Pilot RCT of Computer-based Eye Movement Training (CRYSTAL)

August 3, 2026 updated by: Glasgow Caledonian University

Computer-based Eye Movement Training for Stroke-related Visual Field Loss: a Pilot Randomised Controlled Trial

The goal of this study is to learn whether NeuroEyeCoach, a computer-based eye movement training programme, can help stroke survivors with visual field loss. The study will also assess whether a larger clinical trial is feasible. The main questions it aims to answer are:

  • Can stroke survivors be successfully recruited, randomised and followed up in a larger trial?
  • Is NeuroEyeCoach acceptable and practical to use?
  • Is there early evidence that NeuroEyeCoach improves vision-related functioning and wellbeing? Researchers will compare NeuroEyeCoach plus usual care with usual care alone.

Participants will:

  • Be randomly assigned to receive NeuroEyeCoach plus usual care or usual care alone
  • Complete six weeks of training if allocated to NeuroEyeCoach
  • Complete questionnaires and tests of vision, daily activities, quality of life, confidence and wellbeing
  • Take part in follow-up assessments over six months This pilot trial will include 60 stroke survivors living with visual field loss after stroke. Findings will be used to inform the design of a larger study.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

60

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • adult (>18 years)
  • stroke survivor
  • stroke-related homonymous VFL (minimum quadrantanopia)
  • sufficient language, cognitive, and upper limb ability to participate in trial activities.

Exclusion Criteria:

  • pre-existing (ie pre-stroke) registration as sight impaired (partially sighted) or severely sight impaired (blind)
  • • history of seizure disorders, especially those of a photosensitive nature

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Other
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Eye movement training + usual care
Usual post-stroke care, plus eye movement training (VISIOcoach)
Device: NeuroEyeCoach eye movement training
computer based eye movement training for visual field loss in stroke
Other: Usual Care
Usual post-stroke care
Other: usual care
Usual post-stroke care
Other: Usual Care
Usual post-stroke care

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Recruitment rate
Time Frame: through study completion, estimated at 15 months
Rate of recruitment to the trial
through study completion, estimated at 15 months

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Retention Rate
Time Frame: through study completion, estimated at 15 months
Rate of retention of participants in the study
through study completion, estimated at 15 months
Screening and eligibility rate
Time Frame: Active screening period
Screening and eligibility rate
Active screening period
Outcome measure completion rate
Time Frame: over data collection period
through study completion, estimated at 15 months
over data collection period
intervention adherence
Time Frame: 6 weeks
adherence to recommended training regime (duration)
6 weeks
Adverse events
Time Frame: up to 6 weeks
any adverse eventa experienced
up to 6 weeks
Support and computer provision needs
Time Frame: up to 6 weeks
To what extent must technical equipment or assistance be given
up to 6 weeks
NEI VFQ 25 (National Eye Institute Visual Function Questionnaire-25)
Time Frame: baseline, 6 weeks post randomisation, 6 months post randomisation
Patient-reported measure of vision-related functioning. Minimum value is 0, and maximum value is 100; higher scores mean a better outcome
baseline, 6 weeks post randomisation, 6 months post randomisation
EQ-5D 5L
Time Frame: baseline, 6 weeks post randomisation, 6 months post randomisation
Generic health related quality of life Maximum value 1.0; better scores mean a better outcome
baseline, 6 weeks post randomisation, 6 months post randomisation
IReST (International Reading Speed Test)
Time Frame: baseline, 6 weeks post randomisation, 6 months post randomisation
Reading test (words per minute)
baseline, 6 weeks post randomisation, 6 months post randomisation
Melbourne Rapid Fields
Time Frame: baseline, 6 weeks post randomisation, 6 months post randomisation
visual field test
baseline, 6 weeks post randomisation, 6 months post randomisation
Confidence after Stroke Measure
Time Frame: baseline, 6 weeks post randomisation, 6 months post randomisation
Validated questionnaire that explores self-confidence, positive attitude and social confidence Minimum score is 0 and the maximum score is 81; a higher score indicates better outcome Ref: Horne JC, Lincoln NB, Logan PA. Measurement of confidence: the development and psychometric evaluation of a stroke-specific, measure of confidence. Clin Rehabil. 2017 Nov;31(11):1529-1537. doi: 10.1177/0269215517705424. Epub 2017 May 3. PMID: 28466669; PMCID: PMC5652651.
baseline, 6 weeks post randomisation, 6 months post randomisation
Warwick-Edinburgh Mental Wellbeing Scale
Time Frame: baseline, 6 weeks post randomisation, 6 months post randomisation
Mental wellbeing questionnaire Minimum raw score is 7 and the maximum raw score is 35; higher score means a better outcome
baseline, 6 weeks post randomisation, 6 months post randomisation
health care resource use
Time Frame: baseline, 6 weeks post randomisation, 6 months post randomisation
health care resource use, covering general, stroke specific, and vision specific resources
baseline, 6 weeks post randomisation, 6 months post randomisation

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Glasgow Caledonian University

Collaborators

National Health Service, United Kingdom

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

October 1, 2026

Primary Completion (Estimated)

July 31, 2027

Study Completion (Estimated)

July 31, 2027

Study Registration Dates

First Submitted

December 3, 2025

First Submitted That Met QC Criteria

August 3, 2026

First Posted (Actual)

August 7, 2026

Study Record Updates

Last Update Posted (Actual)

August 7, 2026

Last Update Submitted That Met QC Criteria

August 3, 2026

Last Verified

August 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • HLS/LS/25/032
  • TCS/24/40 (Other Grant/Funding Number: Chief Scientist Office Scotland)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

IPD Plan Description

We have not yet discussed and decided our IPD sharing position

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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