Efficacy of Different Types of Chemical Peels in the Treatment of Acne Vulgaris (AV)

November 19, 2025 updated by: Nahla Maher Mahmoud Mahran

Assessment of the Efficacy and Safety of 50% Glycolic Acid, 30% Salicylic Acid, and Modified Jessner's Chemical Peels in the Treatment of Active Acne and Post-acne Hyperpigmentation: Randomized Controlled Trial

Assessment of the Efficacy and Safety of 50% Glycolic Acid, 30% Salicylic Acid, and Modified Jessner's Chemical Peels in the Treatment of Active Acne and Post-acne Hyperpigmentation: Randomized Controlled Trial.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

90

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Egypt
      • Cairo, Egypt, 13114
        • Cairo University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Facial active acne (mild and moderate cases)
  • post-acne hyperpigmentation
  • a minimum age of 18 years
  • skin phototype III or IV

Exclusion Criteria:

  • Pregnant or nursing women
  • active infection in the treatment area (e.g., verrucae and herpes simplex)
  • systemic disease (hypertension, diabetes, or bleeding tendency)
  • systemic retinoid or laser treatment within the last 6 months
  • history of keloidal tendency or Aspirin sensitivity.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Triple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: glycolic acid group
30 patients received 50% glycolic acid peels
Procedure: Glycolic acid peel alone
Using a cotton tip applicator, a single coat of commercially prepared 50% GA peeling agent was evenly applied to the patient's face. Neutralization of the peel was done on reaching uniform erythema (endpoint) within 3-5 minutes. If frosting was observed in any area before the set time or endpoint, the area was neutralized with sodium bicarbonate
Active Comparator: Salicylic acid group
30 patients received Salicylic acid 30%
Procedure: salicylic acid
Using a cotton tip applicator, a single coat of commercially prepared 30% SA peeling agent was evenly applied to the patient's face, moving from the forehead and advancing to the cheeks, chin, glabella, nose, and perioral area. Once white crystallization appeared, patients were asked to wash their faces with water.
Active Comparator: Modified Jessener group
30 patients received MJ peel
Procedure: modified jessener
Commercially prepared MJ peel was applied using a gauze piece and light hand pressure. A single coat of peel was uniformly applied over the entire face. The coat was allowed to dry completely until erythema or frosting occurred, at which point patients were asked to wash their faces with cold water.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
improvement in acne vulgaris by assessing Global acne scoring system and post-acne hyperpigmentation index
Time Frame: 6 months
6 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Nahla Maher Mahmoud Mahran

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

March 9, 2024

Primary Completion (Actual)

June 10, 2024

Study Completion (Actual)

July 12, 2024

Study Registration Dates

First Submitted

November 16, 2025

First Submitted That Met QC Criteria

November 19, 2025

First Posted (Actual)

November 20, 2025

Study Record Updates

Last Update Posted (Actual)

November 20, 2025

Last Update Submitted That Met QC Criteria

November 19, 2025

Last Verified

November 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • MS-327-2023

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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