- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05921851
Exploration of Early Warning System of Cardiac Arrest and Early Intervention
June 26, 2023 updated by: Peking Union Medical College Hospital
The high incidence rate, high Case fatality rate rate and high rate of neurological impairment of cardiac arrest pose a serious threat to the health of the whole population, and also bring a huge economic burden.
In recent years, the "American Heart Association AHA Cardiopulmonary resuscitation and Cardiovascular Emergency Guide" has always emphasized the importance of "life chain" for the survival of patients with cardiac arrest.
The hospital's survival chain emphasizes early warning recognition and activation of emergency response systems, immediate high-quality CPR, rapid defibrillation, advanced life support, and post arrest care.
However, there is an urgent need for improvement and enhancement in all aspects of the chain of life for cardiac arrest.
Millimeter wave radar can transmit radar signals that penetrate non-metallic substances such as clothing, detect the micro motion signals caused by human respiration and heartbeat, and then process the signals.
By calculating the frequency or phase shift information in the radar echo, patient activity information can be obtained, achieving contactless and real-time detection of patient activity in the room.
And it can achieve tracking of targets in scenarios where multiple people exist, while monitoring the physical signs of each target in real-time [7]; Our team has developed Cardiopulmonary resuscitation Quality Monitoring Index (CQI) and Cardiopulmonary resuscitation Ventilation Mode (CPRV) in the early stage, which are very helpful to monitor and improve the quality of Cardiopulmonary resuscitation; In recent years, the application of bedside echocardiography (PoCUS) in emergency has been significantly expanded.
Although transthoracic echocardiography (TTE) can provide valuable diagnostic information for patients with cardiac arrest, it has important limitations in dynamic compression of Cardiopulmonary resuscitation.
TEE can overcome many limitations of TTE, and the combination of the two can achieve visualization of resuscitation, Many signs of Cardiopulmonary resuscitation that had not been found before have been found.
On the other hand, international guidelines recommend that the compression site of Cardiopulmonary resuscitation should be in the lower half of the sternum.
However, research shows that there are great changes in the shape of the chest and the organizational structure directly below the compression site in normal people.
The left ventricle is located in the lower quarter of the sternum, lower than the lower third of the sternum.
When Cardiopulmonary resuscitation is carried out according to the current guidelines, only a small part of the ventricle is subjected to external compression, and for spinal deformity, obesity There is no corresponding research and recommendation for pregnant women and other special groups, and the extensive development of chest CT Iterative reconstruction provides the possibility of individualized evaluation.
In addition, the COVID-19 in China has not yet been completely controlled.
For patients suspected or confirmed to be infected with novel coronavirus, it is still challenging to carry out Cardiopulmonary resuscitation that may produce aerosols when wearing protective equipment.
In summary, establishing a clinical decision-making system for the survival chain under the new situation and optimizing the survival chain process in the guidelines is of great significance for improving the survival rate and prognosis of patients with cardiac arrest, and is of great value for improving national health levels and reducing the economic burden on the government.
Study Overview
Study Type
Observational
Enrollment (Estimated)
12500
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: huadong Zhu
- Phone Number: 13910696435
- Email: zhuhuadong1970@126.com
Study Locations
-
-
Beijing
-
Beijing, Beijing, China
- Recruiting
- Peking Union Medical College Hospital
-
Contact:
- yecheng Liu
- Phone Number: 18910851501
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
No
Sampling Method
Non-Probability Sample
Study Population
Enter the emergency room/ICU ward of Peking Union Medical College Hospital during 2019.1-2022.1 and 2022.12-2023.12 (emergency room)Diagnosing non flowing patients
- Age ≥ 18 years old, regardless of gender.
- No sudden cardiac arrest occurred upon admission.
- Laboratory tests are available within 24 hours before cardiac arrest occurs.
- Be able to understand the research protocol and willing to participate in this study, and provide written informed consent (applicable to Prospective cohort study).
Description
Inclusion Criteria:
- Enter the emergency room/ICU ward of Peking Union Medical College Hospital during 2019.1-2022.1 and 2022.12-2023.12 (emergency room)Diagnosing non flowing patients
- Age ≥ 18 years old, regardless of gender.
- No sudden cardiac arrest occurred upon admission.
- Laboratory tests are available within 24 hours before cardiac arrest occurs.
- Be able to understand the research protocol and willing to participate in this study, and provide written informed consent (applicable to Prospective cohort study).
Exclusion Criteria:
- Stay time is less than 24 hours.
- Trauma patients.
- Patients with sudden cardiac arrest outside the hospital.
- Refuse to participate and sign the informed consent form (applicable to the Prospective cohort study part
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
cardiac arrest
Cardiac arrest group: Patients who experience cardiac arrest during emergency diagnosis and treatment will use the time of cardiac arrest as the event time.
|
no intervention
|
control
The patient did not experience sudden cardiac arrest during the emergency diagnosis and treatment period, and was treated at the 24-hour time window in the emergency roomCollect data and use the end of the window as the event time.
|
no intervention
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Occurrence of cardiac arrest
Time Frame: 24 hours
|
24 hours
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
October 1, 2022
Primary Completion (Estimated)
September 30, 2025
Study Completion (Estimated)
September 30, 2025
Study Registration Dates
First Submitted
June 18, 2023
First Submitted That Met QC Criteria
June 26, 2023
First Posted (Actual)
June 27, 2023
Study Record Updates
Last Update Posted (Actual)
June 27, 2023
Last Update Submitted That Met QC Criteria
June 26, 2023
Last Verified
June 1, 2023
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- K2993-K23C0266
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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