Effect of Sleep Extension in Prevention to Sleep Deprivation (SLEEPERF)

Effect of Sleep Extension in Prevention to Sleep Deprivation on Running Endurance Performance

The approach of a competition can be associated to a decrease in sleep duration and quality which can negatively impact athlete's performance and health (injury risk, fall, accident). Ultra-endurance competitions even involve partial and/or total sleep deprivation over one or several nights. Studied investigating this question suggest that endurance performance under sleep deprivation is altered, mainly because of an effect on the rate of perceived exertion (RPE), which regulates effort intensity. One of the methods used by athletes to limit the impact of sleep deprivation in competition is to implement sleep extension in the days prior to a competition. However, few studies have investigated the impact of sleep deprivation et its reproducibility on performance and fatigue during a prolonged running exercise, as well as the efficiency of prior sleep extension. The importance of such a preventive measure might also depend on individual resistance to sleep deprivation, which is variable between persons and could have genetic determinants. This aspect remains under-studied, particularly regarding the impact of sleep deprivation on physical performance. Therefore, this study aims at investigating the effects of sleep deprivation and prior sleep extension on prolonged duration performance.

Study Overview

• Status: Recruiting
• Conditions: Healthy
• Intervention / Treatment: Other: Reproductibility; Other: Total sleep deprivation; Other: partial sleep deprivation

• Study Type: Interventional
• Enrollment (Estimated): 69
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Léonard FEASSON, PhD; Phone Number: 33 04 77 12 03 83; Email: leonard.feasson@univ-st-etienne.fr
• Study Contact Backup: Name: Diana RIMAUD, science Doctor; Phone Number: 33 0477120467; Email: diana.rimaud@chu-st-etienne.fr

Study Locations

• France
  • Saint-etienne, France, 42055
    • Recruiting
    • FEASSON Léonard
    • Sub-Investigator: Clément FOSCHIA, MD
    • Contact: Léonard FEASSON, PhD; Phone Number: 33 04 77 12 03 83; Email: leonard.feasson@univ-st-etienne.fr
    • Contact: Diana RIMAUD, science Doctor; Phone Number: 33 0477120467; Email: diana.rimaud@chu-st-etienne.fr
    • Principal Investigator: Léonard FEASSON, PhD

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Volunteer who signed the written consent form.
• Man or woman.
• Aged 18-50.
• Physically active and running at least one session of more than one hour per week.
• Haven't participated in any competition in the month before the first visit.
• Not participating in any competition during the study.
• Usual sleep time between 6h-8h per night.

Exclusion Criteria:

• - Any chronic pathology.
• Working night shift.
• Having sleep disorders: score > 5 at Pittsburg Sleep Quality Index.
• Excessive sleepiness: score >10 at Epworth Sleepiness scale.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: REP (reproducibility).; This group will perform an incremental running test, driven to exhaustion, after a night of total sleep deprivation twice, at least two weeks apart.	Other: Reproductibility; This group will perform an incremental running test, driven to exhaustion, after a night of total sleep deprivation twice, at least two weeks apart.
Experimental: PT (total sleep deprivation).; This group will perform an incremental running test, conducted until exhaustion, in: a control condition (usual sleep); a one-night condition of partial sleep deprivation; a one-night partial sleep deprivation condition with 5 nights of prior extension. The order of conditions will be randomized.	Other: Total sleep deprivation; This group will perform an incremental running test, conducted until exhaustion, in: - a control condition (usual sleep) - a one-night condition of partial sleep deprivation - a one-night partial sleep deprivation condition with 5 nights of prior extension. The order of conditions will be randomized.
Experimental: PP (partial sleep deprivation); This group will perform an incremental running test, run to exhaustion, in : a control condition (usual sleep),; a one-night total sleep deprivation condition; a one-night total sleep deprivation condition with 5 nights of extension beforehand. The order of conditions will be randomized.	Other: partial sleep deprivation; This group will perform an incremental running test, conducted until exhaustion, in: - a control condition (usual sleep) - a one-night condition of partial sleep deprivation - a one-night partial sleep deprivation condition with 5 nights of prior extension. The order of conditions will be randomized.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Performance over a standardized incremental running test	Sporting performance, measured by the duration of exercise in a time-limited incremental effort test in running to exhaustion, i.e. the inability to maintain the imposed pace.	Day 7

