancer

Fried Scale and its related scales were used to analyze the status and risk factors of preoperative frailty in elderly patients with colorectal cancer. R software was used to construct a risk prediction model for preoperative frailty in elderly patients with colorectal cancer, and its validity and stability were verified in clinical practice.

Study Overview

• Status: Recruiting
• Conditions: Colorectal Cancer

• Study Type: Observational
• Enrollment (Estimated): 364

Contacts and Locations

• Study Contact: Name: Yongmei Zhang; Phone Number: 13885257269; Email: hulizym@yeah.net

Study Locations

• China
  • Guizhou
    • Zunyi, Guizhou, China, 563000
      • Recruiting
      • Yongmei Zhang
      • Contact: Yongmei Zhang; Phone Number: 13885257269; Email: hulizym@yeah.net

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: N/A

• Sampling Method: Non-Probability Sample

Study Population

Patients who met the diagnostic criteria of colorectal cancer in Chinese Guidelines for Diagnosis and Treatment of Colorectal Cancer 2020 Edition and underwent surgery.

Description

Inclusion Criteria:

1. patients who met the diagnostic criteria of colorectal cancer in Chinese Guidelines for Diagnosis and Treatment of Colorectal Cancer 2020 Edition and underwent surgery;
2. patients aged ≥60 years old ;
3. patients who are clearly conscious, able to understand instructions, communicate normally, and complete the physical activity ability test without the assistance of others;
4. patients who gave informed consent and volunteered to participate in the study.

Exclusion Criteria:

1. patients with limb joint disease and lower limb pain;
2. patients with serious heart, liver, kidney diseases could not complete the test;
3. patients with visual impairment and hearing impairment;
4. patients with a history of mental illness or drug dependence;
5. taking antidepressants, levodopa/carbidopa, donepezil hydrochloride and other drugs ;
6. patients who received preoperative radiotherapy and chemotherapy;
7. Patients with hypothyroidism, Parkinson's disease, stroke and other diseases.

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Status of frailty	Status of frailty will be assessed by Fried Scale	1 day

Collaborators and Investigators

• Sponsor: Zunyi Medical College
• Investigators: Study Director: Yongmei Zhang, Zunyi Medical College

Study record dates

Study Major Dates

• Study Start (Actual): August 1, 2022
• Primary Completion (Estimated): July 31, 2025
• Study Completion (Estimated): July 31, 2025

Study Registration Dates

• First Submitted: May 19, 2023
• First Submitted That Met QC Criteria: May 19, 2023
• First Posted (Actual): May 30, 2023

Study Record Updates

• Last Update Posted (Actual): May 30, 2023
• Last Update Submitted That Met QC Criteria: May 19, 2023
• Last Verified: May 1, 2023

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Digestive System Diseases; Pathologic Processes; Neoplasms; Neoplasms by Site; Gastrointestinal Neoplasms; Digestive System Neoplasms; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Intestinal Neoplasms; Rectal Diseases; Colorectal Neoplasms; Frailty
• Other Study ID Numbers: ZSKHZ Zi (2022) no. 337

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No