Clinical Trials on GLP-1 in South Africa

Total 290 results

Johns Hopkins Bloomberg School of Public Health
University of California, San Francisco; University of Toronto; National Institute... and other collaborators

Completed

HIV Treatment Retention Interventions for Women Living With HIV (Siyaphambili Study)

HIV-1 Virologic Response

South Africa
Professor Francois Venter

Recruiting

ADORE: Efficacy of DORavirine in Adults Living With HIV Experiencing Virological Failure on First-line Efavirenz-based Antiretroviral Therapy With NNRTI Resistance (ADORE)

HIV-1-infection

South Africa
Professor Francois Venter

Completed

ADVANCE Study of DTG + TAF + FTC vs DTG + TDF + FTC and EFV + TDF+FTC in First-line Antiretroviral Therapy (ADVANCE)

HIV-1 Infection

South Africa
Gilead Sciences

Completed

Rollover Study Protocol for Pediatric Patients in South Africa for Continued Access to Emtricitabine

HIV-1 Infection

South Africa
Gilead Sciences

Active, not recruiting

Study of VRC07-523LS, CAP256V2LS, and Vesatolimod, in Early Antiretroviral-treated HIV-1 Clade C-infected Women

HIV-1-infection

South Africa
Emory University
National Institute of Mental Health (NIMH); University of KwaZulu

Completed

InTSHA: Interactive Transition Support for HIV-infected Adolescents Using Social Media (InTSHA)

HIV-1-infection | Adolescent Behavior

South Africa
International AIDS Vaccine Initiative
ModernaTX, Inc.; AURUM Tembisa Clinical Research; Center for Family Health Research

Active, not recruiting

A Study to Evaluate the Safety and Immunogenicity of eOD-GT8 60mer mRNA Vaccine (mRNA-1644)

HIV-1-infection

Rwanda, South Africa
University of KwaZulu
Medical Research Council, South Africa; Centre for the AIDS Programme of Research...

Completed

Immediate or Deferred Pre-exposure Prophylaxis for HIV Prevention: Safe Options for Pregnant and Lactating Women (PrEP)

HIV-1-infection

South Africa
International Partnership for Microbicides, Inc.
Gilead Sciences

Withdrawn

Reversing the Epidemic in Africa With Choices in HIV Prevention (REACH)

HIV-1-infection

South Africa
Professor Francois Venter

Completed

DORA: A Doravirine-based First-line Antiretroviral Therapy for Women of Reproductive Potential Living With HIV (DORA)

HIV-1-infection

South Africa
Professor Francois Venter
Merck Sharp & Dohme LLC; Africa Health Research Institute

Recruiting

A Randomised, Phase 3 Non-inferiority Study of DOR/3TC/TDF Compared to DTG/TAF/FTC in Participants Infected With HIV-1 Starting First-line Antiretroviral Therapy (Opti-DOR)

HIV-1-infection

South Africa
University of California, Los Angeles
University of Cape Town

Completed

Postpartum Pre-exposure Prophylaxis (PrEP) Study to Evaluate an Adherence Promotion Package for Postpartum Women on PrEP (PPS)

HIV-1-infection

South Africa
Lannett Company, Inc.
Parexel; FARMOVS (Pty) Ltd

Completed

A Study to Demonstrate Pharmacokinetic and Pharmacodynamic Biosimilarity Between HEC-Glargine and US-Lantus® in Healthy Male Volunteers

Type 2 Diabetes Mellitus | Type 1 Diabetes Mellitus

South Africa
Professor Francois Venter
University of Cape Town

Completed

The Effect of Rifampicin on the Pharmacokinetics of Intracellular Tenofovir-diphosphate and Tenofovir When Coadministered With Tenofovir Alafenamide Fumarate During the Maintenance Phase of Tuberculosis Treatment in TB/HIV-1 Coinfected Participants (EpiTAF)

Tuberculosis | HIV-1-infection

South Africa
Foundation for Innovative New Diagnostics, Switzerland
University of Cape Town; The Leona M. and Harry B. Helmsley Charitable Trust; University of Pretoria

Recruiting

Use of Continuous Glucose Monitoring Devices Among People Living With Type 1 Diabetes in South Africa (ACCEDE)

Type 1 Diabetes

South Africa
Medical University of South Carolina

Completed

Effects of GLP-1 Agonists on Gastric Volume

Diabetes | Glucagon-like Peptide 1 | GLP-1 | Gastric Content Aspiration

United States
Massachusetts General Hospital
Harvard Medical School (HMS and HSDM); National Institute of Allergy and Infectious... and other collaborators

Completed

Population Effectiveness of Dolutegravir Implementation in Sub-Saharan Africa (DISCO)

HIV-1-infection

Uganda, South Africa
Africa Health Research Institute

Recruiting

Thetha Nami Ngithethe Nawe ("Let's Talk"): Step Wedge cRCT of Peer Led Community PrEP and SRH for Youth in South Africa

Sexually Transmitted Diseases | HIV-1-infection

South Africa
University of Liverpool
Radboud University Medical Center; University of Cape Town; UNITAID; Liverpool... and other collaborators

Completed

Dolutegravir in Pregnant HIV Mothers and Their Neonates (DolPHIN-2)

Pregnancy Related | HIV-1-infection

Uganda, South Africa
University of Washington
National Institute of Allergy and Infectious Diseases (NIAID); Centre for the...

