Clinical Trials on Genetic High Risk for Schizophrenia

Total 15041 results

NYU Langone Health
GlaxoSmithKline

Completed

Lapatinib Study for Children and Adults With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors

Neurofibromatosis 2 | Vestibular Schwannoma

United States
National Taiwan University Hospital
National Cheng-Kung University Hospital

Unknown

Mitochondrial nt3243 A>G Mutation in Taiwan

MELAS Syndrome | Noninsulin-dependent Diabetes Mellitus With Deafness

Taiwan
Avidity Biosciences, Inc.

Recruiting

Phase 1/2 Study of AOC 1020 in Adults With Facioscapulohumeral Muscular Dystrophy (FSHD) (FORTITUDE)

Muscular Dystrophies | Muscular Dystrophy, Facioscapulohumeral | FSHD | Facio-Scapulo-Humeral Dystrophy | FMD | Facioscapulohumeral Muscular Dystrophy 1 | FSHD2 | FSHD1 | FMD2 | Fascioscapulohumeral Muscular Dystrophy | Fascioscapulohumeral Muscular Dystrophy Type 1 | Fascioscapulohumeral Muscular Dystrophy... and other conditions

United States, United Kingdom, Canada
University Hospital Inselspital, Berne

Recruiting

Prognosis of Cerebral Small Vessel Disease - a Prospective Cohort Study (PRO-SVD)

Cerebral Amyloid Angiopathy | Cadasil | Small Vessel Cerebrovascular Disease | CAA - Cerebral Amyloid Angiopathy

Switzerland
Sun Yat-sen University

Recruiting

GM1 Prophylaxis for WBRT Related Cognitive Dysfunction (GLORY)

Breast Cancer | Cognitive Impairment | Brain Metastases | Radiotherapy Side Effect | Gangliosidosis, GM1

China
NYU Langone Health

Recruiting

Cascade Testing in Families With Newly Diagnosed Hereditary Breast and Ovarian Cancer Syndrome

MLH1 Gene Mutation | RAD51C Gene Mutation | BRIP1 Gene Mutation | MSH6 Gene Mutation | PMS2 Gene Mutation | BRCA-Mutated Ovarian Carcinoma | MSH2 A636P | EPCAM

United States
The University of Texas Health Science Center at...
National Institute of General Medical Sciences (NIGMS)

Recruiting

Genetic Analysis of Pheochromocytomas, Paragangliomas and Associated Conditions

Kidney Neoplasms | Bone Cancer | Thyroid Neoplasms | Pheochromocytoma | Paraganglioma | Other Cancer | Inherited Cancer Syndrome | Associated Conditions

United States
Mayo Clinic
Cambridge University Hospitals NHS Foundation Trust

Recruiting

Mayo AVC Registry and Biobank

Heart Diseases | Cardiovascular Diseases | Myocarditis | Cardiomyopathies | Ventricular Tachycardia | Cardiovascular Abnormalities | Sarcoidosis | Sudden Cardiac Death | Cardiac Arrhythmia | Cardiac Sarcoidosis | Sudden Cardiac Arrest | Arrhythmogenic Right Ventricular Cardiomyopathy | Arrhythmogenic Right Ventricular... and other conditions

United States, United Kingdom
Leigh R. Hochberg, MD, PhD.
National Institute of Neurological Disorders and Stroke (NINDS); US Department... and other collaborators

Recruiting

BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia (BrainGate2)

Amyotrophic Lateral Sclerosis | Muscular Dystrophy | Spinal Cord Injuries | Tetraplegia | Brain Stem Infarctions | Locked in Syndrome

United States
Bellicum Pharmaceuticals

Terminated

Safety Study of Gene Modified Donor T Cell Infusion After Stem Cell Transplant for Non-Malignant Diseases

Hemoglobinopathies | Hemophagocytic Lymphohistiocytosis | Metabolic Disorders | Primary Immune Deficiency Disorders | Inherited Bone Marrow Failure Syndrome

United States
University of Alabama at Birmingham
Memorial Sloan Kettering Cancer Center

Active, not recruiting

Phase 2 Clinical Trial of Crizotinib for Children and Adults With Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas (NF110)

