A Prospective Longitudinal Study in Adults With Multifocal Motor Neuropathy (iMMersioN)

May 27, 2026 updated by: argenx

A Multicenter Prospective Longitudinal Study of Clinical Outcomes, Disease Course, Health-Related Quality of Life, and Health Care Resource Utilization in Adult Patients With Multifocal Motor Neuropathy

This prospective longitudinal study will follow participants with Multifocal Motor Neuropathy over time and collect data on their clinical outcomes, quality of life, and use of health care resources. Participants will follow their regular visit schedule with their treating physician, except for an optional second visit occurring 7 to 14 days after the start of the study to collect biomarker data. No IMP will be administered.

Study Overview

Status

Active, not recruiting

Conditions

Study Type

Observational

Enrollment (Actual)

413

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Australia
      • Parkville, Australia, 3050
        • Royal Melbourne Hospital
      • Southport, Australia, 4215
        • Gold Coast University Hospital
      • Woolloongabba, Australia, 4102
        • Princess Alexandra Hospital
  • Austria
      • Vienna, Austria, 1090
        • Allgemeines Krankenhaus der Stadt Wien (AKH Wien)
  • Belgium
      • Brussels, Belgium, 1070
        • Hôpital Erasme
      • Edegem, Belgium, 2650
        • Universitair Ziekenhuis Antwerpen
      • Ghent, Belgium, 9000
        • Universitair Ziekenhuis Gent
      • Jette, Belgium, 1090
        • Universitair Ziekenhuis Brussel
      • Leuven, Belgium, 3000
        • Universitair Ziekenhuis Leuven - Campus Gasthuisberg
      • Liège, Belgium, 4000
        • L'hopital de la Citadelle - Site Citadelle
      • Woluwe-Saint-Lambert, Belgium, 1200
        • Cliniques Universitaires Saint-Luc
  • Bulgaria
      • Panagyurishte, Bulgaria, 4500
        • Multiprofile Hospital for Active Treatment - Uni Hospital OOD
      • Pleven, Bulgaria, 5800
        • Medical Center Medconsult Pleven OOD
      • Pleven, Bulgaria, 5800
        • Military Medical Academy - Military Hospital for Active Treatment Pleven
      • Sofia, Bulgaria, 1606
        • University Multiprofile Hospital for Active Treatment and Emergency Medicine N. I. Pirogov
  • Canada
      • London, Canada, N6A 5A5
        • London Health Sciences Centre - University Hospital
      • Montreal, Canada, H2X 0C1
        • Centre Hospitalier de l'Université de Montréal
      • Montreal, Canada, H3A 2B4
        • McGill University Health Centre - The Neuro (Montreal Neurological Institute-Hospital)
      • Québec, Canada, G1J 1Z4
        • CHU de Quebec - Hopital de L'enfant Jesus
      • Saskatoon, Canada, S7H 0G9
        • University of Saskatchewan - University of Saskatchewan College of Medicine
  • China
      • Changsha, China, 410008
        • Xiangya Hospital of Central South University
      • Nanchang, China, 330006
        • The First Affiliated Hospital of Nanchang University
      • Shanghai, China
        • Huashan Hospital of Fudan University
  • Czechia
      • Brno, Czechia, 62500
        • Fakultni nemocnice Brno - Areal Bohunice
      • Hradec Králové, Czechia, 500 05
        • Fakultni nemocnice Hradec Kralove
  • Denmark
      • Aarhus, Denmark, 8200
        • Aarhus Universitetshospital
      • Copenhagen, Denmark, 2100
        • Rigshospitalet - Blegdamsvej
  • France
      • Angers, France, 49933
        • CHU Angers
      • Bordeaux, France, 33000
        • CHU de Bordeaux - Hôpital Pellegrin
      • Brest, France, 29200
        • CHU Brest - Hôpital La Cavale Blanche
      • Bron, France, 69500
        • Hospices Civils de Lyon (HCL) - Hopital Pierre Wertheimer
      • Le Kremlin-Bicêtre, France, 94270
        • Assistance Publique Hopitaux de Paris (AP-HP) - Hopital Bicetre
      • Lille, France, 59037
        • CHU Lille - Hopital Salengro
      • Limoges, France, 87042
        • CHU de Limoges - CHU Dupuytren 1
      • Marseille, France, 13385
        • AP-HM - CHU Timone
      • Nantes, France, 44093
        • CHU de Nantes - Hôtel Dieu
      • Nice, France, 06001
        • CHU de Nice - Hopital Pasteur
      • Paris, France, 75013
        • Assistance Publique Hopitaux de Paris (AP-HP) - Hopital Pitie-Salpetriere
  • Germany
      • Essen, Germany, 45147
        • Universitätsklinikum Essen
      • Giessen, Germany, 35385
        • Universitatsklinikum Giessen und Marburg - Campus Giessen
      • Hanover, Germany, 30625
        • Medizinische Hochschule Hannover
      • Potsdam, Germany, 14471
        • St. Josefs- Krankenhaus Potsdam- Sanssouci
      • Würzburg, Germany, 97080
        • Universitätsklinikum Würzburg
  • Italy
      • Florence, Italy, 50134
        • Azienda Ospedaliero Universitaria Careggi
      • Gussago, Italy, 25064
        • Fondazione Serena Onlus - NeMO Brescia
      • Messina, Italy, 98125
        • Azienda Ospedaliera Universitaria Gaetano Martino
      • Novara, Italy, 28100
        • Universita degli Studi del Piemonte Orientale Amedeo Avogadro - Scuola di Medicina
      • Orbassano, Italy, 10043
        • Azienda Ospedaliero-Universitaria San Luigi Gonzaga
      • Palermo, Italy, 90129
        • Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone
      • Pavia, Italy, 27100
        • Istituto Neurologico Nazionale a Carattere Scientifico IRCCS
      • Pisa, Italy, 56126
        • Azienda Ospedaliero Universitaria Pisana - Ospedale Santa Chiara
      • Roma, Italy, 133
        • Fondazione Ptv Policlinico Tor Vergata
      • Roma, Italy, 00189
        • Azienda Ospedaliero Universitaria Sant'Andrea
  • Japan
      • Itabashi-ku, Japan, 173-8606
        • Teikyo University Hospital
      • Kodaira-shi, Japan, 187-8551
        • National Center of Neurology and Psychiatry
      • Mibu, Japan, 321-0293
        • Dokkyo Medical University Hospital
  • Latvia
      • Riga, Latvia, LV-1002
        • Pauls Stradins Clinical University Hospital
      • Riga, Latvia, 1038
        • Riga East Clinical University Hospital
  • Poland
      • Bydgoszcz, Poland, 85-065
