Predictive Role of Glucose/Potassium Ratio on Mortality in Major Burns.

The Predictive Role of Glucose/Potassium Ratio for Mortality in Patients With Major Burn Trauma

The aim of this observational study is to investigate the role of the glucose-potassium ratio in predicting mortality in patients with major burn trauma.

The main question it aims to answer is: Can the glucose-potassium ratio predict mortality in major burn patients? The glucose-to-potassium ratios of major burn patients at the time of initial hospitalization will be determined, and their relationship with mortality will be analyzed.

Study Overview

• Status: Completed
• Conditions: Burns; Burn Injury; Inhalation Injury

Detailed Description

Major burns, especially electrical burns, facial burns, inhalation burns, burns with large burn surface areas, and deep burns, have a high mortality risk. Early detection of this risk may be critical to reducing mortality rates. For this reason, trauma centers are working on rapid and effective prognostic markers. In trauma and stress situations, glucose levels rise while potassium levels fall due to increased catecholamines. The literature reports that hyperglycemia, also known as the glucose-potassium ratio, can rapidly and effectively predict morbidity and mortality in patients suffering from subarachnoid hemorrhage, pulmonary embolism, traumatic brain injury, or blunt abdominal trauma. Many publications show that increased glucose is associated with mortality and morbidity in critical illnesses and trauma. The isolated glucose-potassium ratio has a higher predictive ability for mortality and morbidity compared to glucose and potassium levels. In this study, investigators aimed to examine the prognostic value of the glucose-to-potassium ratio in participants with major burn trauma.

• Study Type: Observational
• Enrollment (Actual): 200

Contacts and Locations

Study Locations

• Turkey
  • Konya, Turkey, 42090
    • Konya Training and Research Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

The study population consisted of patients of all age groups who were admitted to the burn center between May 2022 and May 2024 with 2nd degree and deeper burns of 40% and above total burn surface area, 3rd and 4th degree burns of 20% and above total burn surface area, and inhalation burns. Patients with missing data, patients with burn trauma of more than 24 hours since the onset of burn trauma, 1st degree burns, patients with diabetes mellitus or renal failure, and patients using potassium-regulating drugs were excluded from the study.

Description

Inclusion Criteria:

• All burns >40% of total body surface area (2nd degree or deeper)
• Burns with inhalation injury
• Burns >20% of total body surface area 3nd degree or deeper

Exclusion Criteria:

• First degree burns
• Patients have more than 24 hours since the onset of burn trauma
• Patients with diabetes mellitus
• Patients with chronic renal failure
• Patients taking potassium-modifying medication
• Patients with missing data

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Glucose-to-potassium ratio	The glucose-to-potassium ratio is calculated by dividing the participants' glucose values when they first apply to the hospital by their potassium values.	2 days

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Female/Male ratio	It is calculated by dividing the number of females by the number of males in the study population.	2 days
Mean percent of total body surface area burned	It is calculated by adding the total burn surface area percentage values of all patients and dividing by the number of participants.	2 days
Burn infection rate	The number of patients developing burn infection is calculated by dividing by the number of all participants.	2 days
Mortality rate	The mortality rate is calculated by dividing the number of patients who developed mortality by the number of all participants.	2 days

Collaborators and Investigators

• Sponsor: Konya Meram State Hospital
• Investigators: Principal Investigator: Alpaslan Sahin, Assoc. Prof., Principal Investigator

Study record dates

Study Major Dates

• Study Start (Actual): May 1, 2022
• Primary Completion (Actual): May 1, 2024
• Study Completion (Actual): July 1, 2024

Study Registration Dates

• First Submitted: August 17, 2024
• First Submitted That Met QC Criteria: August 17, 2024
• First Posted (Actual): August 20, 2024

Study Record Updates

• Last Update Posted (Actual): August 21, 2024
• Last Update Submitted That Met QC Criteria: August 19, 2024
• Last Verified: August 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Burns; Wounds and Injuries
• Other Study ID Numbers: Konya Burn Center

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No