Clinical Trials on Cortical Development Malformation in South Africa

Total 336 results

GRIN Therapeutics, Inc.

Recruiting

A Study of Radiprodil on Safety, Tolerability, Pharmacokinetics, and Effect on Seizures and Behavioral Symptoms in Patients With TSC or FCD Type II

Tuberous Sclerosis Complex | Focal Cortical Dysplasia

Spain, United Kingdom, Australia, Belgium, Canada, Italy, Poland
The University of Texas Health Science Center,...

Completed

Topical Rapamycin to Erase Angiofibromas in TSC (Treatment)

Tuberous Sclerosis | Angiofibromas

United States, Australia
Medical University of South Carolina

Recruiting

Weekly Sirolimus Therapy

Lymphatic Malformation | Venous Malformation

United States
Noema Pharma AG

Recruiting

Basimglurant in Children, Adolescents, and Young Adults With TSC

Tuberous Sclerosis Complex

United States, India, Israel, Turkey, Italy, Poland, Spain, United Kingdom
Novartis Pharmaceuticals

Active, not recruiting

Roll-over Study to Collect and Assess Long-term Safety of Everolimus in Patients With TSC and Refractory Seizures Who Have Completed the EXIST-3 Study [CRAD001M2304] and Who Are Benefitting From Continued Treatment

Tuberous Sclerosis Complex

United States, Spain, Belgium, Taiwan, Turkey, Australia, Korea, Republic of, Thailand, France, Hungary, United Kingdom, Italy, Japan, Canada, Russian Federation, Poland, Mexico, Colombia
Marinus Pharmaceuticals

Enrolling by invitation

Open-label Study of Adjunctive GNX Treatment in Children and Adults With TSC-related Epilepsy

Tuberous Sclerosis Complex

United States, Spain, United Kingdom, China, Italy, France, Israel, Germany, Canada, Australia
Marinus Pharmaceuticals

Active, not recruiting

Adjunctive GNX Treatment Compared With Placebo in Children and Adults With TSC-related Epilepsy (TrustTSC)

Tuberous Sclerosis Complex

United States, Spain, United Kingdom, Israel, Italy, Germany, France, Canada
Georgia State University
National Institute on Deafness and Other Communication Disorders (NIDCD); University...

Completed

Communication Outcomes for South African Children With Developmental Disabilities

Developmental Disability

South Africa
Novartis Pharmaceuticals

Completed

A Placebo-controlled Study of Efficacy & Safety of 2 Trough-ranges of Everolimus as Adjunctive Therapy in Patients With Tuberous Sclerosis Complex (TSC) & Refractory Partial-onset Seizures (EXIST-3)

Tuberous Sclerosis Complex-associated Refractory Seizures

United States, Colombia, Belgium, France, Japan, Taiwan, Turkey, Spain, Thailand, Korea, Republic of, Australia, Hungary, United Kingdom, Canada, Norway, Germany, Italy, Russian Federation, Denmark, Argentina, Netherlands, Greece, P... and more
Jazz Pharmaceuticals

Active, not recruiting

Assessment of Potential for Chronic Liver Injury in Participants Treated With Epidiolex (Cannabidiol) Oral Solution

Tuberous Sclerosis Complex | Dravet Syndrome | Lennox Gastaut Syndrome

United States
University of Johannesburg

Completed

The Effect of Individualised Homoeopathic Treatment of Autism Spectrum Disorder in Children

Autism Spectrum Disorder

South Africa
University of Witwatersrand, South Africa

Unknown

A Comparison of Immediate Treatment of CIN1 With Cryotherapy and 12 Month Cytology Follow up in HIV Seropositive Women

Cervical Dysplasia

South Africa
Novartis Pharmaceuticals

Completed

Efficacy and Safety of Everolimus (RAD001) in Patients of All Ages With Subependymal Giant Cell Astrocytoma Associated With Tuberous Sclerosis Complex (TSC)(EXIST-1) (EXIST-1)

Tuberous Sclerosis | Subependymal Giant Cell Astrocytoma

United States, Belgium, Canada, Germany, Italy, Russian Federation, Netherlands, Poland, Australia, United Kingdom
Antiva Biosciences

Completed

Study of Topical ABI-1968 in Subjects With Precancerous Cervical Lesions From Human Papillomavirus (HPV) Infection.

Cervical Cancer | Human Papilloma Virus | HSIL, High Grade Squamous Intraepithelial Lesions | Cervical Dysplasia | HSIL of Cervix | High-Grade Cervical Intraepithelial Neoplasia | HIV Negative | CIN - Cervical Intraepithelial Neoplasia | Cervical Neoplasm

South Africa
UNC Lineberger Comprehensive Cancer Center
Fogarty International Center of the National Institute of Health

Completed

Finding Barriers and Designing Solutions to Promote Women s Cancer Screening in South Africa (FIND)

Cervical Cancer

South Africa
UNC Lineberger Comprehensive Cancer Center
National Cancer Institute (NCI)

Recruiting

Urine HPV Testing for Cervical Cancer Screening Among Women Living With HIV in South Africa