        • Medicover Integrated Clinical Services (MICS) - Centrum Medyczne Bydgoszcz
      • Katowice, Poland, 40-123
        • Wielospecjalistyczna Poradnia Lekarska Synapsis
      • Krakow, Poland, 31-426
        • Michalski i Partnerzy Lekarze Spolka Partnerska
      • Krakow, Poland, 30-539
        • Specjalistyczne Gabinety Sp. z o.o.
      • Krakow, Poland, 31-503
        • SP ZOZ Szpital Uniwersytecki w Krakowie
      • Lublin, Poland, 20-093
        • CLINIREM Sp z o.o.
      • Lublin, Poland, 20-605
        • Rejdak Konrad Indywidualna Praktyka Lekarska
      • Lublin, Poland, 20-701
        • Centrum Medyczne Hope Clinic
      • Warsaw, Poland, 02-677
        • ETG Network - ETG Neuroscience
  • Romania
      • Constanța, Romania, 900591
        • Spitalul Clinic Judetean de Urgenta Sf. Apostol Andrei
  • Serbia
      • Belgrade, Serbia, 11000
        • Univerzitetski Klinicki Centar Srbije
      • Kragujevac, Serbia, 34000
        • Univerzitetski klinicki centar Kragujevac
  • Spain
      • Alicante, Spain, 03010
        • Hospital General Universitario Dr. Balmis
      • Badalona, Spain, 08916
        • Hospital Universitari Germans Trias i Pujol (HUGTP)
      • Barcelona, Spain, 08041
        • Hospital De La Santa Creu I Sant Pau
      • Bilbao, Spain, 48013
        • Hospital Universitario de Basurto
      • L'Hospitalet de Llobregat, Spain, 08907
        • Hospital Universitari de Bellvitge
      • Oviedo, Spain, 33011
        • Hospital Universitario Central de Asturias
      • Pamplona, Spain, 31008
        • Hospital Universitario de Navarra
      • San Sebastián, Spain, 20014
        • Hospital Universitario de Donostia
  • Sweden
      • Gothenburg, Sweden, 413 45
        • Sahlgrenska Universitetssjukhuset - MS - mottagning Sahlgrenska
      • Huddinge, Sweden, 141 57
        • Karolinska universitetssjukhuset - Huddinge
  • United Kingdom
      • Bristol, United Kingdom, BS10 5NB
        • North Bristol NHS Trust - Southmead Hospital Bristol
      • Fulwood, United Kingdom, PR2 9HT
        • Lancashire Teaching Hospitals NHS Foundation Trust - Royal Preston Hospital
      • Glasgow, United Kingdom, G51 4TF
        • NHS Great Glasgow and Clyde - Queen Elizabeth University Hospital
      • Nottingham, United Kingdom, NG7 2UH
        • Nottingham University Hospitals NHS Trust - Queen's Medical Centre
      • Oxford, United Kingdom, OX3 9DU
        • Oxford University Hospitals NHS Foundation Trust - John Radcliffe Hospital
      • Salford, United Kingdom, M6 8HD
        • Northern Care Allicance NHS Foundation Trust - Salford Royal
      • Sheffield, United Kingdom, S10 2JF
        • Sheffield Teaching Hospitals NHS Foundation Trust - Royal Hallamshire Hospital
      • Taunton, United Kingdom, TA1 5DA
        • Somerset NHS Foundation Trust - Musgrove Park Hospital
      • Truro, United Kingdom, TR1 3LJ
        • Royal Cornwall Hospitals NHS Trust - Royal Cornwall Hospital
  • United States
    • Arizona
      • Phoenix, Arizona, United States, 85028
        • Neuromuscular Clinical and Research Center
      • Scottsdale, Arizona, United States, 85251
        • HonorHealth Neurology - Bob Bove Neuroscience Institute
    • California
      • Orange, California, United States, 92868
        • UCI Health - ALS and Neuromuscular Center
      • Palo Alto, California, United States, 94304
        • Stanford Medicine Health Care - Stanford Neuroscience Health Center
      • Pomona, California, United States, 91767-2009
        • The Neurology Group
      • Rancho Mirage, California, United States, 92270
        • Eisenhower Health - Rancho Mirage Medical Center
      • Sacramento, California, United States, 95817-2307
        • UC Davis Health - Lawrence J. Ellison Ambulatory Care Center
      • San Francisco, California, United States, 94143-2204
        • UCSF Health - UCSF Medical Center
    • Colorado
      • Aurora, Colorado, United States, 80045
        • University of Colorado - Anschutz Medical Campus
    • Connecticut
      • New Haven, Connecticut, United States, 06520
        • YaleNewHavenHealth - Yale New Haven Hospital
    • District of Columbia
      • Washington D.C., District of Columbia, United States, 20007
        • MedStar Georgetown University Hospital
    • Florida
      • Port Charlotte, Florida, United States, 33952
        • Medsol Clinical Research Center Inc
      • Tamarac, Florida, United States, 33321
        • D&H National Research Centers - Tamarac Research Center
    • Illinois
      • O'Fallon, Illinois, United States, 62269
        • Hospital Sisters Health System (HSHS) - St Elizabeth's Hospital
    • Kansas
      • Kansas City, Kansas, United States, 66103
        • The University of Kansas Health System - Landon Center on Aging
    • Maryland
      • Chevy Chase, Maryland, United States, 20815-6902
        • MedStar Georgetown University Hospital
    • New Jersey
      • New Brunswick, New Jersey, United States, 08901
        • Rutgers University - Robert Wood Johnson Medical School
    • New York
      • New York, New York, United States, 10032
        • Columbia University Irving Medical Center - Neurological Institute of New York
    • North Carolina
      • Chapel Hill, North Carolina, United States, 27599-7025
        • University of North Carolina - Chapel Hill
    • Ohio
      • Columbus, Ohio, United States, 43221-3502
        • Ohio State University Wexner Medical Center - Ohio State Martha Morehouse Outpatient Care
    • Oregon
      • Portland, Oregon, United States, 97239
        • Oregon Health and Science University (OHSU) Hospital - Marquam Hill Campus
    • Pennsylvania
      • Philadelphia, Pennsylvania, United States, 19104
        • Penn Medicine - Perelman Center for Advanced Medicine
      • Philadelphia, Pennsylvania, United States, 19104
        • Penn Medicine - Penn Medicine University City
      • Pittsburgh, Pennsylvania, United States, 15213
        • University of Pittsburgh Medical Center
    • Texas
      • Cypress, Texas, United States, 77429
        • Northwest Houston Neurology - Cypress

