Clinical Trials on Heart Failure at NYHA Stage III or IV

Total 791 results

University Medical Centre Ljubljana

Active, not recruiting

Conduction System Pacing Versus Biventricular Pacing for Cardiac resYNChronization (CSP-SYNC)

Heart Failure | Left Bundle-Branch Block | Cardiac Remodeling, Ventricular | Dilated Cardiomyopathy With Conduction Defect | Resynchronization Therapy

Slovenia
BioMarin Pharmaceutical

Recruiting

Safety, Tolerability, and Efficacy Study of Valoctocogene Roxaparvovec in Hemophilia A With Active or Prior Inhibitors (GENEr8-INH)

Hemophilia A With Inhibitor | Hemophilia A With Anti Factor VIII

United States, United Kingdom, Taiwan, Israel, Korea, Republic of, South Africa, Brazil, Italy, Germany
PedNet Haemophilia Research Foundation
Lund University Hospital

Recruiting

The European Paediatric Network for Haemophilia Management ( PedNet Registry) (PedNet)

Factor IX Deficiency | Factor VIII Deficiency

Norway, Austria, Belgium, Canada, Czechia, Denmark, Finland, France, Germany, Greece, Ireland, Israel, Italy, Netherlands, Portugal, Spain, Sweden, Switzerland, United Kingdom
Children's Mercy Hospital Kansas City

Terminated

A Study Comparing Factor Level and Inhibitor Titer Testing Results Drawn From Central Venous Lines and Venipuncture (CVL#2)

Hemophilia A | Hemophilia B | Hemophilia | Factor IX Deficiency | Factor VIII Deficiency

United States
Universitätsmedizin Mannheim

Recruiting

Metabolomics and Microbiomics in Cardiovascular Diseases (MEMORIA)

Sepsis | Cardiomyopathies | Dilated Cardiomyopathy | Ischemic Cardiomyopathy | NSTEMI - Non-ST Segment Elevation MI | Acute Heart Failure | Myocardial Infarction, Acute | STEMI - ST Elevation Myocardial Infarction

Germany
Sonavex, Inc.

Recruiting

Maturation of Arteriovenous Fistula With Automated Sonography Assessments Trial (MAFASA)

Diabetes | End Stage Renal Disease

United States
National Cancer Institute (NCI)

Completed

Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer

Stage I Multiple Myeloma | Stage II Multiple Myeloma | Stage III Multiple Myeloma | Recurrent Adult Acute Myeloid Leukemia | Recurrent Adult Burkitt Lymphoma | Recurrent Adult Diffuse Large Cell Lymphoma | Recurrent Adult Diffuse Mixed Cell Lymphoma | Recurrent Adult Immunoblastic Large Cell Lymphoma and other conditions

United States
NewAmsterdam Pharma

Recruiting

Study of Obicetrapib & Ezetimibe Fixed Dose Combination on Top of Maximum Tolerated Lipid-Modifying Therapies (TANDEM)

Dyslipidemias | Hypercholesterolemia | Familial Hypercholesterolemia | High Cholesterol | ASCVD

United States
Seattle Children's Hospital
Actelion

Withdrawn

Inhaled Iloprost as an Adjunct to Inhaled Nitric Oxide in Pediatric Critical Care Patients

Pulmonary Hypertension | Acute Respiratory Distress Syndrome | Congenital Heart Defects | Neonatal Hypoxic Respiratory Failure | Persistent Pulmonary Hypertension of Newborn
Assiut University

Active, not recruiting

Familial Hypercolerstremia as Risk Factor in Stemi Patient Who Underwent Ppci

Familial Hypercholesterolemia

Egypt
Bark Technology LLP

Recruiting

Evaluation of the Effectiveness and Safety of Vibro-acoustic Pulmonary Therapy (VAPT) in Complex Therapy for Acute Respiratory Failure of Mixed Type I-II Stages in Comparison With Percussion Massage in Cardiac Surgical Patients in the Early Postoperative Period

Cardiac Surgical Patients (CABG,Mammary Coronary Bypass Surgery,Plastic and Replacement of Valves, Atrial Septal Defect,Ventricular Septal Defect)

Kazakhstan
Pardis Specialized Wellness Institute

Completed

Prevalence of Postural Abnormalities in Dialysis Patients

End Stage Renal Disease | Hemodialysis Complication | Peritoneal Dialysis Complication

Iran, Islamic Republic of
Medifil AE
International Renal Research Institute Vicenza

Completed

Maximizing Native Arteriovenous Fistulae Rates.