Cervical Cancer | CIN2 | CIN3

South Africa
Jeffrey Kotzen
National Research Foundation of South Africa; NTP Radioisotopes SOC Ltd

Unknown

Modulated Electro-Hyperthermia Plus Chemo-radiation for Locally Advanced Cervical Cancer Patients in South Africa (mEHT)

Cervical Cancer

South Africa
University of Pretoria
University of Stellenbosch

Recruiting

Screening Study for Cervical Pre-cancer and Cancer Prevention in South African Women. (DiaVACCS)

Cervical Cancer | CIN2 | High Grade Sil

South Africa
Columbia University
Bill and Melinda Gates Foundation; University of Cape Town; EngenderHealth

Terminated

Screen and Treat for Cervical Cancer Prevention (SAT)

Cervical Cancer

South Africa
University of Witwatersrand, South Africa

Completed

Validation of Implementation of Cervical Dysplasia Treatment Modalities in HIV-Seropositive Women (VICAR2)

Cervical Intraepithelial Neoplasia

South Africa
University of Cape Town
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Recruiting

B. Infantis Supplementation to Improve Immunity in Infants Exposed to HIV (BifIID)

Vaccine Reaction | Hiv | Microbial Colonization | Infant Development

South Africa
Duke University
National Institute of Mental Health (NIMH); University of Cape Town

Completed

Tailoring Treatment Targets for Early Autism Intervention in Africa

Autism Spectrum Disorder

South Africa
UNC Lineberger Comprehensive Cancer Center
National Cancer Institute (NCI)

Recruiting

Acceptability and Feasibility of Combination Treatment for Cervical Precancer Among South African Women Living With HIV (ACT2)

Cervical Cancer | Human Immunodeficiency Virus | Human Papillomavirus | CIN2 | CIN3

South Africa
Maastricht Radiation Oncology

Completed

Predicting Outcome in Cervix Carcinoma: a Prospective Study (POCER)

Cervical Cancer

Netherlands, South Africa
Duke University
University of Cape Town

Completed

Pilot Study to Improve Access to Early Intervention for Autism in Africa

Autism Spectrum Disorder

South Africa
Duke University
University of Cape Town

Recruiting

Autism Caregiver Coaching in Africa (ACACIA)

Autism or Autistic Traits

South Africa
Chris Hani Baragwanath Academic Hospital
Masimo Corporation

Completed

Usefulness of Non-invasive Pulse Co-oximetry Haemaglobin Measurements in Critically Ill Black Patients

Critically Ill Black Patients

South Africa
ANRS, Emerging Infectious Diseases

Completed

Infant Peri-Exposure Prophylaxis to Prevent HIV-1 Transmission by Breastfeeding: Mechanisms & Safety

Growth and Development

Burkina Faso, South Africa, Uganda, Zambia
University of Stellenbosch
Fresenius Kabi

Recruiting

Effect of Combined IV Bolus Amino Acid Supplementation and Mobilisation on Muscle Mass in Patients Over the First Week of ICU Care: RCT

Critical Illness

South Africa
AIDS Malignancy Consortium
National Cancer Institute (NCI); Montefiore Medical Center; University of Arkansas and other collaborators

Completed

Cisplatin and Radiation Therapy in Treating Patients With HIV-Associated Locally Advanced Cervical Cancer

Acquired Immunodeficiency Syndrome | Cervical Cancer

South Africa, Zimbabwe
DePuy International

Terminated

A Single Centre Study to Assess the Long-term Performance of the DePuy ASR™ System in Primary Hip Resurfacing Surgery

Osteoarthritis | Rheumatoid Arthritis | Avascular Necrosis | Post-traumatic Arthritis | Congenital Hip Dysplasia | Slipped Capital Femoral Epiphysis | Collagen Disorders | Nonunion of Femoral Fractures

South Africa
AIDS Malignancy Consortium
National Cancer Institute (NCI); University of Arkansas; The Emmes Company, LLC; University of Stellenbosch

Withdrawn

Testing the Addition of Paclitaxel and Carboplatin Given After Standard Chemotherapy and Radiation for Cervical Cancer in HIV-positive Women

HIV Infection | Cervical Adenocarcinoma | Cervical Adenosquamous Carcinoma | Cervical Squamous Cell Carcinoma, Not Otherwise Specified | FIGO Stage IIB Cervix Carcinoma | FIGO Stage III Cervix Carcinoma | FIGO Stage IVA Cervix Carcinoma

South Africa, Zimbabwe
Antiva Biosciences

Recruiting

A Study of ABI-2280 Vaginal Tablet in Participants With Cervical Intraepithelial Neoplasia

Cervical Intraepithelial Neoplasia

Australia, South Africa
University of KwaZulu

Completed

Co Morbid Attention Deficit and Hyperactivity Disorder(ADHD) and Developmental Co Ordination Disorder (DCD)

Developmental Coordination Disorder | Attention Deficit Disorder With Hyperactivity

South Africa
Boston University Charles River Campus
Massachusetts General Hospital; University of Witwatersrand, South Africa

Not yet recruiting

Identifying and Addressing Barriers to Retention in the Cervical Cancer Treatment Cascade Among Women With HIV in South Africa: Part 2

Cervical Cancer | Hiv

United States, South Africa
Beacon Hill Academy
Anglia Ruskin University; The Music Therapy Charity Ltd

Withdrawn

Improvised Music to Enhance Intensive Interaction Version 1

Child Development Disorders, Specific | Developmental Communication Disorders

United Kingdom
GlaxoSmithKline
University of Cape Town; African Organization for Research and Training in...

