Strength Training and Muscle Lipids (Strength-Lip)

The Effects of Strength Training on Neuromuscular Function and Muscle Lipids.

The purpose of this study is examine the effects of 8 weeks (3 days/week) of resistance exercise training in children 8 to 10 years of age on muscle strength and power, motor unit activation, and lipid profiles of the vastus lateralis.

Study Overview

• Status: Completed
• Conditions: Healthy
• Intervention / Treatment: Other: Resistance exercise training

• Study Type: Interventional
• Enrollment (Actual): 14
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • Kansas
    • Kansas City, Kansas, United States, 66103
      • Hoglund Biomedical Imaging Center
    • Lawrence, Kansas, United States, 66045
      • Neuromechanics Laboratory
    • Overland Park, Kansas, United States, 66213
      • Exercise and Human Performance Laboratory
    • Overland Park, Kansas, United States, 66213
      • Metabolic and Body Composition Laboratory

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Healthy volunteer males and females ages 8 - 10 years.

Exclusion Criteria:

• No history or ongoing neuromuscular diseases.
• No history or ongoing musculoskeletal injuries.
• No history or ongoing disease that effects metabolism.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Non-Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
No Intervention: Control
Experimental: Resistance exercise training	Other: Resistance exercise training; Participants will strength train via linear periodization resistance exercise training.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in muscular power of the leg extensors, as measured with isokinetic strength testing.	The score will reflect the muscular power of the leg extensors. The higher score, reflects greater muscular strength.	Baseline, following the intervention (9 weeks)

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change from baseline in thigh muscle cross-sectional area	Scores are measured cross-sectional area from ultrasound images. The higher score, reflects greater muscle size of the leg extensors.	Baseline, following the intervention (9 weeks)

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change from baseline in the fatty acid saturation levels of the extramyocellular lipids of the vastus lateralis, as measure with magnetic resonance spectroscopy	The score will reflect a saturation level of fatty acids in the extramyocellular lipid. The higher score, reflects greater fatty acid saturation.	baseline, following the intervention (9 weeks)
Change from baseline in the fatty acid saturation levels of the intramyocellular lipids of the vastus lateralis, as measure with magnetic resonance spectroscopy	The score will reflect a saturation level of fatty acids in the intramyocellular lipid. The higher score, reflects greater fatty acid saturation.	baseline, following the intervention (9 weeks)
Change from baseline in intramyocellular lipids of the vastus lateralis, as measure with magnetic resonance spectroscopy	The score will reflect a concentration. The higher score, reflects more fat in the fibers.	baseline, following the intervention (9 weeks)
Change from baseline in extramyocellular lipids of the vastus lateralis, as measure with magnetic resonance spectroscopy	The score will reflect a concentration. The higher score, reflects more fat in the fibers.	baseline, following the intervention (9 weeks)
Change from baseline in motor unit activation, as measured with surface electromyography decomposition.	The score will reflect the firing rates of recorded motor units. The higher score, reflects greater motor unit activation.	baseline, following the intervention (9 weeks)
Change in total body lean mass, as measured with bioelectrical impedance analysis.	The score will reflect the lean mass. The higher score, reflects greater lean mass.	baseline, following the intervention (9 weeks)
Change in total body fat mass, as measured with bioelectrical impedance analysis.	The score will reflect the fat mass. The higher score, reflects greater fat mass.	baseline, following the intervention (9 weeks)

Collaborators and Investigators

• Sponsor: University of Kansas Medical Center
• Collaborators: National Strength and Conditioning Association

Study record dates

Study Major Dates

• Study Start (Actual): July 1, 2024
• Primary Completion (Actual): December 7, 2024
• Study Completion (Actual): December 7, 2024

Study Registration Dates

• First Submitted: June 24, 2024
• First Submitted That Met QC Criteria: June 24, 2024
• First Posted (Actual): June 28, 2024

Study Record Updates

• Last Update Posted (Actual): August 20, 2025
• Last Update Submitted That Met QC Criteria: August 14, 2025
• Last Verified: August 1, 2025

More Information

Terms related to this study

• Keywords: exercise; muscle power; intramyocellular lipids; muscle cross-sectional area; extramyocellular lipids; motor unit
• Other Study ID Numbers: STUDY00160469

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No