Recruiting

Simplifying Treatment and Monitoring for HIV (STREAM HIV)

HIV/AIDS | HIV-1-infection

South Africa
Novo Nordisk A/S

Completed

Long Term Safety of Biphasic Insulin Aspart 30 in Juveniles With Type 1 Diabetes

Diabetes | Diabetes Mellitus, Type 1

South Africa
Yaounde Central Hospital
University of Exeter; University of Yaounde 1; MRC/UVRI & LSHTM Uganda Research...

Recruiting

Characteristics of Young-onset Diabetes in Sub-Saharan Africa (YODA) Study (YODA)

Type 1 Diabetes | Diabetes, Autoimmune

Tanzania, Cameroon, South Africa, Uganda
AIDS Clinical Trials Group
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

PK Study of Rifampicin Interactions With DMPA and Efavirenz in TB (PRIDE-HT)

Tuberculosis | HIV-1 Infection

South Africa, Zimbabwe, Botswana, Kenya
International Maternal Pediatric Adolescent AIDS...
National Institute of Allergy and Infectious Diseases (NIAID); Eunice Kennedy... and other collaborators

Recruiting

Group-Based Intervention to Improve Mental Health and Adherence Among Youth Living With HIV in Low Resource Settings

HIV-1-infection

Zimbabwe, Botswana, Malawi, South Africa
MRC/UVRI and LSHTM Uganda Research Unit
Janssen Pharmaceuticals

Recruiting

Improving HIV-1 Control in Africa With Long Acting Antiretrovirals (IMPALA)

HIV-1-infection

South Africa, Kenya, Uganda
International AIDS Vaccine Initiative
Brigham and Women's Hospital; Fred Hutchinson Cancer Center; Rockefeller University

Active, not recruiting

Safety and Pharmacokinetics of the Combination Broadly Neutralizing Antibodies, 3BNC117-LS-J and 10-1074-LS-J, in Healthy American and African Adults

HIV-1-infection

United States, Uganda, Kenya, Rwanda, South Africa
Janssen Vaccines & Prevention B.V.

Terminated

A Study to Assess the Efficacy of a Heterologous Prime/Boost Vaccine Regimen of Ad26.Mos4.HIV and Aluminum Phosphate-Adjuvanted Clade C gp140 in Preventing Human Immunodeficiency Virus (HIV) -1 Infection in Women in Sub-Saharan Africa

HIV-1

South Africa, Malawi, Mozambique, Zambia, Zimbabwe
National Institute of Allergy and Infectious Diseases...

Not yet recruiting

CREATE - Cabotegravir & Rilpivirine Antiretroviral Therapy in Pregnancy

Pregnancy | HIV-1-infection | Postpartum

United States, South Africa
Gilead Sciences

Active, not recruiting

Study To Evaluate Emtricitabine/Tenofovir Alafenamide (F/TAF) in Human Immunodeficiency Virus 1 (HIV-1) Infected Children and Adolescents Virologically Suppressed on a 2- Nucleoside/Nucleotide Reverse Transcriptase Inhibitor (2-NRTI)-Containing Regimen

HIV-1

United States, Panama, South Africa
AIDS Clinical Trials Group
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Gentian Violet Vs. Nystatin Oral Suspension for Treatment of Oropharyngeal Candidiasis

HIV-1 Infection

Kenya, Malawi, Uganda, South Africa, Zimbabwe, Botswana, India
AIDS Clinical Trials Group
National Cancer Institute (NCI); National Institute of Allergy and Infectious... and other collaborators

Completed

Three Chemo Regimens as an Adjunct to ART for Treatment of Advanced AIDS-KS

HIV-1 Infection

South Africa, Brazil, Zimbabwe, Kenya, Malawi, Uganda
University College, London
London School of Hygiene and Tropical Medicine; MRC/UVRI and LSHTM Uganda Research... and other collaborators

Active, not recruiting

Long-Acting Treatment in Adolescents (LATA) (LATA)

HIV Infections | Hiv | HIV-1-infection | Paediatric Human Immunodeficiency Virus Infection

Uganda, Zimbabwe, Kenya, South Africa
AIDS Clinical Trials Group
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

HPV Test-and-Treat-Strategy Versus Cytology-based Strategy for Prevention of CIN2+ in HIV-Infected Women

HIV-1 Infection

Peru, Malawi, South Africa, Zimbabwe, Haiti, Botswana, India
University of Cape Town

Completed

Linezolid, Aspirin and Enhanced Dose Rifampicin in HIV-TBM (LASER-TBM)

HIV-1-infection | Tuberculosis Meningitis

South Africa
Janssen Sciences Ireland UC

Completed

TMC114IFD3001 - Study Providing Continued Access to Treatment With Darunavir (DRV)/Ritonavir(Rtv) in HIV1 Infected Adults, Adolescents and Children Aged 3 Years or Above and Coming From Previous Company Sponsored Studies With DRV