Hemodialysis | Kidney Failure | Arteriovenous Shunt
University of California, San Francisco

Recruiting

Registry of Patients Diagnosed With Lysosomal Storage Diseases (LSD Registry)

Mucopolysaccharidosis I | Mucopolysaccharidosis II | Mucopolysaccharidosis VI | Wolman Disease | Pompe Disease Infantile-Onset | Mucopolysaccharidosis IV A | Mucopolysaccharidosis VII | Neuronopathic Gaucher Disease

United States
Hoffmann-La Roche

Completed

An Observational Study to Evaluate Physical Activity, Bleeding Incidence and Health Related Quality of Life, in Participants With Haemophilia A Without Inhibitors Receiving Standard of Care Treatment (POWER)

Haemophilia A | Moderate Hereditary Factor VIII Deficiency Disease Without Inhibitor | Severe Hereditary Factor VIII Deficiency Disease Without Inhibitor

Italy
Charite University, Berlin, Germany
AstraZeneca

Not yet recruiting

Screen CardRen - A Cross-sectional Observational Cohort Study

Heart Failure | Chronic Kidney Diseases
PhaseBio Pharmaceuticals Inc.

Terminated

Pemziviptadil (PB1046), a Long-acting, Sustained Release Human VIP Analogue, Intended to Provide Clinical Improvement to Hospitalized COVID-19 Patients at High Risk for Rapid Clinical Deterioration and Acute Respiratory Distress Syndrome (ARDS). (VANGARD)

Pneumonia | Respiratory Failure | Respiratory Insufficiency | COVID 19 | Acute Respiratory Distress Syndrome | SARS-CoV-2 | Coronavirus | Cytokine Storm | Pulmonary Edema | Cardiac Event | Respiratory Complication | Cardiac Dysfunction | Hypoxemic Respiratory Failure | Hypoxic Respiratory Failure | Cardiac Failure | Cardiac... and other conditions

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Evaluation of Patients With Known or Suspected Heart Disease

Heart Failure | Coronary Disease | Pulmonary Hypertension | Peripheral Artery Disease | Dilated Cardiomyopathy | Renal Artery Stenosis | Diabetes and Heart Failure

United States
Tomsk National Research Medical Center of the Russian...

Not yet recruiting

Left Bundle Branch Pacing on Outcomes and Ventricular Remodeling in Biventricular CRT Nonresponders (RESCUE)

Heart Failure | Left Bundle-Branch Block | Ischemic Cardiomyopathy | Left Ventricular Dysfunction | Non-ischemic Dilated Cardiomyopathy | Left Ventricle Remodeling

Russian Federation
Federico II University

Completed

Growth Hormone Deficiency in Chronic Heart Failure: A Preliminary Trial

Heart Failure | Ischemic Heart Disease | Growth Hormone Deficiency
Albert Einstein College of Medicine
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Enrolling by invitation

ScreenPlus: A Comprehensive, Flexible, Multi-disorder Newborn Screening Program (ScreenPlus)

Mucopolysaccharidosis II | Fabry Disease | Niemann-Pick Disease, Type C | Mucopolysaccharidosis VI | Lysosomal Acid Lipase Deficiency | Metachromatic Leukodystrophy | Gaucher Disease | Cerebrotendinous Xanthomatosis | Mucopolysaccharidosis IV A | GM1 Gangliosidosis | Mucopolysaccharidosis VII | Acid Sphingomyelinase... and other conditions

United States
Laval University
Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie... and other collaborators

Active, not recruiting

Diet Quality and Coronary Artery Calcification in Adults With Heterozygous Familial Hypercholesterolemia (FH-CAC)

Diet Habit | Hypercholesterolemia, Familial | Calcification; Heart

Canada
Fatebenefratelli Hospital
Federico II University; Federal University of Rio Grande do Sul; Royal Brompton... and other collaborators