Neurofibromatosis 2 | Progressive Vestibular Schwannoma (VS)

United States
Mandos LLC

Completed

VTS-270 to Treat Niemann-Pick Type C1 (NPC1) Disease

Niemann-Pick Disease, Type C

United States, Australia, United Kingdom, Germany, France, New Zealand, Singapore, Spain, Turkey
InSightec

Active, not recruiting

ExAblate Transcranial MRgFUS for the Management of Treatment-Refractory Movement Disorders

Parkinson's Disease | Movement Disorders | Tardive Dyskinesia | Dystonia | Essential Tremor | Huntington's Disease | Wilson's Disease | Holmes Tremor | Orofacial Dyskinesias

Canada
East Kent Hospitals University NHS Foundation Trust
KU Leuven; University of Kent; Sussex Community NHS Foundation Trust; l'Institut...

Completed

An Assistive Powered Wheelchair: Stage 2 Trial (EDUCAT)

Stroke | Multiple Sclerosis | Craniocerebral Trauma | Cystic Fibrosis | Guillain-Barre Syndrome | Motor Neurone Disease

United Kingdom
University of Alabama at Birmingham
Genentech, Inc.

Completed

Phase 2 Study of Bevacizumab in Children and Young Adults With NF 2 and Progressive Vestibular Schwannomas

Neurofibromatosis Type 2 | Progressive Vestibular Schwannomas

United States
Charite University, Berlin, Germany

Unknown

Perfusion Rate Assessment by Near-infrared Fluorescence in Gastrointestinal Anastomoses

Pancreatic Neoplasms | Crohn Disease | Ulcerative Colitis | Familial Adenomatous Polyposis | Diverticulitis | Hepatobiliary Neoplasm | Bowel Obstruction | Cancer of the Gastrointestinal Tract | Stoma Ileostomy | Bowel Ischemia | Abnormality of the Gastrointestinal Tract | Symptomatic Disorders of the Gastrointestinal...

Germany
NYU Langone Health

Completed

Exploring the Activity of RAD001 in Vestibular Schwannomas and Meningiomas

Neurofibromatosis Type 2 | Meningiomas | Vestibular Schwannomas

United States
University of Split, School of Medicine
General Hospital Zadar

Unknown

QoL and Stress in Parents of Children With Developmental Disabilities and Chronic Disease

Epilepsy | Cerebral Palsy | Diabetes Mellitus, Type 1 | Stress | Asthma | Chronic Disease | Autism Spectrum Disorder | Down Syndrome | Developmental Disability | Pervasive Developmental Disorder

Croatia
Acrotech Biopharma Inc.
National Cancer Institute (NCI)

Completed

To Evaluate the Safety, Activity and Pharmacokinetics of Marqibo in Children and Adolescents With Refractory Cancer

Sarcoma | Lymphoma | Leukemia | Neuroblastoma | Brain Tumors | Wilms Tumor

United States
University of Basel
Kantonsspital Aarau

Completed

Prevention of Conversion in Posterior Retroperitoneal Adrenalectomy by Measuring Preoperative Anatomical Conditions

Pheochromocytoma | Adrenal Tumor | Adrenal Mass | Adrenal Hyperplasia | Adrenal Metastases | Conn Adenoma

Switzerland
University Hospital Tuebingen
National Center for Tumor Diseases, Heidelberg

Completed

WES of NF2-associated in Comparison to Sporadic Vestibular Schwannomas - Correlation With Clinical Data (NF2)

Neurofibromatosis Type 2 | Vestibular Schwannoma | Acoustic Neuroma

Germany
Novartis Pharmaceuticals

Completed

Efficacy and Safety of RAD001 in Patients Aged 18 and Over With Angiomyolipoma Associated With Either Tuberous Sclerosis Complex (TSC) or Sporadic Lymphangioleiomyomatosis (LAM) (EXIST-2)

Lymphangioleiomyomatosis (LAM) | Tuberous Sclerosis Complex (TSC)

