- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05891457
Changes in Nerve Electro Physiologic Properties in Children Before and After Correction of Malnutrition
Changes in the Nerve Electro Physiologic Properties Before and After Correction of Malnutrition in Under-5 Children
The goal of this clinical trail study is to measure neurophysiologic parameters to assess the effect of malnutrition on the peripheral nervous system and their response to treatment in three categories (SAM, severe wasting, and severe stunting) of childhood malnutrition. 83 under-5 children from three categories of undernourished groups- severe stunting (n=30), Severe acute malnourished (n=22), wasting (n=31), and 45 age-matched healthy children from urban/peri-urban areas were enrolled.
SAm were provided with appropriate nutritional therapy/treatment that include supplementation of a high-calorie diet; i.e., F-100 milk and khichuri-halwa for nutritional rehabilitation. Egg milk and micronutrient supplementation were for recovery from severe stunting. Wasted children were treated with suitable local nutritional management (NM), such as infant and young child feeding practices (IYCF), providing MNP and nutrition education. Wasted children with medical complications were treated with specialized therapeutic milk (F-75) and those without medical complications were treated with a suitable local Nutritional Management (NM) & routine medicines to treat simple medical conditions at community nutrition center (CNC) with weekly follow up. At day 60 of intervention, children were again brought to icddr,b for a nerve conduction test.
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
The purpose of this study is to measure neurophysiologic parameters to assess the effect of malnutrition on peripheral nervous system and their response to treatment in three categories (SAM, severe wasting and severe stunting) of childhood malnutrition. The electrophysiological properties of peripheral nerves in malnourished under-5 children before and after correction of severe malnutrition were assed.
This is an exploratory study conducted in icddr,b, Dhaka, Bangladesh. 83 under-5 children from three categories of undernourished groups- severe stunting (length-for-age Z-scores <-3), SAM (weight-for-length Z-scores <-3, and/or mid-upper-arm circumference <11.5 cm, with or without nutritional edema) and wasting (weight-for-length Z-scores (WLZ) <-2) were enrolled. A total of 45 age-matched healthy children selected as controls. Participants were identified from urban/peri-urban areas of Dhaka city. After enrolment, participants were brought to icddr,b Dhaka Hospital and data on socio-economic status, weaning practice, morbidity, and dietary intake were collected. Nerve electro physiologic parameters assessed by motor (median, ulnar, fibular and tibial) and sensory (median, ulnar and sural) nerve conduction studies (NCS) on enrollment.
SAM were treated with appropriate nutritional therapy/treatment that included supplementation of high calorie diet; i.e., F-100 milk and khichuri-halwa for nutritional rehabilitation. Egg-milk and micronutrient supplementation were provided for 2 months for recovery from severe stunting (following standard guidelines for facility based management and recently conducted community based nutrition intervention studies). As per national guidelines, children suffering from severe wasting with medical complications were treated with specialized therapeutic milks (F-75) and those without medical complications treated with a suitable local Nutritional Management (NM) & routine medicines to treat simple medical conditions at community nutrition center (CNC) with weekly follow up. Children were monitored in the community for 2 months. Monthly anthropometry had been done. On day 60 or 2 months of intervention, children with weight-for-length/height Z-scores ≥-1 and MUAC >115 mm were again brought to icddr, b for nerve conduction test.
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
-
Dhaka, Bangladesh
- Icddr,b
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Child
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- Participants who will give informed written consent
- Children aged between 6 months to 5 years of age
- Children whose length/height-for-age <-3 (Stunted), weight-for-length/height <-2 (Wasted), and weight-for-length/height z scores <-3 and/or mid upper arm circumference <11.5 cm, with or without nutritional edema
- Children whose length/height-for-age, weight-for-length/height, and weight-for-length/height z score will be ≥1
Exclusion Criteria:
- Participants with congenital anomalies, twins and multiple pregnancies
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Health Services Research
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Malnourished children
|
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Compound muscle action potential (CMAP) amplitude
Time Frame: 60 days
|
Motor nerve compound muscle action potential (CMAP) amplitude is measured from baseline to peak amplitude for all the stimulation sites and expressed in millivolts (mV)
|
60 days
|
Motor nerve conduction velocity
Time Frame: 60 Days
|
Motor nerve conduction velocity is measured by the distance between the distal and proximal stimulation sites, divided by the difference in latency, and expressed in meters per second (m/s)
|
60 Days
|
Motor nerve corrected distal latency
Time Frame: 60 Days
|
Motor nerve corrected distal latency is measured from the onset (or rise of the negative deflection) of the compound muscle action potential and expressed in milliseconds (ms)
|
60 Days
|
Sensory nerve action potential (SNAP) amplitude
Time Frame: 60 Days
|
Sensory nerve action potential (SNAP) amplitude is measured from baseline-to-peak amplitude at the distal stimulation site and expressed in microvolts (μV)
|
60 Days
|
Sensory nerve conduction velocity
Time Frame: 60 Days
|
Sensory nerve conduction velocity is measured by the distance between the distal and proximal stimulation sites, divided by the difference in latency, and expressed in meters per second (m/s)
|
60 Days
|
Sensory nerve corrected distal latency
Time Frame: 60 Days
|
Sensory nerve corrected distal latency is measured from the onset (or rise of the negative deflection) of the compound muscle action potential and expressed in milliseconds (ms).