Completed

Type Distribution of Human Papillomavirus in Adult African Women Diagnosed With Invasive Cervical Cancer

Cervical Cancer | Infections, Papillomavirus

Ghana, Nigeria, South Africa
Seoul National University Hospital
Asan Medical Center; Johannes Gutenberg University Mainz; Gyeongsang National... and other collaborators

Active, not recruiting

CoHOrt of Cerebral CavernOus maLformATion: multicEnter Prospective Observational Study (CHOCOOATE)

Intracerebral Hemorrhage | Cerebral Cavernous Malformation

Korea, Republic of
University of California, Los Angeles
University of Stellenbosch; The ELMA Foundation; Philani Maternal Child Health...

Completed

Evaluation of a Home-based Community Health Worker Program in Rural Eastern Cape, South Africa

Depression | HIV Infections | Alcohol Drinking | Alcohol; Harmful Use | HIV/AIDS | Depressive Symptoms | Child Development | Alcohol Use Disorder | Stunting | Child Nutrition Disorders | Child Malnutrition | Birth Weight Less Than 10Th Percentile

South Africa
International Atomic Energy Agency

Unknown

Clinical and Experimental Studies to Improve Radiotherapy Outcome in AIDS Cancer Patients

Cancer of the Cervix

India, South Africa, Tanzania, Uganda, Zimbabwe
AIDS Malignancy Consortium
National Cancer Institute (NCI); University of California, Los Angeles; Merck... and other collaborators

Active, not recruiting

HPV Vaccine Therapy in Reducing High-Grade Cervical Lesions in Patients With HIV and HPV (COVENANT)

HIV Infection | AIDS-Related Human Papillomavirus Infection | High Grade Cervical Squamous Intraepithelial Neoplasia

Uganda, Kenya, Zimbabwe, South Africa, Malawi
Forest Laboratories

Completed

Withdrawal Study of Memantine in Pediatric Patients With Autism, Asperger's Disorder, or Pervasive Developmental Disorder Not Otherwise Specified Previously Treated With Memantine

Autistic Disorder | Autism | Autism Spectrum Disorders | Asperger Syndrome | Asperger's Disorder | Pervasive Developmental Disorder - Not Otherwise Specified (PDD-NOS)

United States, Belgium, Colombia, Estonia, France, Hungary, Iceland, Italy, Korea, Republic of, New Zealand, Poland, Serbia, South Africa, Spain, Ukraine
University of Sheffield
University of Liverpool; University of Manchester; University of Melbourne

Active, not recruiting

Do Video Materials Help Parents to Support Infant Development?

Language Development

United Kingdom
University of Sheffield

Completed

How Parents Can Help Babies Learn to Talk With Picture Books.

Language Development

United Kingdom
University of Sheffield
University of Leeds

Completed

Supporting Children's School Readiness.

Language Development

United Kingdom
Quadrant Biosciences Inc.
Children's Hospital of Philadelphia; University of Pittsburgh; Emory University; Seattle Children's Hospital and other collaborators

Recruiting

Validation of a Salivary miRNA Diagnostic Test for ASD

Autism Spectrum Disorder | Developmental Delay

United States
Avera McKennan Hospital & University Health Center

Completed

Effects of Music Intervention on the Brain Development of Preschool Children

Child Development

United States
Foundation for the National Institutes of Health
Johns Hopkins University; Aga Khan University; Penn State University; University... and other collaborators

Unknown

Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED)

Immune Response | Diarrhea | Malnutrition | Wasting | Stunting | Cognitive Development

India, Pakistan, Bangladesh, Brazil, Nepal, Peru, South Africa, Tanzania
Forest Laboratories

Completed

An Open-Label Safety Study of Memantine in Pediatric Patients With Autism, Asperger's Disorder, or Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS)

Autistic Disorder | Autism | Asperger's Disorder | Autism Spectrum Disorder (ASD) | Asperger's | Pediatric Autism | Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS)

United States, Belgium, Colombia, Estonia, Hungary, Iceland, Italy, Korea, Republic of, New Zealand, Poland, Serbia, South Africa, Spain, Ukraine, Australia, Canada, France, Singapore
Forest Laboratories

Terminated

Safety Study of Memantine in Pediatric Patients With Autism, Asperger's Disorder or Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS)

Autistic Disorder | Autism | Asperger's Disorder | Autism Spectrum Disorder (ASD) | Asperger's | Pediatric Autism | Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS)

United States, Estonia, Hungary, Iceland, Italy, Korea, Republic of, Serbia, Ukraine, Canada, Colombia, Belgium, France, New Zealand, Poland, South Africa, Spain

Clinical Trials on Cortical Development Malformation in South Africa

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