Vitamin D, Hashimato's Thyroiditis and Thyroid Functions

December 5, 2024 updated by: Rahime Evra KARAKAYA, Ankara Yildirim Beyazıt University

The Relationship Between Vitamin D Levels, Thyroid Functions, and Thyroid Autoimmunity

The goal of this retrospective observational study is to determine whether vitamin D levels differ in patients with Hashimoto's thyroiditis (HT) compared to those without Hashimoto's thyroiditis. The main research questions are:

Are vitamin D levels lower in HT patients compared to non-HT patients? Do vitamin D levels vary between HT and non-HT patients based on thyroid function status?

The study was conducted by retrospectively reviewing the medical records of patients who visited the hospital outpatient clinic.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Actual)

81180

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Turkey
    • Çankaya
      • Ankara, Çankaya, Turkey, 06800
        • Ankara Bilkent City Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Sampling Method

Non-Probability Sample

Study Population

Patients who apply to the Endocrinology Clinic of Ankara Bilkent City Hospital

Description

Inclusion Criteria:

Patients with the following biochemical parameters:

  • Vitamin D (25(OH)D) levels
  • Thyroid-stimulating hormone (TSH) levels
  • Free triiodothyronine (fT3) levels
  • Free thyroxine (fT4) levels
  • Anti-thyroid peroxidase (anti-TPO) levels
  • Anti-thyroglobulin (anti-Tg) levels

Exclusion Criteria:

-

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Adults
Patients with thyroid function tests (thyroid-stimulating hormone (TSH), free T3 (fT3), free T4 (fT4)), thyroid antibodies (anti-Tg, anti-TPO), and 25(OH) vitamin D levels
Diagnostic test: vitamin D 25(OH)D
Thyroid functions (thyroid-stimulating hormone (TSH), serbest triiodothyronine (fT3), serbest thyroxine (fT4)); Thyroid antibodies (Anti-thyroid peroxidase (anti-TPO), anti-thyroglobulin (anti-TG))
Other Names:
  • Thyroid functions
  • Thyroid antibodies

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Vitamin D 25 OH D
Time Frame: Baseline
nmol/L
Baseline
thyroid-stimulating hormone (TSH)
Time Frame: Baseline
uIU/mL
Baseline
free thyroxine (fT4)
Time Frame: Baseline
ng/dL
Baseline
Anti-thyroid peroxidase (anti-TPO)
Time Frame: Baseline
IU/mL
Baseline
anti-thyroglobulin (anti-TG)
Time Frame: Baseline
IU/mL
Baseline

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
free triiodothyronine (fT3)
Time Frame: Baseline
pg/ml
Baseline

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Ankara Yildirim Beyazıt University

Collaborators

Ankara Bilkent City Hospital

Investigators

  • Principal Investigator: Rahime E Karakaya, PhD, Ankara Yildirim Beyazıt University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

February 1, 2019

Primary Completion (Actual)

January 1, 2024

Study Completion (Actual)

January 1, 2024

Study Registration Dates

First Submitted

December 5, 2024

First Submitted That Met QC Criteria

December 5, 2024

First Posted (Estimated)

December 10, 2024

Study Record Updates

Last Update Posted (Estimated)

December 10, 2024

Last Update Submitted That Met QC Criteria

December 5, 2024

Last Verified

December 1, 2024

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • AnkaraYBU-KARAKAYA005

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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