|
60 Days
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Changes in weight
Time Frame: 60 Days
|
Changes in weight measured in kg
|
60 Days
|
Changes in height
Time Frame: 60 Days
|
Changes in height measured in cm
|
60 Days
|
Changes in Mid Upper Arm Circumference (MUAC) for SAM
Time Frame: 60 Days
|
Changes in Mid Upper Arm Circumference (MUAC) measured in mm or cm
|
60 Days
|
Changes in weight-for-height Z score for SAM
Time Frame: 60 Days
|
Changes in weight-for-height Z score measured in points
|
60 Days
|
Changes in weight-for-height Z score for Wasted
Time Frame: 60 Days
|
Changes in weight-for-height Z score measured in points
|
60 Days
|
Changes in height-for-age Z score for Stunted
Time Frame: 60 Days
|
Changes in height-for-age Z score measured in points
|
60 Days
|
Collaborators and Investigators
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- PR-21013
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Wasting
-
National Taiwan University HospitalUnknownMalnutrition | Body Composition | Nutritional WastingTaiwan
-
National Taiwan University HospitalCompleted
-
National Taiwan University HospitalUnknownPeritoneal Dialysis | Wasting and MalnutritionTaiwan
-
The Hospital for Sick ChildrenMinistry of Health, Malawi; Nutriset; Schlumberger Foundation; Friends of Sick...RecruitingSevere Acute Malnutrition | Severe WastingMalawi
-
Assiut UniversityNot yet recruitingChronic Wasting Disease of Elk and Deer | Injury; Knee, Meniscus, Old Injury or Tear
-
Johns Hopkins UniversityWithdrawn
-
University Hospital, Basel, SwitzerlandRecruitingMuscle Wasting in Critically IllSwitzerland
-
NYU Langone HealthWithdrawnSIADH | Cerebral Hyponatremia | Cerebral Salt-wasting Syndrome | Reset Hypothalamic OsmostatUnited States
-
Hospital Civil Juan I. MenchacaNot yet recruitingMalnutrition | Peritoneal Dialysis | Oxidative Stress | Protein-Energy Malnutrition | Protein-Energy Wasting | Oral Nutritional Supplements
-
National Taiwan University HospitalRecruitingChild Development | Cachexia; Cancer | Adolescent Development | Muscle WastingTaiwan
Clinical Trials on Nutritional Intervention
-
Clinica Universidad de Navarra, Universidad de...Recruiting
-
China-Japan Friendship HospitalRecruiting
-
HAN University of Applied SciencesFrieslandCampina; HAS Hogeschool; Centre of Expertise Food (CoE Food); SligroCompletedMalnutrition; Protein | Protein MalnutritionNetherlands
-
OHSU Knight Cancer InstituteNational Cancer Institute (NCI)CompletedObesity | OverweightUnited States
-
Gødstrup HospitalDanish Cancer SocietyNot yet recruitingCancer | Malnutrition | Nutritional InterventionDenmark
-
CHU de Quebec-Universite LavalCanadian Institutes of Health Research (CIHR); Laval UniversityRecruitingPregnancy Complications | Gestational DiabetesCanada
-
Johannes Gutenberg University MainzGoethe UniversityCompletedDiabetes Mellitus, Type 2 | Hyperlipidemias | NASH - Nonalcoholic SteatohepatitisGermany
-
Hospices Civils de LyonCompleted
-
University of ZurichCompletedHealthy ControlsSwitzerland