Multicenter Retrospective Study on Streptobacillus Moniliformis Infections in France (Streptobacil)

November 28, 2024 updated by: University Hospital, Strasbourg, France

French data on Streptobacillus moniliformis infections (zoonosis transmitted by rat bites) are rare and there are no case series in the literature to date. This is a pathology presenting atypical clinical manifestations for a bacterial infection and which therefore remains underdiagnosed. Streptobacillus moniliformis infections can be fatal without appropriate antibiotic treatment. This study could improve diagnosis, develop early treatment strategies and contribute to the overall understanding of zoonotic diseases

Study Overview

Status

Recruiting

Conditions

Streptobacillus Moniliformis Infections

Study Type

Observational

Enrollment (Estimated)

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Name: François DANION, MD
Phone Number: 33 3 69 55 15 88
Email: francois.danion@chru-strasbourg.fr

Study Locations

France
- - Strasbourg, France, 67091
    - Recruiting
    - Service des Maladies Infectieuses et Tropicales - CHU de Strasbourg - France
    - Contact:
      
      François DANION, MD
      
      Phone Number: 33 3 69 55 15 88
      
      Email: francois.danion@chru-strasbourg.fr
    - Principal Investigator:
      
      François DANION, MD
    - Sub-Investigator:
      
      Frédéric SCHRAMM, MD
    - Principal Investigator:
      
      Amandine ROBERT, MD
    - Principal Investigator:
      
      GUILLOUZOUIC GUILLOUZOUIC, PharmD

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

Child
Adult
Older Adult

Accepts Healthy Volunteers

Sampling Method

Non-Probability Sample

Study Population

Patient having Streptobacillus moniliformis infection between 01/01/2007 and 31/12/2023

Description

Inclusion Criteria:

Minor patient aged 1 to 17 years
Adult patient ≥18 years
Proven Streptobacillus moniliformis infection between 01/01/2007 and 31/12/2023
Subject not objecting, after being informed, to the reuse of their data for the purposes of this research
Holders of parental authority not objecting, after being informed, to the reuse of their data for the purposes of this research their child for the purposes of this research

Exclusion Criteria:

Subject and/or holder of parental authority having expressed opposition to participating in the study

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Retrospective study of the effectiveness of antibiotic therapy initiated for the treatment of Streptobacillus moniliformis infection. Time Frame: Negative blood culture 15 days after the start of antibiotic therapy.	Clinical cure 15 days after the start of antibiotic therapy. This cure is based on a negative blood culture (absence of germs) performed 15 days after the start of treatment.	Negative blood culture 15 days after the start of antibiotic therapy.

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University Hospital, Strasbourg, France

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

February 16, 2024

Primary Completion (Estimated)

February 16, 2025

Study Completion (Estimated)

February 16, 2025

Study Registration Dates

First Submitted

August 21, 2024

First Submitted That Met QC Criteria

November 28, 2024

First Posted (Estimated)

December 2, 2024

Study Record Updates

Last Update Posted (Estimated)