Recruiting

Stress Echo 2020 - The International Stress Echo Study (SE2020)

Coronary Artery Disease | Heart Failure | Aortic Valve Disease | Pulmonary Arterial Hypertension | Tetralogy of Fallot | Hypertrophic Cardiomyopathy | Athletes Heart

Italy
Pfizer

Completed

Post-Marketing Surveillance To Observe Safety And Efficacy Of Xyntha Solofuse Prefilled Syringe

Factor VIII Deficiency, Congenital | Hemophilia A, Congenital | Factor 8 Deficiency, Congenital | Autosomal Hemophilia A | Classic Hemophilia
National Cancer Institute (NCI)

Active, not recruiting

Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery

Leiomyosarcoma | Fibrosarcoma | Liposarcoma | Mesenchymal Chondrosarcoma | Stage III Soft Tissue Sarcoma AJCC v7 | Stage IV Soft Tissue Sarcoma AJCC v7 | Malignant Peripheral Nerve Sheath Tumor | PEComa | Synovial Sarcoma | Epithelioid Sarcoma | Alveolar Soft Part Sarcoma | Undifferentiated High Grade Pleomorphic... and other conditions

United States, Canada, Puerto Rico
Barts & The London NHS Trust
Queen Mary University of London

Recruiting

Recovery From ICUAW Following Severe Respiratory and Cardiac Failure (CLEVERER)

Respiratory Failure | Acute Respiratory Distress Syndrome | Critical Illness Myopathy | Intensive Care Unit Syndrome | Cardiac Failure | Intensive Care (ICU) Myopathy | Intensive Care Neuropathy

United Kingdom
Georgetown University

Completed

Randomized Study of Folic Acid Therapy for Hyperhomocysteinemia in Patients With End Stage Renal Disease Receiving Hemodialysis

End Stage Renal Disease | Hyperhomocysteinemia

United States
Heidi Moretti, MS, RD
University of Arkansas; Saint Patrick Hospital

Completed

Biotin Deficiency and Restless Legs Syndrome

Restless Legs Syndrome | End Stage Renal Disease
Bicetre Hospital

Completed

Hemodynamic Characteristics of Patients With SARS-CoV-2 (PiCCOVID)

COVID-19 | Shock | Acute Respiratory Distress Syndrome | SARS-CoV-2 | Fluid Overload | Coronavirus | Left Ventricular Dysfunction | Acute Circulatory Failure

France
King's College Hospital NHS Trust
King's College London

Completed

SELF-BREATHE RCT for Chronic Breathlessness

Liver Failure | Cancer | Asthma | Renal Failure | Cystic Fibrosis | Chronic Heart Failure | Sickle Cell Disease | Interstitial Lung Disease | COPD | Dyspnea | Post COVID-19 | Bronchiectasis Adult

United Kingdom
Karolinska Institutet

Enrolling by invitation

Evaluation of a Digiphysical Screening Method to Identify and Diagnose Familial Hypercholesterolemia (DigiLipids)

Hypercholesterolemia | Familial Hypercholesterolemia

Sweden
Organon and Co

Completed

Vytorin Reexamination Study (0653A-174)

Primary Hypercholesterolemia and Homozygous Familial Hypercholesterolemia (HoFH)
REGENXBIO Inc.

Completed

Identifying and Genotyping Homozygous Familial Hypercholesterolemia (HoFH) Patients

Homozygous Familial Hypercholesterolemia (HoFH)

United States
National Taiwan University Hospital

Unknown

A Registration Study for Familial Hypercholesterolemia in Taiwan

Familial Hypercholesterolemia

Taiwan
REGENXBIO Inc.

Active, not recruiting

A Long-term Follow-up Study to Evaluate the Safety and Efficacy of RGX-501

Homozygous Familial Hypercholesterolemia (HoFH)

United States, Canada, Netherlands
Karo Bio AB

Terminated

Efficacy and Safety Study of Eprotirome in HeFH Patients Who Are on Optimal Standard of Care (AKKA)

Heterozygous Familial Hypercholesterolaemia
Jiangsu Gensciences lnc.