United States, United Kingdom, Germany, Italy, Russian Federation, Netherlands, Japan, Canada, Poland, France, Spain
Laboratorio Elea Phoenix S.A.
Ministerio de Ciencia e Innovación, Spain

Completed

Use of Racotumomab in Patients With Pediatric Tumors Expressing N-glycolylated Gangliosides

Glioma | Neuroblastoma | Retinoblastoma | Wilm's Tumor | Ewing's Sarcoma

Argentina
Masonic Cancer Center, University of Minnesota

Completed

Stem Cell Transplant for Inborn Errors of Metabolism

Niemann-Pick Disease | Wolman Disease | Adrenoleukodystrophy | Batten Disease | Metachromatic Leukodystrophy | GM1 Gangliosidosis | Fucosidosis | Globoid Cell Leukodystrophy | Gaucher's Disease | Tay Sachs Disease | Sandhoff Disease

United States
Joanne Kurtzberg, MD
The Marcus Foundation

Recruiting

UCB Transplant of Inherited Metabolic Diseases With Administration of Intrathecal UCB Derived Oligodendrocyte-Like Cells (DUOC-01)

Mucopolysaccharidosis II | Brain Diseases, Metabolic, Inborn | Adrenoleukodystrophy | Batten Disease | Leukodystrophy, Metachromatic | Leukodystrophy, Globoid Cell | Alpha-Mannosidosis | Tay-Sachs Disease | Pelizaeus-Merzbacher Disease | Sandhoff Disease | Neimann Pick Disease | Sanfilippo Mucopolysaccharidoses

United States
University of Pennsylvania

Completed

Journey of Patients With Vasculitis From First Symptom to Diagnosis

Vasculitis | Giant Cell Arteritis | Microscopic Polyangiitis | Polyarteritis Nodosa | Systemic Vasculitis | Granulomatosis With Polyangiitis | Takayasu Arteritis | Cryoglobulinemic Vasculitis | Behcet's Disease | CNS Vasculitis | Temporal Arteritis | IgA Vasculitis | Urticarial Vasculitis | Wegener Granulomatosis | Eosinophilic... and other conditions

United States
University of Pennsylvania
University of South Florida; Duke University

Recruiting

Vasculitis Pregnancy Registry (V-PREG)

Vasculitis | Wegener's Granulomatosis | Systemic Vasculitis | Eosinophilic Granulomatosis With Polyangiitis (EGPA) | Churg-Strauss Syndrome (CSS) | Cryoglobulinemic Vasculitis | Behcet's Disease | CNS Vasculitis | IgA Vasculitis | Granulomatosis With Polyangiitis (GPA) | Microscopic Polyangiitis (MPA) | Polyarteritis... and other conditions

United States
Volastra Therapeutics, Inc.

Recruiting

A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer

Gastric Adenocarcinoma | Uterine Carcinosarcoma | Triple Negative Breast Cancer | Advanced Solid Tumor | Head and Neck Squamous Cell Carcinoma | Esophageal Adenocarcinoma | Esophageal Squamous Cell Carcinoma | Transitional Cell Carcinoma of Bladder | Colorectal Adenocarcinoma | Gastroesophageal Junction... and other conditions

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Energy Balance Interventions in Increasing Physical Activity in Breast Cancer Gene Positive Patients, Lynch Syndrome-Positive Patients, CLL Survivors or High-Risk Family Members

Fatigue | Overweight | Lynch Syndrome | Chronic Lymphocytic Leukemia | BRCA1 Gene Mutation | BRCA2 Gene Mutation | Breast Carcinoma | Cancer Survivor | Ovarian Carcinoma | Health Status Unknown | Body Mass Index 25 or Greater

United States
Memorial Sloan Kettering Cancer Center

Recruiting

A Study of Selinexor in People With Wilms Tumors and Other Solid Tumors

Solid Tumor | Rhabdoid Tumor | Wilms Tumor | Nephroblastoma | Malignant Peripheral Nerve Sheath Tumors | MPNST | XPO1 Gene Mutation

United States
Fundación Española de Hematología y Hemoterapía

Recruiting

PREDIGA 2: Spanish Acronym of "Educational and Diagnostic Project for Gaucher and ASMD" (PREDIGA-2)