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Reproducibility of sleep deprivation effects.	Repeatability of sleep deprivation effects will be assessed within the REP group by comparing performance on the time limit test (in minutes) after each sleep deprivation.	Day 7
Resistance to sleep deprivation and genetic polymorphism	The influence of genetic polymorphism will be evaluated via the effects of sleep deprivation according to the genetic polymorphism of the ADORA2A, TNFα and COMT genes	DAy 1
Fatigue (objective and subjective, )	Neuromuscular fatigue will be assessed by the loss of isometric knee extensor muscle strength measured before and just after the time limit test. To characterize the origin of neuromuscular fatigue, electrically evoked forces from peripheral nerve stimulation and electrical muscle activity (EMG) will be measured to quantify central and peripheral fatigue.	DAy 7
Fatigue (sleepiness)	Sleepiness will be assessed using the Epworth Sleepiness Scale, and perceived exertion will be rated on a Borg scale from 6 to 20 during submaximal exercise prior to the time limit test, and regularly during the test.	DAy 7
Fatigue (perception of effort)	Perceived fatigue will be rated on a 0-10 scale before and after the time limit test.	DAy 7
Motor function (running biomechanics )	Motor function will be assessed during 40 minutes of submaximal exercise at an intensity corresponding to the first ventilatory threshold (SV1) preceding the time limit test. Running biomechanics will be investigated by measuring ground reaction forces (in Newtons) using force platforms integrated into an instrumented treadmill.	Day 7
Motor function (energy cost)	Motor function will be assessed during 40 minutes of submaximal exercise at an intensity corresponding to the first ventilatory threshold (SV1) preceding the time limit test. The energy cost of running (Cr, in J/kg/m) will be quantified by measuring gas exchanges over a 5-minute period.	Day 7
Cognitive function (vigilance)	Cognitive function will be assessed before, during and after exercise using Psychomotor Vigilance Task (PVT)	Day 7
Cognitive function (attention)	Cognitive function will be assessed before, during and after exercise using concentration test (sustained attention task).	Day 7
Cognitive function (inhibition)	Cognitive function will be assessed before, during and after exercise using a battery of tests including inhibition test (Go-no Go task)	Day 7

Collaborators and Investigators

• Sponsor: Centre Hospitalier Universitaire de Saint Etienne
• Collaborators: Jean Monnet University
• Investigators: Principal Investigator: Frédéric ROCHE, PhD, CHU Saint-Etienne

Study record dates

Study Major Dates

• Study Start (Actual): June 12, 2025
• Primary Completion (Estimated): January 1, 2028
• Study Completion (Estimated): March 1, 2028

Study Registration Dates

• First Submitted: March 28, 2025
• First Submitted That Met QC Criteria: April 7, 2025
• First Posted (Actual): April 15, 2025

Study Record Updates

• Last Update Posted (Actual): June 17, 2025
• Last Update Submitted That Met QC Criteria: June 13, 2025
• Last Verified: June 1, 2025

More Information

Terms related to this study

• Keywords: Fatigue; Sleep deprivation; Sleep extension; Endurance running
• Additional Relevant MeSH Terms: Neurologic Manifestations; Nervous System Diseases; Mental Disorders; Sleep Wake Disorders; Dyssomnias; Sleep Deprivation
• Other Study ID Numbers: 24CH296; 2024-A02857-40 (Other Identifier: ANSM)

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: this study involves a small number of subjects and is taking place only in ST-ETIENNE

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No