HIV-1 Infections

Costa Rica, Panama, South Africa, Ukraine, Malaysia, Brazil, Thailand, Guatemala
AIDS Clinical Trials Group
National Institute of Allergy and Infectious Diseases (NIAID)

Not yet recruiting

Pausing Antiretroviral Treatment Under Structured Evaluation (PAUSE)

HIV-1-infection

Malawi, South Africa, Botswana
Novo Nordisk A/S

Completed

Safety of Insulin Detemir Produced by a New Process as Measured by Antibody Formation in Subjects With Type 1 Diabetes

Diabetes | Diabetes Mellitus, Type 1

Germany, South Africa, Russian Federation, Former Serbia and Montenegro, North Macedonia
Novo Nordisk A/S

Completed

A Survey on Low Blod Sugar Among Insulin-treated Patients With Diabetes

Diabetes Mellitus, Type 2 | Diabetes | Diabetes Mellitus, Type 1

Turkey, Egypt, Philippines, United Arab Emirates, Bangladesh, Colombia, Singapore, South Africa
Merck Sharp & Dohme LLC

Completed

Safety and Pharmacokinetics of Oral Islatravir (MK-8591) Once Monthly in Participants at Low Risk of Human Immunodeficiency Virus 1 (HIV-1) Infection (MK-8591-016)

HIV-1 Infection

United States, Israel, South Africa
National Institute of Allergy and Infectious Diseases...
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Recruiting

Study of Oral and Long-Acting Injectable Cabotegravir and Rilpivirine in Virologically Suppressed Children Living With HIV-1, Two to Less Than 12 Years of Age

HIV-1-infection

United States, Brazil, South Africa, Uganda, Botswana, Thailand
University of Sheffield
University of Derby

Completed

Feasibility Study of an App-based Intervention to Improve Wellbeing (IWUN)

Mental Health Wellness 1

United Kingdom
AIDS Clinical Trials Group
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Study of Options for Second-Line Effective Combination Therapy (SELECT) (SELECT)

HIV-1 Infection

Peru, Kenya, Malawi, Brazil, South Africa, Zimbabwe, India, Thailand, Tanzania
Novo Nordisk A/S

Completed

Frequency of Hypoglycaemic Episodes During Treatment With Insulin Detemir in Well Controlled Subjects With Type 1 Diabetes

Diabetes | Diabetes Mellitus, Type 1

Denmark, Croatia, Australia, South Africa, Italy, Sweden
Janssen Sciences Ireland UC

Completed

TMC114-TiDP29-C232 - Study Providing Continued Access to Treatment With Darunavir (DRV)/Ritonavir (Rtv) for Children Coming From Any of the Three Ongoing Tibotec Sponsored Pediatric Studies With DRV

HIV-1 Infections

France, Ukraine, South Africa, United Kingdom, Argentina, Brazil, India, Spain
Janssen Sciences Ireland UC

Completed

A Study to Evaluate the Pharmacokinetics, Safety, Tolerability, and Antiviral Activity of Rilpivirine (TMC278) in Human Immunodeficiency Virus Infected Adolescents and Children Aged Greater Than or Equal to 6 Years

HIV-1

United States, South Africa, Ukraine, Kenya, Thailand, India, Romania, Uganda
Pfizer
ViiV Healthcare

Terminated

A Long Term Safety Study Of Lersivirine For The Treatment Of HIV-1 Infection In Subjects Who Have Completed Treatment With Lersivirine In Studies A5271015 And A5271022

HIV-1

South Africa, Australia, United Kingdom, Canada, Italy, Poland, Switzerland, Mexico, Brazil
Novartis Pharmaceuticals

Terminated

Extension to a Randomized, Double-blind, Placebo Controlled Study of LCQ908 in Subjects With Familial Chylomicronemia Syndrome.

Familial Chylomicronemia Syndrome (FCS) (HLP Type I)

South Africa, Germany, United Kingdom, France, United States, Canada, Netherlands
AIDS Clinical Trials Group
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Antiretroviral Therapy (ART) Alone or With Delayed Chemo Versus ART With Immediate Chemo for Limited AIDS-related Kaposi's Sarcoma (REACT-KS)

Kaposi's Sarcoma | HIV-1 Infection

Peru, Kenya, Malawi, Brazil, South Africa, Uganda
Janssen Sciences Ireland UC

Active, not recruiting

A Roll-over Study With Rilpivirine for Human Immunodeficiency Virus Type 1 (HIV-1) Infected Participants Who Participated in Rilpivirine Pediatric Studies

Human Immunodeficiency Virus Type 1

Portugal, South Africa, Thailand, Uganda, Spain
AIDS Clinical Trials Group
National Institute of Allergy and Infectious Diseases (NIAID); United States...

Completed

Assess Therapeutic Efficacy and Emergence of HIV Drug Resistance Following Initiation of TLD

HIV-1-infection

Kenya, South Africa, Haiti, Malawi, Uganda, Zimbabwe

Clinical Trials on GLP-1 in South Africa

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