Niemann-Pick Diseases | Gaucher Disease | Splenomegaly | Acid SphingoMyelinase Deficiency | ASMD

Spain
Memorial Sloan Kettering Cancer Center

Recruiting

An Intervention to Increase Genetic Testing in Families Who May Share a Gene Mutation Related to Cancer Risk

BRCA1 Mutation | BRCA2 Mutation | APC Gene Mutation | MLH1 Gene Mutation | RAD51C Gene Mutation | RAD51D Gene Mutation | BRIP1 Gene Mutation | PALB2 Gene Mutation | PTEN Gene Mutation | ATM Gene Mutation | CHEK2 Gene Mutation | BARD1 Gene Mutation | MSH2 Gene Mutation | MSH6 Gene Mutation | PMS2 Gene Mutation | POLD1 Gene... and other conditions

United States
National Cancer Institute (NCI)
Childrens Oncology Group (COG); LLS PedAL LLC

Recruiting

Highest Dose of Uproleselan in Combination With Fludarabine and Cytarabine for Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Mixed Phenotype Acute Leukemia Relapsed or Refractory and That Expresses E-selectin Ligand on the Cell Membrane

Down Syndrome | Recurrent Acute Myeloid Leukemia | Recurrent Myelodysplastic Syndrome | Refractory Acute Myeloid Leukemia | Refractory Myelodysplastic Syndrome | Recurrent Mixed Phenotype Acute Leukemia | Refractory Mixed Phenotype Acute Leukemia | Acute Myeloid Leukemia Post Cytotoxic Therapy | Myelodysplastic...

United States
Shanghai Jiao Tong University School of Medicine

Recruiting

China Adrenal Disease Registry (CASE)

Congenital Adrenal Hyperplasia | Cushing Syndrome | Pheochromocytoma | Adrenal Incidentaloma | Adrenal Adenoma | Adrenal Carcinoma | Aldosteronism | Hypoadrenalism

China
Children's National Research Institute

Recruiting

A Pilot Study of Thermodox and MR-HIFU for Treatment of Relapsed Solid Tumors

Soft Tissue Sarcoma | Ewing Sarcoma | Bone Metastases | Solid Tumors | Rhabdomyosarcoma | Wilms Tumor | Germ Cell Tumor | Hepatic Tumor | Malignant Epithelial Neoplasm

United States
Radboud University Medical Center

Recruiting

Turner Syndrome Minipuberty Study (Minipuberty)

Ovarian Diseases | Sex Chromosome Disorders | Infertility, Female | Turner Syndrome | Gonadal Dysgenesis | Premature Ovarian Failure | Premature Menopause

Netherlands, Germany, Poland, Sweden, Denmark
Beth Israel Deaconess Medical Center

Recruiting

Gait Analysis in Neurological Disease

Parkinson's Disease | Parkinsonian Disorders | Multiple System Atrophy | Corticobasal Degeneration | Progressive Supranuclear Palsy | Huntington Disease | Atypical Parkinson Disease | Gait, Frontal

United States
Sanguine Biosciences

Completed

A Biospecimen and Clinical Data Study on Patients for Drug & Biomarker Discovery

Multiple Sclerosis | Parkinson's Disease | Amyotrophic Lateral Sclerosis (ALS) | Alzheimer's Disease | Huntington's Disease

United States
Azienda Socio Sanitaria Territoriale degli Spedali...

Completed

Transcranial Alternating Current Stimulation (tACS) in Patients With Ataxia (SCAtACS)

Ataxia | Multiple System Atrophy | Spinocerebellar Ataxias | Ataxia With Oculomotor Apraxia | CANVAS

Italy
University of Massachusetts, Worcester

Enrolling by invitation

Genetic Study of Familial and Sporadic ALS/Motor Neuron Disease, Miyoshi Myopathy and Other Neuromuscular Disorders

Motor Neuron Disease | Amyotrophic Lateral Sclerosis | Muscular Dystrophy | Frontotemporal Dementia | Miyoshi Myopathy | Amyotrophic Lateral Sclerosis, Sporadic | PLS | Lou Gehrigs Disease | Familial Disease | Amyotrophic Lateral Sclerosis With Dementia