Completed

A Phase I of SS109 in Hemophilia A or and B With Inhibitors

Factor VII Deficiency | Hemophilia A With Inhibitor | Hemophilia B With Inhibitor

China
Novo Nordisk A/S

Completed

Treatment of Congenital Factor VII Deficiency (F7CONDEF)

Congenital Bleeding Disorder | Congenital FVII Deficiency

Slovakia, Israel, Spain, India, Iran, Islamic Republic of, Pakistan, Turkey, Germany, Serbia, Italy, Greece, Thailand, France, United States, Hong Kong, Venezuela
Federico II University

Completed

Growth Hormone Deficiency in Chronic Heart Failure: an Observational Study

Heart Failure | Ischemic Heart Disease | Growth Hormone Deficiency | Cardiomyopathy

Italy
Spark Therapeutics

Completed

Lead-in Study to Collect Prospective Efficacy and Safety Data of Current FVIII Prophylaxis Replacement Therapy in Adult Hemophilia A Participants

Hematologic Diseases | Hemophilia A | Blood Coagulation Disorders, Inherited | Coagulation Protein Disorders | Hemorrhagic Disorders | Genetic Diseases, Inborn | Genetic Diseases, X-Linked | Blood Coagulation Disorder | Factor VIII Deficiency

United States, Australia, Thailand, Canada
Novo Nordisk A/S

Completed

Safety of Monthly Recombinant Factor XIII Replacement Therapy in Subjects With Congenital Factor XIII Deficiency: An Extension to Trial F13CD-1725 (mentor™2)

Congenital Bleeding Disorder | Congenital FXIII Deficiency

France, United States, Israel, Spain, Switzerland, Germany, Canada, Japan, United Kingdom, Italy, Finland, Austria
The Hospital for Sick Children
Canadian Hemophilia Society

Completed

An Institutional Pilot Study to Investigate Physical Activity Patterns in Boys With Hemophilia (HEPS)

Hemophilia A | Hemophilia B | Factor IX Deficiency | Factor VIII Deficiency

Canada
Tomsk National Research Medical Center of the Russian...

Recruiting

Conventional Biventricular Versus Left Bundle Branch Pacing on Outcomes in Heart Failure Patients (RECOVER-HF)

Heart Failure | Left Bundle-Branch Block | Ischemic Cardiomyopathy | Left Ventricular Dysfunction | Left Ventricular Dyssynchrony | Non-ischemic Dilated Cardiomyopathy | Left Ventricle Remodeling

Russian Federation
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Hyperapo B and Coronary Heart Disease

Heart Diseases | Cardiovascular Diseases | Coronary Disease | Obesity | Diabetes Mellitus | Hypercholesterolemia, Familial
National Heart, Lung, and Blood Institute (NHLBI)

Completed

NHLBI Type II Coronary Intervention Study

Myocardial Infarction | Myocardial Ischemia | Heart Diseases | Cardiovascular Diseases | Coronary Disease | Hypercholesterolemia, Familial
Hospices Civils de Lyon

Unknown

Study of the Prevalence of Fabry Disease in French Dialysis Patients (FABRYDIAL)

End Stage Renal Disease | Fabry Disease | Renal Dialysis

France
E. Peden, MD
The Methodist Hospital Research Institute

Recruiting

Hemodialysis in the Elderly (70yrs & Older) (ELDERLY)

Chronic Kidney Disease | Kidney Failure | Kidney Disease

United States
Federico II University

Recruiting

Subclinical Atherosclerosis in Patients With Familial Hypercholesterolemia Treated With Evolocumab®

Hypercholesterolemia, Familial

Italy
Ege University
Turkish Society of Cardiology

Completed

Familial Hypercholesterolemia in Turkey (A-HIT2) (A-HIT2)

Atherosclerosis | Familial Hypercholesterolemia

Turkey
University of Nebraska

Completed

Arteriovenous Fistula Tissue Bank for Pre- and Post-Fistula Placement Specimens

Kidney Failure, Chronic

United States

Clinical Trials on Heart Failure at NYHA Stage III or IV

Sponsors and Collaborators

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Drug Interventions

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CROs in Mali

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