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Probability Sample

Study Population

Patients with MMN receiving standard of care at their treating physician.

Description

Inclusion Criteria:

  • Is at least the local legal age of consent for clinical studies when signing the ICF
  • Is capable of providing signed informed consent and complying with protocol requirements
  • Has an existing or new diagnosis of MMN made by a neuromuscular specialist or neurologist

Exclusion Criteria:

  • Is currently participating in any clinical study with an IMP
  • Has other medical conditions that could affect the assessment of MMN

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
To characterize MMN patient profiles for participants
Time Frame: up to 61 months
up to 61 months
To assess the MMN disease management and disease course
Time Frame: up to 61 months
up to 61 months
To assess outcome measures specific to MMN disease and their evolution over time
Time Frame: up to 61 months
up to 61 months
To estimate the burden of MMN on participants' quality of life
Time Frame: up to 61 months
up to 61 months
To estimate the economic burden for participants with MMN
Time Frame: up to 61 months
up to 61 months
To collect data on relevant disease biomarkers
Time Frame: up to 61 months
up to 61 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

argenx

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

November 29, 2023

Primary Completion (Estimated)

December 31, 2028

Study Completion (Estimated)

December 31, 2028

Study Registration Dates

First Submitted

August 4, 2023

First Submitted That Met QC Criteria

August 4, 2023

First Posted (Actual)

August 14, 2023

Study Record Updates

Last Update Posted (Actual)

May 29, 2026

Last Update Submitted That Met QC Criteria

May 27, 2026

Last Verified

March 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • ARGX-117-2202

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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