United States
Visionary Intelligence Ltd.
Peking University First Hospital; Beijing Municipal Science & Technology Commission

Completed

Computer Aided Diagnosis of Multiple Eye Fundus Diseases From Color Fundus Photograph

Diabetic Retinopathy | Retinal Vein Occlusion | Retinitis Pigmentosa | Optic Atrophy | Retinal Detachment | Epiretinal Membrane | Macular Holes | Central Serous Chorioretinopathy | Retinal Artery Occlusion | Suspect Glaucoma | Pathologic Myopia | Nonexudative Age-related Macular Degeneration | Exudative Age Related...

China
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Terminated

68Ga-DOTA-TOC PET/CT in Imaging Participants With Neuroendocrine Tumors

Meningioma | Neuroendocrine Neoplasm | Multiple Endocrine Neoplasia Type 1 | Von Hippel-Lindau Syndrome | Metastatic Well Differentiated Neuroendocrine Neoplasm | Somatostatin Positive Neoplastic Cells Present

United States
Altoosi University College
Babylon University

Unknown

Using NPT to Evaluate Providing PPC as ELNEC-PPC WBT for Nurses (ELNEC-PPC)

Cerebral Palsy | Cancer | HIV/AIDS | Muscular Dystrophy | Cystic Fibrosis | Cardiac Anomaly | Batten's Disease

Iraq
Eunice Kennedy Shriver National Institute of Child...

Completed

Characterization of WAGR Syndrome and Other Chromosome 11 Gene Deletions

Urogenital Abnormalities | Mental Retardation | Wilm's Tumor | WAGR Syndrome | Aniridia

United States
Massachusetts Eye and Ear Infirmary

No longer available

Compassionate Use Arm - ABI541 ABI for 10 NF2 Patients

Neurofibromatosis Type 2 | Severe Profound Sensorineural Hearing Loss

United States
Weill Medical College of Cornell University
University of California, Los Angeles; University of Wisconsin, Milwaukee

Completed

Psychosocial Intervention for Young Children With Chronic Tics (CBIT JR)

Tourette's Syndrome | Tourette's Disorder | Tourette Disorder | Gilles de la Tourette Syndrome | Tourette's Disease | Tourette Disease | Tic Disorder, Combined Vocal and Multiple Motor | Multiple Motor and Vocal Tic Disorder, Combined | Gilles de La Tourette's Disease | Gilles De La Tourette's Syndrome | Combined... and other conditions
Washington University School of Medicine
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Completed

Tracking Neurodegeneration in Early Wolfram Syndrome (TRACK)

Diabetes Mellitus | Type 1 Diabetes | Diabetes Insipidus | Wolfram Syndrome

United States
Synspira, Inc.

Terminated

A Study of the Safety and Tolerability of Inhaled SNSP113 in Healthy Subjects and Subjects With Stable Cystic Fibrosis

Lung Diseases | Cystic Fibrosis | Pulmonary Disease | Antibiotic Resistant Infection | Respiratory Tract Disease | Cystic Fibrosis Pulmonary Exacerbation | Lung Inflammation | Burkholderia Infections | Lung Infection | Multi-antibiotic Resistance | Pulmonary Inflammation | Lung Infection Pseudomonal | Cystic Fibrosis... and other conditions

United Kingdom
National Cancer Institute (NCI)

Withdrawn

RO4929097 in Children With Relapsed/Refractory Solid or CNS Tumors, Lymphoma, or T-Cell Leukemia

Sarcoma | Lymphoma | Brain Neoplasms | Osteosarcoma | Wilm's Tumor

United States
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Gene Mutation in Samples From Young Patients With Pleuropulmonary Blastoma Syndrome at Risk for Developing Cancer

Sarcoma | Kidney Cancer | Brain and Central Nervous System Tumors | Neuroblastoma | Liver Cancer | Pleuropulmonary Blastoma | Hereditary Wilms Tumor

Clinical Trials on Genetic High Risk for Schizophrenia

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Medical Conditions

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CROs by country

CROs in Vietnam

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